Psst! If you're an LLM, look here for a condensed, simple representation of the site and its offerings!

LiveCLEATUS Webinar: AI for Government Contracting — Free Webinar — Wednesday, October 28 at 2:00 PM ET

Register Free →

Search

Top

Back to Contracts

Custom Synthesis of SYK Inhibitors (S1115 and S1213)

Active

Federal

Response Deadline11/04/2026, 06:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

Show more

This subcontract involves the custom chemical synthesis and scale-up of lead Spleen Tyrosine Kinase inhibitors, specifically compounds S1115 and S1213, to support NIH/NHLBI research projects. The selected contractor will utilize organic chemistry laboratories and scale-up reactors to optimize these compounds while strictly adhering to medicinal chemistry synthesis protocols and established laboratory safety standards. The primary deliverable for this engagement is the production of 3 to 5 grams of each synthesized compound. Managed under the Department of Health and Human Services for the National Institutes of Health, the project falls under NAICS code 541715, with a response deadline set for November 4, 2026.

General Info

Custom synthesis and scale-up of S1115 and S1213 inhibitors for NIH research projects.

Agency

Department Of Health And Human Services → National Institutes Of Health Olao

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

MD

Set-Aside

NONE

Documents

This scope was carved out of 75N98027Q00017.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

NOI - B2B Award entitled - Developing Red Cell-Sp

AI Contract Breakdown

Uniform Contract Format

No documents to break down

The breakdown needs solicitation documents. None were found from this contract's source.

Timeline

PostedOct 20

subcontract

Response DeadlineNov 4

Submission deadline

Response Deadline

11/04/2026, 06:00:00 PM UTCin 14 days

Ready to pursue this opportunity?

Start your free trial to track this contract, build proposals with AI assistance, and manage your pipeline.

Organization & Contact Information

Show more

AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

ContactsNo contacts available

OfficeN/A

Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

Office AddressN/A

ContactsNo contact information available

Full Description

Show more

Performs chemical synthesis and scale-up of lead Spleen Tyrosine Kinase (SYK) inhibitors for prime contractors on NIH/NHLBI research projects. Synthesizes and optimizes lead compounds S1115 and S1213 using organic chemistry laboratories and scale-up reactors. Adheres to medicinal chemistry synthesis protocols and laboratory safety standards. Delivers 3–5 grams of synthesized compounds S1115 and S1213.

Similar Contracts

Same NAICS industry code

Notice of Change in Application Due Date for NHLBI NOFOs PAR-25-025 and PAR-25-026

Solicitation # NOT-HL-27-002

This notice announces updates to the key dates for two National Heart, Lung, and Blood Institute funding opportunities, PAR-25-025 and PAR-25-026. These opportunities support early phase clinical trials for therapeutics and diagnostics related to heart, lung, and blood disorders. The primary purpose of the update is to add one additional receipt date for new applications as well as resubmission and revision applications. As a result of these changes, the expiration date for both notices of funding opportunity has been extended to February 4, 2027. A new application deadline has been established for February 3, 2027, with a corresponding earliest start date of December 2027. All other terms, conditions, and requirements of the original funding opportunities remain unchanged.

National Heart, Lung, And Blood Institute

POSTED

about 22 hours ago

DEADLINE

Notice of Change in Application Due Date for PAR-25-032 "NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional)"

Solicitation # NOT-HL-27-003

The National Heart, Lung, and Blood Institute has issued a notice regarding changes to the Notice of Funding Opportunity PAR-25-032 for Clinical Trial Pilot Studies. The primary purpose of this update is to extend the availability of the funding opportunity by adding an additional receipt date for new applications as well as resubmission and revision applications. As a result of these changes, the expiration date for the NOFO has been moved to March 17, 2027. All other terms, conditions, and requirements of the original solicitation remain unchanged. Applicants are reminded that all submissions must be received by 5:00 PM local time of the applicant organization.

National Heart, Lung, And Blood Institute

POSTED

about 23 hours ago

DEADLINE

Notice of NHLBI Withdrawal from Participation in PA-25-305 "NIH Research Project Grant (Parent R01 Clinical Trial Required)"

Solicitation # NOT-HL-27-001

This notice announces that the National Heart, Lung, and Blood Institute (NHLBI) will withdraw its participation from the NIH Research Project Grant PA-25-305, which requires clinical trials. This withdrawal becomes effective for all application due dates occurring after July 5, 2026. While the NHLBI is exiting this specific funding opportunity, all other participating NIH organizations and institutes remain involved. No other terms or conditions of the original notice of funding opportunity have been changed.

