Single Source Competition for Continuation of Understanding and Targeting the Pathophysiology of Youth-Onset Type 2 Diabetes Clinical Centers (U01 Clinical Trial Not Allowed)

The DISCOVERY study is a multi-center longitudinal effort involving 19 clinical sites dedicated to identifying risk factors and biological mechanisms underlying the development of type 2 diabetes in youth during early puberty. The study is actively recruiting and following high-risk participants over time to understand the progression of the disease, with the Biostatistics Research Center serving as the central coordinating hub responsible for protocol execution, data management, quality control, statistical analysis, and seamless coordination across all participating sites. The center has built a comprehensive infrastructure to ensure data integrity and consistency throughout the prolonged follow-up period. This solicitation seeks to continue support for the existing clinical consortium to achieve its scientific goals, focusing on advancing knowledge of youth-onset type 2 diabetes pathophysiology. The funding opportunity is issued by the National Institutes of Health under the Department of Health and Human Services through a single-source competition, with no set-aside designation. The opportunity is managed by the Division of Diabetes, Endocrinology and Metabolic Diseases, and all correspondence should be directed to niddk_dem@nih.gov. The forecast was posted on August 4, 2026, and no clinical trial is permitted under this award.