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Custom Homing Peptide Synthesis and AAV Capsid Modification

Active
Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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This subcontract for the Department of Veterans Affairs, specifically supporting the Harry S Truman Memorial Veterans Hospital, involves the synthesis of targeting peptides and genetic engineering services. The scope of work includes designing homing peptides, modifying AAV capsid genomes for peptide display, and producing modified viral vector prototypes. These activities are to be conducted using molecular cloning tools and DNA/RNA synthesis platforms within BSL-2 facilities. The selected provider must hold BSL-2 certification to deliver the required modified AAV vector constructs and synthesized peptide sequences. Performance of the contract will take place in Columbia, Missouri, under NAICS code 325414. The solicitation was posted on October 21, 2026, with a response deadline of November 4, 2026.

General Info

BSL-2 provider synthesizes targeting peptides and genetic engineering services for Veterans Affairs.

NAICS

325414 - Biological Product (except Diagnostic) Manufacturing

Place of Performance

Columbia, PA, 65201, USA

Set-Aside

NONE

Documents

This scope was carved out of 36C24E27Q0009.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

AJ12--Development/Production - Kidney GEC-Specific AAV Vector

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Organization & Contact Information

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AgencyDepartment Of Veterans Affairs → Rpo East (36C24E)
ContactsNo contacts available
OfficeN/A
Office AddressN/A
ContactsNo contact information available

Full Description

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Synthesizes targeting peptides and performs genetic engineering for prime contractors on VA Harry S Truman Memorial Veterans Hospital biotechnology projects. Designs homing peptides, modifies AAV capsid genomes for peptide display, and produces modified viral vector prototypes using DNA/RNA synthesis platforms and molecular cloning tools in BSL-2 facilities. Requires BSL-2 certification. Delivers modified AAV vector constructs and synthesized peptide sequences.

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POSTED

20 days ago

DEADLINE

in 20 days
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More opportunities from Department Of Veterans Affairs → Rpo East (36C24E)

Same awarding agency

NAICS: 541714
New
Federal
AJ12--Development/Production - Kidney GEC-Specific AAV Vector
Solicitation # 36C24E27Q0009
The Department of Veterans Affairs is issuing a Sources Sought notice to identify capable vendors for the development and production of a kidney glomerular endothelial cell specific adeno-associated virus AAV vector. This project, funded by a VA ORD Merit award, aims to create a homing peptide enabled vector platform to target the glomerular endothelium to treat kidney injury and disease while reducing off target transduction. The scope of work is divided into three primary tasks: the engineering and incorporation of targeting peptides into the AAV capsid, testing vector binding and internalization in kidney tissue slices, and evaluating the specificity and efficiency of the modified vector through bioluminescence imaging and in vivo biodistribution studies. Qualified contractors must possess extensive onsite resources, including BSL 2 laboratories, specialized DNA and RNA facilities, and advanced instrumentation such as the Agilent Fragment Analyzer and various qPCR platforms. Vendors must demonstrate proven success in animal and human cell vector delivery and maintain full compliance with AAALAC and FELASA health standards. The government requires quarterly reporting, weekly videoconferences, and biannual face to face meetings. All generated data will be subject to Government Purpose Rights, and contractors must adhere to strict federal records management and information security protocols. Interested parties must submit a capability statement, relevant literature, and socio economic status details under NAICS 541714 by November 4, 2026.
Research and Development in Biotechnology (except Nanobiotechnology)

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about 4 hours ago

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in 14 days
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