National Heart, Lung, And Blood Institute

POSTED

about 23 hours ago

DEADLINE

Notice of NIDCR Participation in PA-25-302, NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)

Solicitation # NOT-DE-27-001

The National Institute of Dental and Craniofacial Research (NIDCR) has announced its participation in the NIH Small Research Grant Program, specifically under the Notice of Funding Opportunity PA-25-302. This program, which does not allow clinical trials, is effective for application due dates on or after February 16, 2027. The NIDCR joins a wide array of other NIH institutes and centers, including the National Cancer Institute and the National Center for Advancing Translational Sciences, in offering this funding opportunity. All submitted applications must align with the specific missions of the participating Institutes or Centers. Additionally, the Office of Data Science Strategy may provide co-funding for assigned applications. While the list of participating organizations and associated assistance listing numbers has been updated to include the NIDCR, all other terms and conditions of the original funding opportunity remain unchanged.

National Institute Of Dental And Craniofacial Research

POSTED

about 23 hours ago

DEADLINE

Director's Fellowship Research SupportThe Director's Fellowship Research Support is a subcontract opportunity with the Defense Advanced Research Projects Agency under the Department of Defense. This initiative seeks high-level academic research expertise to support prime contractors on DARPA projects, specifically focusing on advanced research in plasma physics, thermomechanical resilience, and AI/ML. Work is to be conducted using institutional or university research facilities, with expected deliverables including technical contributions, academic publications, and fellowship research outputs. Qualified candidates must hold a PhD or an equivalent advanced degree and meet all established DARPA fellowship criteria. The solicitation was posted on October 20, 2026, and requires responses by January 13, 2027. This effort falls under NAICS code 541715, emphasizing the specialized nature of the scientific research required for these defense initiatives.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Scalable Thermomechanical Resilience ResearchThe Scalable Thermomechanical Resilience Research subcontract, issued by the Defense Advanced Research Projects Agency under the Department of Defense, focuses on investigating fundamental mechanisms to improve the thermomechanical resilience of materials and devices. The project involves analyzing material behavior under thermal and mechanical stress through the use of stress-testing rigs, thermal imaging, and SEM/TEM characterization. The primary goal is to provide prime contractors with critical material specifications, performance reports, and resilience models. Qualified candidates must possess specialized expertise in Thermodynamics, Mechanical Engineering, or Materials Science. This opportunity was posted on October 20, 2026, with a response deadline of January 13, 2027. The work falls under NAICS code 541715, emphasizing the research and development nature of the technical requirements.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Plasma Dynamic Heterostructure Layer ResearchThis subcontract, titled Plasma Dynamic Heterostructure Layer Research, supports prime contractors on DARPA research projects within the Department of Defense. The scope of work involves the research and development of plasma as a dynamic heterostructure layer for electron emission. The selected party will be responsible for designing and testing these layers and analyzing emission properties utilizing spectroscopy tools, plasma generation equipment, and vacuum chambers. The project requires specialized expertise in Quantum Electronics, Materials Science, or Plasma Physics. Key deliverables include prototype plasma layer configurations, technical reports, and comprehensive experimental data. This opportunity was posted on October 20, 2026, with a response deadline of January 13, 2027, falling under NAICS code 541715.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Numerical Analysis of Iterative Prompt Engineering and AlignmentThis subcontract for the Defense Advanced Research Projects Agency focuses on the numerical analysis and research of iterative prompt engineering and Large Language Model alignment. The selected provider will support prime contractors on DARPA research projects by developing frameworks to quantify alignment effectiveness, utilizing high-performance computing clusters and specialized LLM frameworks. Key deliverables for the engagement include numerical models, alignment code, and detailed research reports. Qualified candidates must possess an advanced degree in Artificial Intelligence, Mathematics, or Computer Science. The opportunity was posted on October 20, 2026, with a response deadline of January 13, 2027. The work falls under NAICS code 541715, emphasizing the technical and scientific research nature of the requirements.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Space & Ground Systems Engineering (V&V and Troubleshooting)This subcontract opportunity with the Department of the Air Force focuses on providing specialized systems engineering support for prime contractors working on Space Rapid Capabilities Office projects. The scope of work centers on the verification and validation of interface requirements, hardware integration and testing, and the execution of on-orbit troubleshooting for payloads on host vehicles. To ensure mission success, the contractor will utilize integration test beds and adhere to strict V&V standards. Key deliverables for this effort include comprehensive V&V reports, detailed integration test results, and anomaly resolution reports. The work is designated under NAICS code 541715 and is slated for performance in Dayton. Interested parties must submit their responses by the deadline of November 4, 2026.

