Custom Synthesize Antibody - Drug Conjugates

The Texas Tech University Health Sciences Center is soliciting proposals for the custom synthesis of Antibody-Drug Conjugates targeting the c-MYC oncogene, with services defined in Section 5.4 of the solicitation. The contract, identified as RFP 739-SL3800457, is open for submission until May 26, 2026, and is issued under the NAICS code 325414 for pharmaceutical and biological product manufacturing. Proposals must include a signed Execution of Offer, a HUB Subcontracting Plan if applicable, an Addenda Checklist, and Vendor Information forms, all submitted either electronically via the TechBid portal or as a bundled printed copy with a USB drive. The evaluation is based on a best value trade-off approach, with technical specifications accounting for 50 percent of the score, pricing for 30 percent, and experience and reputation for 20 percent. Award will not be based solely on lowest cost, with emphasis placed on quality, long-term value, and conformity to TTUHSC’s specifications, including conjugation chemistry, DAR optimization, and purification to achieve high monomeric purity. Deliverables include a fully characterized ADC product with a Certificate of Analysis and a Final Project Report, delivered in three phases: feasibility, pilot synthesis, and scale-up, with title and risk of loss transferring only upon physical receipt at TTUHSC’s Lubbock, Texas facility. All work must comply with federal, state, and local laws, including OSHA standards, Texas Hazard Communication Act requirements for MSDS submissions, and export controls under ITAR and EAR. Contractors must adhere to TX-RAMP cybersecurity standards and avoid engagement with foreign adversaries. Intellectual property developed under the contract is considered a work made for hire, fully assigned to TTUHSC. Key personnel identified in the proposal require approval and cannot be substituted without written consent. The contract mandates compliance with Texas ethics reporting for agreements valued at $1 million or more via Form 1295 and requires affirmation of child support compliance. Packaging and marking requirements are limited to inclusion of the purchase order number and shipping details on all documentation and shipments, with no military standards applied. Payment terms are Net 30 days, with invoices directed to the TTUHSC Purchasing Office in Lubbock. No formal contract type is designated, but pricing structure implies a fixed-price arrangement. There are no options, extensions, or modification clauses, and no CAGE or UEI