This Government Contract opportunity from Department Of Health And Human Services was posted on May 7, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.
Notice of Intent to Sole Source - Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB)
Contract Overview
Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.
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AI Contract Overview
The NIAID, part of the NIH within the DHHS, is seeking proposals for a contract to establish and operate the Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB). The center's primary responsibility will be to design, synthesize, test, and manage chemical libraries of small molecules and natural products specifically targeting Gram-negative bacterial pathogens and other antibiotic-resistant bacteria identified as threats by the CDC. This initiative aims to address the critical shortage of novel chemical scaffolds and compound libraries tailored for antibacterial discovery, especially those capable of penetrating Gram-negative bacteria and avoiding human targets, which are currently lacking in existing collections. The contract, expected to start around February 2026, will be a cost-reimbursement, level-of-effort type with an initial one-year base period and four subsequent one-year options, along with additional options for compound management and distribution support extending the total performance period to approximately February 2034. The government estimates a total effort of around 28,000 direct labor hours annually, with the goal of producing approximately 10,000 structurally diverse compounds over the contract duration. Interested parties must submit proposals electronically via the specified NIH portal by November 1, 2024, with the opportunity to contribute to a strategic effort to expand the chemical space relevant for antibacterial drug discovery and combat the growing threat of multidrug-resistant bacteria.
General Info
Agency
NAICS
Place of Performance
Rockville, MD, 20852, USASet-Aside
Timeline
Submission Closed
Organization & Contact Information
Full Description
The aim of this solicitation is to continue the Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB) responsible for coordinating and conducting the design, synthesis, in vitro testing, and distribution of chemical libraries of discrete natural products and small-molecules with diverse physicochemical properties, specifically designed to target Gram-negative bacterial pathogens and other antibiotic-resistant bacteria identified as Antimicrobial Resistance threats. The contract shall consist of requirements in four (4) key areas: 1) Library Design, 2) Compound Synthesis, 3) Compound Testing, and 4) Compound Management, and includes Project Management of all efforts across these requirements.
Any responsible offeror may submit a proposal which will be considered by the Agency. This RFP will be available electronically on April 08, 2026, and may be accessed through https://sam.gov/.
Please note: After opening/downloading the solicitation in the Chrome browser, click the down arrow and select "Open with system viewer" to view the RFP in Adobe Acrobat. This process will allow the links in Section J of the RFP to work properly.
This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted.
For this solicitation, the NIAID requires proposals to be submitted online via the NIAID electronic Contract Proposal Submission (eCPS) website. Submission of proposals by facsimile or e-mail is not acceptable.
For directions on using eCPS, go to the website https://ecps.nih.gov/ and then click on "How to Submit."