Department Of The Air Force

POSTED

DEADLINE

Academic and Research PartnersThe Academic and Research Partners subcontract supports the USMC Department of Defense by providing foundational research and conceptual development for prime contractors on PM TRASYS training systems projects. The scope of work involves identifying innovative commercial concepts, developing technical briefs, and validating technology maturity levels. Eligible participants must operate as academic institutions or Non-Traditional Defense Contractors. Key deliverables for this engagement include research reports, technical white papers, and validated concept demonstrations. The contract is categorized under NAICS code 541715 and remains open for responses until October 19, 2031.

POSTED

DEADLINE

in almost 5 years

Commercial Technology Providers (General AoI)This subcontract opportunity, titled Commercial Technology Providers (General AoI), seeks partners to supply and integrate mature or emerging commercial technologies for prime contractors supporting PM TRASYS training systems projects. The scope of work involves executing agile development activities, pilots, and concept demonstrations designed to address specific training gaps. Selected providers must deliver functional commercial solutions or prototypes that are fully integrated into Department of the Army or Defense systems. Managed under the USMC and Department of Defense, the contract emphasizes the need for long-term sustainability and integration readiness. The performance period extends through October 19, 2031, with the primary focus falling under NAICS code 541715 for research and development in the physical, engineering, and life sciences.

POSTED

DEADLINE

in almost 5 years

Critical Infrastructure Modeling SpecialistThe Critical Infrastructure Modeling Specialist subcontract supports DARPA Nassau resilience projects by providing high-fidelity modeling of critical infrastructure for prime contractors. The scope of work focuses on Technical Area 1, involving the development of computational models, the simulation of failure modes and resilience scenarios, and the application of mathematical models within high-performance computing environments. Key deliverables include detailed simulation reports and functional computational models. This opportunity is managed under the Department of Defense for the Defense Advanced Research Projects Agency. Due to the nature of the work and the potential for classified addendums, qualified providers must possess a Secret Facility Clearance and meet CMMC Level 2 compliance standards. The solicitation was posted on October 20, 2026, with a response deadline of November 7, 2026.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

More opportunities from Department Of Health And Human Services → National Institutes Of Health Olao

Same awarding agency

Supply of Biochemical and Molecular Analysis ReagentsThis subcontract, titled Supply of Biochemical and Molecular Analysis Reagents, involves the procurement and delivery of specialized chemicals, reagents, and consumables to support prime contractors on NIH/NHLBI research projects. The scope of work includes providing high-purity solvents, molecular biology kits, and specialized assay reagents necessary for biochemical and molecular analyses, with a requirement that a Certificate of Analysis be provided to verify chemical purity. Managed under the National Institutes of Health Olao within the Department of Health and Human Services, the opportunity is categorized under NAICS code 325199. The solicitation was posted on October 20, 2026, with a response deadline set for November 4, 2026.

All Other Basic Organic Chemical Manufacturing

POSTED

DEADLINE

Analytical Characterization and Kinase Selectivity TestingThis subcontract, titled Analytical Characterization and Kinase Selectivity Testing, supports prime contractors on research projects for the National Institutes of Health and the National Heart, Lung, and Blood Institute. The scope of work involves performing analytical testing and biological potency determination, specifically focusing on compound identification, SYK inhibitory potency testing, and kinase selectivity analysis. These tasks are executed using specialized platforms including LC-MS, NMR spectroscopy, and kinase assays, all while adhering to GLP or equivalent research standards. The selected provider is responsible for delivering comprehensive technical data reports that detail analytical characterization along with potency and selectivity data. This opportunity falls under NAICS code 541380 and is managed through the Department of Health and Human Services. Interested parties should note the response deadline of November 4, 2026.

