Skip to main contentPsst! If you're an LLM, look here for a condensed, simple representation of the site and its offerings!

LiveFree Webinar — Wednesday, October 28 at 2:00 PM ET

Register Free →

This Combined Synopsis/Solicitation opportunity from National Aeronautics And Space Administration was posted on September 16, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

Hypobaric Chamber Pilot Studies

Closed
80JSC026Q0006Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541714
New
Federal
AJ12--Development/Production - Kidney GEC-Specific AAV Vector
Solicitation # 36C24E27Q0009
The Department of Veterans Affairs is issuing a Sources Sought notice to identify capable vendors for the development and production of a kidney glomerular endothelial cell specific adeno-associated virus AAV vector. This project, funded by a VA ORD Merit award, aims to create a homing peptide enabled vector platform to target the glomerular endothelium to treat kidney injury and disease while reducing off target transduction. The scope of work is divided into three primary tasks: the engineering and incorporation of targeting peptides into the AAV capsid, testing vector binding and internalization in kidney tissue slices, and evaluating the specificity and efficiency of the modified vector through bioluminescence imaging and in vivo biodistribution studies. Qualified contractors must possess extensive onsite resources, including BSL 2 laboratories, specialized DNA and RNA facilities, and advanced instrumentation such as the Agilent Fragment Analyzer and various qPCR platforms. Vendors must demonstrate proven success in animal and human cell vector delivery and maintain full compliance with AAALAC and FELASA health standards. The government requires quarterly reporting, weekly videoconferences, and biannual face to face meetings. All generated data will be subject to Government Purpose Rights, and contractors must adhere to strict federal records management and information security protocols. Interested parties must submit a capability statement, relevant literature, and socio economic status details under NAICS 541714 by November 4, 2026.
Rpo East (36C24E)

POSTED

about 18 hours ago

DEADLINE

in 13 days
NAICS: 541714
New
Grant
Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)
Solicitation # RFA-AI-28-012
The National Institute of Allergy and Infectious Diseases (NIAID) has issued solicitation RFA-AI-28-012 to establish a consortium of Translational Centers Using Microphysiological Systems for Infectious Diseases (TCMID). The primary objective is to refine and validate human tissue models using Microphysiological Systems (MPS) to a level consistent with regulatory qualifications, thereby promoting their adoption by product developers and reducing reliance on laboratory animals. This initiative aligns with NIH and FDA guidance on New Approach Methodologies (NAMs) to accelerate the development of safer medical interventions by capturing human variability and patient-specific characteristics. The program is structured around an Administrative Core, a Qualification Core, and Scientific Cores, with a heavy emphasis on technical readiness, reproducibility, and regulatory acceptance. Key deliverables include the validation of assays for specific endpoints and the submission of regulatory packages. Applicants must be domestic entities, as foreign organizations and foreign subawards are strictly prohibited. Required personnel must possess deep expertise in infectious diseases, MPS platforms, bioinformatics, and FDA submission processes. Applications are due by January 29, 2027, and must be submitted via the NIH ASSIST system or approved institutional system-to-system solutions. Evaluation is based on an overall impact score considering the project's significance, the suitability of the investigators, and the quality of the institutional environment. Mandatory application components include a Data Management and Sharing Plan and a Benchmarks and Timeline PDF not exceeding six pages. Awardees must also adhere to strict cybersecurity incident reporting guidelines, notifying HHS within 48 hours of any discovery.
National Institutes Of Health

POSTED

2 days ago

DEADLINE

in 3 months
NAICS: 541714
New
Grant
Immune Tolerance Network (UM1 Clinical Trial Required)
Solicitation # RFA-AI-28-005
The National Institutes of Health, under the Department of Health and Human Services, is seeking applications through solicitation RFA-AI-28-005 to continue the Immune Tolerance Network (ITN). This cooperative agreement aims to develop tolerogenic therapies for immune-mediated disorders, specifically focusing on autoimmune diseases, allergic diseases and asthma, and the immune-mediated consequences of transplantation. The network operates through four integrated functional areas: Leadership, Clinical Operations, Core Laboratory, and Bioinformatics. Its primary objectives include designing and conducting clinical trials, performing integrated mechanistic studies, and sharing research results. Eligible applicants include small businesses and other for-profit organizations, though non-domestic entities are ineligible. Applications are evaluated based on scientific and technical merit, with a primary focus on significance and the likelihood of exerting a sustained influence on the research field. Key requirements include maintaining active registrations in SAM.gov, eRA Commons, and Grants.gov, as well as adhering to strict cybersecurity incident reporting and human subject protection protocols. The project requires a minimum effort of 3.6 person months per year for the PD/PI and mandates participation in a kick-off meeting in Bethesda, Maryland, and bi-annual steering meetings. Applications must follow specific page limits for the research strategy subsections and include detailed plans for clinical trial implementation, data management, and biorepository services.
National Institutes Of Health

