Chemical Process Systems (CPS)
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The Chemical Process Systems (CPS) program by the U.S. National Science Foundation focuses on advancing fundamental research in chemical and biochemical processes to enhance efficiency, sustainability, and resilience. It supports innovation across a wide range of areas including reaction engineering, molecular thermodynamics, reactor design, catalysis, electrochemical systems, separations, and overall process design. The program encourages bridging molecular-level insights with large-scale process and plant operations and promotes exploration of new reactor configurations such as microreactors and catalytic reactors. It also emphasizes the development of catalysis and electrochemical systems aimed at improving energy production, waste reduction, polymer processing, fuel synthesis, and nuclear fuel cycle support. CPS also targets scalable and efficient chemical and biological separations, focusing on designing membranes, sorbents, and interfaces for applications in gas separation, critical mineral recovery, bioprocessing, and purification technologies. Incorporating advanced tools like artificial intelligence, machine learning, and uncertainty quantification into process design and optimization is another critical aspect of the program. Additionally, the program supports research in emerging areas such as quantum information science and engineering, which may accelerate material discovery and enhance process modeling. To accelerate innovation, the NSF collaborates with federal agencies, industry, and international partners. The solicitation for this program was posted on April 24, 2026, and further information and partnership opportunities are available through NSF channels.
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Research supported by the CPS program covers the full breadth of chemical and biochemical process innovation. It spans reaction engineering and molecular thermodynamics; reactor design; catalysis; electrochemical systems; separations; and process design. The program encourages proposals that connect the molecular scale to process and plant scales.
The CPS program explores active-site structure and function, reaction mechanisms, in situ and operando characterization, durability, and device-level integration. Microreactors, membrane and catalytic reactors, atmospheric plasmas, and other novel configurations are of interest.
The program supports research in catalysis and electrochemical systems to produce, use, and store energy, to reduce waste, to process polymers, and to synthesize fuels and chemicals. This includes process and materials innovation to support the nuclear fuel cycle.
The CPS program also targets chemical and biological separations that are efficient and scalable. Research includes the design of membranes, sorbents, and specialized interfaces. Advances can be used in gas separations, the recovery of critical minerals, bioprocessing, and protein and water purification.
The program supports research in process design and optimization that uses tools such as artificial intelligence, machine learning, and uncertainty quantification. CPS research also explores quantum information science and engineering; quantum simulation and sensing, for example, may accelerate the discovery of materials and improve process models.
Partnerships: To speed discovery and innovation, NSF partners with federal agencies, industry, international groups, and others. Current opportunities are at NSF ENG Partnerships.