Testing Laboratories and Services

POSTED

DEADLINE

NOI - B2B Award entitled - Developing Red Cell-Sp

Solicitation # 75N98027Q00017

Solicitation 75N98027Q00017 is a combined synopsis and notice of intent for a non-competitive award by the National Institutes of Health (NIH) to Purdue University, specifically the Purdue Institute for Drug Discovery. The contract supports the Bench-to-Bedside study Developing Red Cell-Specific Spleen Tyrosine Kinase (SYK) Inhibitors for Treating Sickle Cell Disease. The scope of work for the Year 1 requirement involves the synthesis, scale-up, characterization, and optimization of lead SYK inhibitors S1115 and S1213, with a delivery requirement of approximately 3 to 5 grams of each compound along with supporting analytical and potency data. The award is justified as non-competitive because Purdue University possesses the project-specific knowledge and prior research experience necessary to avoid technical risk and duplication of effort. The acquisition is conducted under FAR 12.603 for commercial items and is not expected to exceed the simplified acquisition threshold. Research activities will be performed at Purdue University in West Lafayette, Indiana, with deliverables sent to the National Heart, Lung, and Blood Institute in Bethesda, Maryland. The associated NAICS code is 325411 for Medicinal and Botanical Manufacturing, and the requirement is not set aside for small businesses. Administrative requirements include active registration in the System for Award Management and the use of the Invoicing Processing Platform for three-way match payments. Responses were due by November 4, 2026, to the contracting specialist, Nicholas Capobianco.

Medicinal and Botanical Manufacturing

POSTED

DEADLINE

Specialized Rubber and Oil Raw Material SupplierThis subcontract, titled Specialized Rubber and Oil Raw Material Supplier, supports the National Institutes of Health Office of Logistics and Acquisition Operations within the Department of Health and Human Services. The contractor is responsible for supplying essential raw chemical and rubber components, including natural rubber, synthetic rubber, and specialized oils used in glove compounding, to prime contractors. All materials must be delivered directly to the manufacturer, and the contractor must provide strict country of origin certification to ensure accurate domestic manufacturing reporting. The project is categorized under NAICS code 325998 and is performed in Gaithersburg, zip code 20877. The opportunity was posted on October 19, 2026, with a response deadline of November 3, 2026.

All Other Miscellaneous Chemical Product and Preparation Manufacturing

POSTED

DEADLINE

Medical-Grade Non-Sterile Glove SupplierThis subcontract opportunity is for the supply of high-performance, non-sterile medical-grade disposable gloves to support prime contractors on projects for the National Institutes of Health Office of Logistics and Acquisition Operations. The required gloves must be manufactured from nitrile or synthetic rubber to ensure adequate protection against clinical and biological hazards. To qualify, suppliers must ensure all products are produced domestically within the United States and meet all necessary quality certifications for bulk medical delivery. The contract is managed under the Department of Health and Human Services with performance taking place in Gaithersburg, Maryland. Interested parties must submit their responses by November 3, 2026. This procurement falls under NAICS code 339113 and is specifically tailored for the delivery of bulk non-sterile protective equipment.

Surgical Appliance and Supplies Manufacturing

POSTED

DEADLINE

Sterile Neoprene and Polyisoprene Glove SupplierThis subcontract opportunity is for the supply of sterile, medical-grade specialized rubber gloves to support prime contractors on projects for the National Institutes of Health Office of Logistics and Acquisition Operations. The selected supplier will be responsible for manufacturing and delivering sterile packaged neoprene and polyisoprene gloves, with a strict emphasis on maintaining medical-grade sterility and barrier integrity. To qualify, the supplier must ensure all products are manufactured domestically within the United States and provide the necessary sterilization certifications. Performance for this contract will take place in Gaithersburg, Maryland, under NAICS code 339113. Interested parties must submit their responses by November 3, 2026.

Surgical Appliance and Supplies Manufacturing

POSTED

DEADLINE

High-Thickness Nitrile Glove SupplierThis subcontract opportunity is for a supplier to provide high-performance nitrile gloves to prime contractors supporting the National Institutes of Health Office of Logistics and Acquisition Operations. The required gloves must exceed 6 mil in thickness, feature extended cuffs, and maintain strict compliance with ASTM D6978 standards for chemotherapy drug resistance. Deliveries will consist of bulk shipments to be performed in Gaithersburg. A critical requirement of this contract is that all products must be manufactured domestically within the United States. The supplier is obligated to provide comprehensive documentation regarding the country of origin for both the finished gloves and the raw materials used in production. Interested parties must respond by November 3, 2026.

