Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)

The National Institutes of Health, through the Gabriella Miller Kids First Pediatric Research Program, is inviting applications to submit pediatric samples for advanced genomic and molecular analyses aimed at uncovering the genetic foundations of childhood cancers and congenital anomalies. Applicants are encouraged to propose sequencing of existing pediatric cohorts to investigate somatic and germline genetic contributions to these conditions, explore the molecular links between congenital anomalies and elevated cancer risk, or broaden the spectrum of pediatric disorders represented in the Kids First Data Resource. The program supports a wide range of technologies including whole genome, exome, and transcriptome sequencing, as well as clinical-grade sequencing, long-read sequencing, proteomics, and epigenomic assays on tumor or affected tissues, provided the scientific rationale is strong. There is a specific emphasis on expanding representation of populations already included in existing Kids First projects to enhance the diversity and utility of the data. All generated data, along with associated clinical and phenotypic information, will be deposited into the Kids First Data Resource Center, making it openly available to the broader research community to accelerate discoveries in pediatric health. This opportunity is issued under solicitation PAR-27-071, with a submission deadline of January 11, 2027, and is not open for clinical trials. Applications must be submitted through Grants.gov, and inquiries can be directed to the designated point of contact at the NIH. The initiative is part of a larger federal effort under the U.S. Department of Health and Human Services to advance pediatric research through open data sharing and cutting-edge genomic technologies.