Investigator-Focused Award (Parent R35)
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The National Institutes of Health is preparing to release a Parent R35 Investigator-Focused Award opportunity to support researchers at all career stages, including Early Stage Investigators, through a funding mechanism designed to sustain an entire program of research aligned with the mission of the awarding Institute or Center. Unlike traditional grants that fund specific projects with defined aims, the R35 provides broad, long-term support for an investigator’s scientific vision, enabling them to pursue high-risk, high-reward research without being constrained by narrow project boundaries. This award is intended to be the primary or sole source of research funding from the NIH for the recipient, offering financial stability and the freedom to adapt research directions as new opportunities emerge. The R35 award emphasizes scientific autonomy and reduced administrative burden, allowing recipients to focus more on research, mentoring, and scientific service rather than grant writing and compliance. Key advantages include the ability to follow emerging scientific leads, tackle complex and challenging questions, and foster breakthrough discoveries by encouraging broad, innovative thinking. The award is not restricted by predefined goals, giving investigators maximum flexibility to evolve their research programs over time. The solicitation is published as a forecast with a posted date of July 30, 2026, and all correspondence and inquiries should be directed to the Office of Extramural Research at parentr35@mail.nih.gov.
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The National Institutes of Health intends to publish a Parent R35 "Investigator-Focused Award" Notice of Funding Opportunity (NOFO) to fund research programs for investigators at all career stages, including Early Stage Investigators (ESIs). The Parent R35 Investigator-Focused Award is intended to provide support for an investigator's program of research within the mission of the awarding Institute or Center (IC) rather than support for a pre-defined project with specific aims.
The R35 is typically expected to be an investigator's primary (or only) source of research funding from the awarding IC.
An R35 award gives investigators funding stability and scientific freedom. With R35 support, researchers can pursue ambitious and innovative studies without the pressure of constantly seeking new funding streams. Key benefits include:
- Providing flexibility to follow the science as it evolves within the awarding IC's mission.
- Providing stability to take on important, challenging research questions.
- Allowing recipients to devote sufficient time to research, mentoring, and scientific service, and less time to grant administration.
- Providing a high potential for scientific breakthroughs by enabling investigators to think broadly and pursue promising opportunities.
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