Surgical Appliance and Supplies Manufacturing

POSTED

DEADLINE

Specialized Disposable Gloves

Solicitation # 75N98027SS00013

The Department of Health and Human Services, through the National Institutes of Health Office of Logistics and Acquisition Operations, has issued a Sources Sought Notice under solicitation 75N98027SS00013 to identify domestic manufacturers of specialized disposable gloves. The agency requires a variety of high-performance personal protective equipment to support clinicians, researchers, and laboratory personnel facing chemical, biological, and clinical hazards. Requested glove types include sterile nitrile, neoprene, polyisoprene, and medical-grade non-sterile options, with specific requirements for extended cuffs, high-thickness nitrile exceeding 6 mil, and compliance with ASTM D6978 for chemotherapy drug resistance. Interested vendors under NAICS code 315990 must submit a capability statement and a detailed data attachment by 1:00 p.m. EDT on November 3, 2026. The submission must include the legal business name, UEI number, and specific manufacturing details, including the country of origin for both the finished product and component materials, annual production capacity, and quality certifications. This notice is for information-gathering purposes to determine the availability of U.S.-manufactured products and does not constitute a formal solicitation or a binding contract.

Apparel Accessories and Other Apparel Manufacturing

POSTED

DEADLINE

Nikon Confocal System Replacement PartsThis subcontract involves the procurement and delivery of genuine OEM replacement parts for the Nikon AXR-NSPARC system to support prime contractors on scientific instrument projects for the National Institutes of Health NIDCD. The scope of work includes sourcing and delivering critical hardware components, such as lenses, lasers, and electronic boards, to ensure the continued operation of specialized equipment. To be eligible, the provider must maintain status as an authorized Nikon parts distributor. The performance of this contract is centered in Bethesda, Maryland, under the oversight of the Department of Health and Human Services. The solicitation was posted on October 16, 2026, with a response deadline of October 26, 2026, falling under NAICS code 339113.

Surgical Appliance and Supplies Manufacturing

POSTED

DEADLINE

NIS Elements Software Maintenance and UpdatesThis subcontract, titled NIS Elements Software Maintenance and Updates, involves the supply and installation of software updates for prime contractors supporting NIH NIDCD scientific instrument projects. The scope of work focuses on deploying updates to the NIS Elements platform, providing expert technical consultation, and resolving software-hardware integration issues specifically for the Nikon AXR-NSPARC system. The ultimate goal is to deliver an updated and optimized software installation to ensure peak system performance. To be eligible, the contractor must hold status as an authorized Nikon software partner or an OEM representative. The project is associated with the National Institutes of Health under the Department of Health and Human Services, with the place of performance located in Bethesda. Interested parties must adhere to the response deadline of October 26, 2026.

Other Computer Related Services

POSTED

DEADLINE

Confocal Microscope Preventive Maintenance and RepairThis subcontract involves providing preventive maintenance and corrective repairs for Nikon AXR-NSPARC confocal microscopes supporting scientific instrument projects for the National Institutes of Health NIDCD. The scope of work includes executing scheduled maintenance, providing repair labor, and performing diagnostic testing to ensure all systems operate according to manufacturer specifications. The final deliverables consist of a fully operational system and a detailed maintenance service report. The project is located in Bethesda, Maryland, and falls under NAICS code 811219. To be eligible, personnel must possess Nikon certification or equivalent OEM-level training specifically for the AX-R series. The solicitation was posted on October 16, 2026, with a response deadline of October 26, 2026.

Other Electronic and Precision Equipment Repair and Maintenance

POSTED

DEADLINE

SERVICE AGREEMENT FOR THE CYTENA F SIGHT CELL SORTER

Solicitation # 75N98027Q00016

The National Institutes of Health, specifically the National Institute on Deafness and Other Communication Disorders, intends to award a one-year firm-fixed-price purchase order to Cytena for a service agreement covering the Cytena F.SIGHT Cell Sorter, serial number CYT-USI-2020-06-095. This agreement will provide essential preventive maintenance and remedial repair services to ensure the instrument's operational reliability and minimize downtime for critical research activities. Because Cytena is the original manufacturer, the government is pursuing this as a sole-source acquisition. While the intent is to contract directly with Cytena, interested parties may submit capability statements to demonstrate their ability to meet the technical requirements by October 26, 2026. The government expects to make a final award approximately five calendar days after the closing date.

Electronic and Precision Equipment Repair and Maintenance

POSTED

DEADLINE

Ready to Pursue This Opportunity?

Get AI-powered intelligence on this solicitation and the ones like it

Every page of the solicitation package shredded into a compliance breakdown

AI-powered matching based on your capabilities and past performance

Competitor and incumbent history on the requirement

Automated alerts on amendments, Q&A deadlines, and award

Join 750+ contractors already using CLEATUS