GREGoRi Innovation Projects (U01 Clinical Trial Optional)

The GREGoRi Innovation Projects initiative, funded by the National Institutes of Health under the Department of Health and Human Services, aims to revolutionize the diagnosis of rare genetic diseases by supporting highly innovative experimental and computational approaches that go beyond current methodologies. This funding opportunity encourages the development and rigorous testing of novel tools, molecular technologies, and analytical frameworks capable of identifying causal genes or variants in rare disorders with transformative speed and accuracy. The program seeks proposals that challenge existing paradigms in rare disease genomics, prioritizing groundbreaking ideas with the potential to significantly improve diagnostic outcomes and expand understanding of genetic mechanisms. Applicants must submit proposals by the deadline of October 30, 2026, through the solicitation number RFA-HG-27-013, which is structured as a U01 award with clinical trials being optional. The initiative is open to federal and non-federal entities without set-asides, and funding recipients are expected to operate across the United States with no specific geographic restrictions. All inquiries should be directed to the designated point of contact at nhgri-gregor@mail.nih.gov or by phone at 301-402-2541. Further details and the official application portal are accessible via the provided grants.gov link.