Efficacy Study – Adenine Diet-Induced Kidney Disease Model
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The contract outlines a preclinical efficacy study to evaluate a NNMT inhibitor in a mouse model of adenine-induced chronic kidney disease, focusing on therapeutic assessment through controlled dosing, longitudinal monitoring, and systematic sample collection. The study requires detailed protocols for administering the inhibitor, tracking disease progression via biochemical and histological endpoints, and analyzing the resulting data to determine efficacy, with all procedures aligned to industry standards for preclinical research. The work is to be performed under a subcontract arrangement, with the National Institutes of Health under the Department of Health and Human Services as the overseeing entity, and is classified under NAICS code 541690, indicating it falls within other scientific research and development services. Responses are due by August 19, 2026, following a posting date of August 4, 2026.
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