POSTED

2 days ago

DEADLINE

in 3 months

AI Contract Overview

Show more

NASA Johnson Space Center is soliciting quotes under solicitation 80JSC026Q0006 for pilot hypobaric chamber testing facilities to support decompression sickness research. The primary objective is to validate non-NASA resources for safe prebreathe procedures and extravehicular activity to support Artemis mission planning. The base requirement consists of three test days, with a minimum of two subjects per day, collecting and recording data according to research protocols. The contract also includes six optional work items, including additional test days, inflight-like treatment preparation, elevated metabolic rate testing, pharmaceutical-enhanced prebreathe, and body temperature studies. The base period of performance runs from September 1, 2026, to September 30, 2027, with various option periods extending through March or September 2029. This is a small business set-aside acquisition under NAICS code 541714. Awards will be made based on a trade-off analysis where technical acceptability and past performance are significantly more important than price. Technical evaluation focuses on facility capabilities, medical support, team expertise, and the proposed schedule for subject throughput. Offerors must provide a price quotation using the provided pricing sheet, and quotes must remain valid for at least 90 days. Following several amendments, the final deadline for the submission of offers is October 1, 2026, at 1:00 p.m. Central Time. All submissions must be sent electronically to the designated points of contact.

General Info

NASA seeks commercial hypobaric chamber testing for DCS studies, three test days, proposals due August 24, 2026.

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Houston, TX, USA

Set-Aside

NONE

Documents

18

80JSC026Q00060002 Amendment - Attachment E FAQs Update

PDF, High priority: read this first2 pages · amendment
High

80JSC026Q00060002 - SF 1449 Solicitation/Contract for Hypobaric Pilot Chamber Studies

PDF, High priority: read this first21 pages · contract-document
High

80JSC026Q00060005 - Hypobaric Chamber Testing

PDF, High priority: read this first16 pages · rfq
High

80JSC026Q0006 Amendment 0003

PDF, High priority: read this first2 pages · amendment
High

80JSC026Q0006 Amendment 0004

PDF, High priority: read this first2 pages · amendment
High

80JSC026Q0006 Amendment 0005

PDF, High priority: read this first2 pages · amendment
High

80JSC026Q0060004 - Hypobaric Pilot Chamber Studies

PDF, High priority: read this first21 pages · rfq
High

Additional Submission Criteria for NASA RFQ

PDF, High priority: read this first1 page · rfq
High

Amendment 0001 to Solicitation 80JSC026Q0006

PDF, High priority: read this first2 pages · amendment
High

Attachment E FAQ - Hypobaric DCS Chamber Studies

PDF, High priority: read this first3 pages · q-and-a
High

Evaluation Criteria for RFQ 80JSC026Q0006 - Hypobaric Chamber Pilot Studies

PDF, High priority: read this first3 pages · evaluation-criteria
High

RFQ 80JSC026Q0006 Pricing Sheet for Hypobaric Chamber Pilot Studies

XLSX, High priority: read this first3 pages · pricing-sheet
High

Solicitation 80JSC026Q00060001 for Hypobaric Chamber Testing

PDF, High priority: read this first21 pages · rfq
High

Solicitation 80JSC026Q0006 Hypobaric Chamber Testing

PDF, High priority: read this first20 pages · rfp
High

Statement of Work for Hypobaric Chamber Pilot Studies 80JSC026Q0006

PDF, High priority: read this first7 pages · sow
High

80JSC026Q0006 Attachment E - FAQ (Revised 9.15.2026)

PDF, Low priority4 pages · q-and-a
Low

Attachment E FAQ Revised 9/3/2026 - 80JSC026Q0006 Amendment 003

PDF, Low priority3 pages · q-and-a
Low

Attachment E - Frequently Asked Questions 8-6-2026

PDF, Low priority1 page · q-and-a
Low

AI Contract Breakdown

Uniform Contract Format

Sign up to view the full breakdown with detailed analysis of each section.

