Chemistry Research for the Division of Translational Toxicology (DTT)

The National Institute of Environmental Health Sciences (NIEHS), through its Division of Translational Toxicology (DTT), is seeking chemistry research support to advance the National Toxicology Program’s mission of understanding how environmental factors impact human health. This acquisition, identified by solicitation number 75N94026R00002, is a market research effort aimed at identifying qualified vendors capable of providing comprehensive chemistry services across eight functional areas: Logistics and Handling, Characterization, Formulation, Biosample Analysis, Special Studies, Animal Studies, Omics, and In Vitro Assays. The contractor will be responsible for end-to-end chemistry support, including handling hazardous materials, developing and validating analytical methods, conducting toxicokinetic and ADME studies, and ensuring compliance with FDA Good Laboratory Practices, DOT regulations for chemical transport, and NCI guidelines. Work is to be performed at the contractor’s facilities, coordinated closely with DTT in Bethesda, Maryland, where all data and reports must be submitted electronically through the DTT Program Management System in accordance with Section 508 accessibility standards. The anticipated contract structure includes a ten-year base period with an optional six-month extension, and the government expects to use a Cost Plus Fixed-Fee contract type. Evaluation of future proposals will prioritize technical performance, with Logistics and Handling carrying the highest weight at 30%, followed by key areas such as Biosample Method Development and Chemical Identity and Purity at a weight of five. Proposals must include detailed Quality Management Plans, Health and Safety Plans, and IT Security Plans, all of which must be approved prior to work commencement. Key personnel, including the Principal Investigator and Quality Assurance Officer, must be direct employees of the prime contractor, and subcontractors may not fulfill these roles. Facilities involved in animal work must hold AAALAC accreditation and maintain an active IACUC, while the prime contractor must hold DEA licensing for controlled substances. The solicitation requires respondents to submit a single 15-page Capability Statement via email by March 4, 2026, with the document limited to Word or PDF formats. While this posting is for market research and not a formal solicitation, it sets the stage for a future contract with no set-aside classification under NAICS code 541715, and the government will consider all business sizes in the selection process. Financial and administrative details, including payment methods and accounting codes, will be finalized in the subsequent Request for Proposal.