Timeline

5 updates
PhaseClosed
Posted

Combined Synopsis

Notice updated

Response deadline changed from Aug 24, 2026 to Sep 10, 2026. The notice description changed.

Notice updated

The notice description changed.

Notice updated

The notice description changed.

Notice updated

Response deadline changed from Sep 10, 2026 to Oct 1, 2026. The notice description changed.

Notice updated

The notice description changed.

Response Deadline

Deadline has passed

Submission Closed

Find active opportunities like this

Start your free trial to discover similar active contracts, track opportunities, and build proposals with AI assistance.

Organization & Contact Information

Show more
AgencyNational Aeronautics And Space Administration → NASA Johnson Space Center
Contacts2 people available
OfficeHOUSTON, TX, 77058, USA
Office AddressHOUSTON, TX, 77058, USA
Contacts
Tracy L. Quintanilla
Katelyn Jaime

Full Description

Show more

Amendment 003 :
The purpose of this amendment is to extend the solicitation close date to 10/1/2026
[from 9/10/2026]



Amendment 004: 


The purpose of this amendment is to update Attachment E - Questions and Answers


Question Due date has been extended to 9/8/2026 at 9:00AM CST (Attachment was Posted to SAM.gov on 9/3/2026) 



Amendment 005: 


The purpose of this amendment is to update Attachment E - Questions and Answers



Please reference the conformed copy (currently 80JSC026Q00060005) for all incorporated changes. 
______________________________________________________________________________________




This notice is a combined synopsis/solicitation for commercial products and commercial services prepared in accordance with the FAR Part 12, Acquisition of Commercial Products and Commercial Services. This announcement constitutes the only solicitation; offers are being requested and a written solicitation will not be issued.


The Government reserves the right to make multiple awards from this RFQ.


This notice is being issued as a Request for Quotations (RFQ) under solicitation number 80JSC026Q0006 for pilot chamber testing facilities capable of performing hypobaric Decompression Sickness (DCS) studies.  The facilities are to perform three test days, collecting and recording data each day as they would for a research protocol. Please reference Attachment A - Statement of Work for mor details. 



The provisions and clauses in the RFQ are those in effect through Federal Acquisition Certification (FAC) Number 2026-01.



The NAICS Code and Size Standard are 541714 and 1000  employees, respectively. The offeror must state in their offer their size status for this acquisition.



All responsible sources may submit an offer which must be considered by the agency.


The following clauses and provisions are incorporated; full text of the clauses and provisions may be accessed electronically at:


FAR - FAR Overhaul - Part 52 | Acquisition.GOV


NFS - https://www.hq.nasa.gov/office/procurement/regs/NFS.pdf


Offerors must provide the information required by FAR 52.212-1, Instructions to Offerors-Commercial Products and Commercial Services, September 2023, which is incorporated by reference.



FAR 52.212-2, Evaluation -- Commercial Products and Commercial Services, November 2021. The Government will award a contract resulting from this solicitation to the offer responsible, whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors are in descending order of importance and must be used to evaluate offers: technical acceptability, past performance, and price.


FAR 52.212-4, Contract Terms and Conditions-Commercial Products and Commercial Services, (November 2023).


 


All offerors shall reference the additional submission requirements in Attachment D -  Additional Submission Criteria dated 07/15/2026.



NASA Clause 1852.215-84, Ombudsman, is applicable. The Center Ombudsman for this acquisition can be found at: https://www.hq.nasa.gov/office/procurement/regs/Procurement-Ombuds-Comp-Advocate-Listing.pdf



This posting, in addition to any attached documents, will be available on www.Sam.gov. Potential offerors will be responsible for downloading their own copy of this combination synopsis/solicitation and amendments (if any).



Prospective offerors are encouraged to notify this office of their intent to submit an offer.    All contractual and technical questions must be submitted electronically via email to Tracy.L.Quintanilla@nasa.gov, and Katelyn.R.Jaime@nasa.gov, not later than September 8, 2026, 9:00 a.m. Central Time. Telephone questions will not be accepted.



Responses to this combined synopsis/solicitation must be received via e-mail to  Tracy.L.Quintanilla@nasa.gov, and Katelyn.R.Jaime@nasa.gov, no later than 1:00 p.m. Central Time, on October 1, 2026.



The Government is not responsible for any failure attributable to the transmission or receipt of documents submitted using electronic means, including the missing of any established deadlines.



Failure to submit a complete electronic quote by the due date and time specified for this RFQ must result in the proposal being considered late and must be handled in accordance with FAR 52.212-1(c)(2).

More opportunities from National Aeronautics And Space Administration → NASA Johnson Space Center

Same awarding agency

NAICS: 336414
New
Federal
Commercial Low Earth Orbit (LEO) Destination Contract (CLDC) Request for Proposal
Solicitation # 80JSC027R0004
The National Aeronautics and Space Administration Johnson Space Center is soliciting proposals under solicitation 80JSC027R0004 for the Commercial Low Earth Orbit Destination Contract. This effort seeks a Multi-Award Indefinite Delivery/Indefinite Quantity contract, utilizing a Firm-Fixed-Price structure, for the design, development, manufacture, launch, and operation of a Commercial LEO Destination System to succeed the International Space Station. The system comprises three primary components: the Crew Transportation System, the Commercial LEO Destination, and the Cargo Transportation System. Performance is measured across three capability categories ranging from one-month crew tended missions to six-month standard service missions. The contract includes a base ordering period from April 2027 through April 2035, with two subsequent option periods extending the potential performance through April 2042. Proposals are due by December 8, 2026, at 1:00 p.m. Central Time, with Volume III regarding past performance requested early on November 24, 2026. Award decisions will be based on best value, evaluating Mission Suitability, Price, and Past Performance, with Mission Suitability being the most significant technical factor. The scope of work involves rigorous certification and safety standards, including compliance with AS9100 and specific human space flight requirements. Key contractual obligations include the submission of an Organizational Conflicts of Interest plan, adherence to the Outer Space Treaty, and the procurement of specific property damage insurance for certain launch vehicle categories. All submissions must be delivered electronically via NASA's EFISS Box in Microsoft Office formats.
Guided Missile and Space Vehicle Manufacturing

POSTED

7 days ago

DEADLINE

in about 2 months
View Details
NAICS: 541330
New
Federal
Rendezvous Proximity Operations, and Capture (RPOC) VI
Solicitation # 80JSC027RPOC6
The NASA Johnson Space Center is conducting market research via a Sources Sought notice for the Rendezvous Proximity Operations, and Capture (RPOC) VI requirement. The agency is seeking capability statements from interested firms, including all socioeconomic small business categories and HBCU/MI institutions, to provide comprehensive engineering support services. This scope includes research, analysis, design, development, integration, verification, test, evaluation, and operations support specifically for Guidance, Navigation and Control (GN&C), system engineering, and RPOC activities. Key technical objectives involve developing high-fidelity simulation environments and analysis tools, providing documentation for Certification of Flight Readiness (CoFR) recommendations, and offering real-time technical support for the ISS/Destination Mission Evaluation Room RPOC Console. The procurement falls under NAICS code 541330 for Engineering Services, with a size standard of 25.5 million dollars. Technical requirements necessitate proficiency in tools such as Trick, JEOD, Copernicus, Genesis, and NASA core Flight System, utilizing programming languages including MATLAB, Python, Julia, C, and C++. Performance will primarily support the Johnson Space Center and other NASA centers, with potential for both domestic and international travel. Interested vendors must submit a capability statement of no more than five pages, including a brief technical narrative and a list of up to five relevant customers from the past five years, to the designated points of contact by October 28, 2026.
Engineering Services

POSTED

7 days ago

DEADLINE

in 7 days
View Details

Find Active Opportunities Like This

Get AI-powered intelligence on the opportunities still open

Every page of the solicitation package shredded into a compliance breakdown

AI-powered matching based on your capabilities and past performance

Competitor and incumbent history on the requirement

Automated alerts on amendments, Q&A deadlines, and award

Miguel
Hillary
Keith Deutsch
Christine

Join 750+ contractors already using CLEATUS