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Evaluation of a Lead NNMT Inhibitor in Humanized M

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75N98026Q00941Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institutes of Health, Office of the Director, intends to award a non-competitive, firm-fixed price contract to GemPharmatech LLC for the evaluation of a lead NNMT inhibitor using a humanized nicotinamide N-methyltransferase mouse model, a model uniquely developed and maintained by GemPharmatech under prior NIH funding. This acquisition is conducted under streamlined commercial item procedures and is not expected to exceed the simplified acquisition threshold, with authority derived from FAR 12.603 and 41 U.S.C. 1901, and justified under the sole source exception for unique capabilities, as GemPharmatech is the only entity with the cryopreserved sperm and breeding resources necessary to regenerate the required mouse colony essential for generating scientifically relevant efficacy data due to the inhibitor's species-specific activity. The solicitation number is 75N98026Q00941, issued as a combined synopsis and solicitation without competitive procedures, and responses are due by August 19, 2026. The work falls under NAICS code 541714 for Research and Development in Biotechnology with a small business size standard of 1,000 employees, and this requirement is not set aside for small business. The contract will be managed by the NIH Office of Acquisitions based in Bethesda, Maryland, with the primary point of contact being Johnstona C. Johnston, reachable via email. All provisions and clauses follow those in effect through the Federal Acquisition Circular dated August 4, 2026, and the notice serves as the complete and only solicitation document; no additional written solicitation will be issued. The performance location is not specified beyond the federal agency's administrative details.

General Info

NIH awards GemPharmatech sole-source contract to evaluate NNMT inhibitor using unique mouse model.

Agency

Department Of Health And Human Services → National Institutes Of Health OlaoView Agency

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)View NAICS

Place of Performance

MD

Set-Aside

NONE

Documents

(1)

Sol_75N98026Q00941.pdf

PDF

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao
Contacts1 person available
OfficeBETHESDA, MD, 20892, USA
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health Olao
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Office AddressBETHESDA, MD, 20892, USA
Contacts
JOHNSTON JADDUA C
contact@example.gov
+1 (555) 000-0000

Full Description

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(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested, and a separate written solicitation will not be issued.

(ii) The solicitation number is 75N98026Q00941. This solicitation is issued as a Notice of Intent (NOI) for a non-competitive combined synopsis/solicitation to award a contract or purchase order without providing for full and open competition.

This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold. Additional authority includes 41 U.S.C. 1901 and FAR 6.302-3(a)(2)(ii).

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, intends to negotiate and award a Firm-Fixed Price on a non-competitive basis GemPharmatech LLC 11175 Flintkote AVE STE B San Diego, California 92121-1209, United States for GemPharmatech is the only known source capable of providing the required services because it developed the humanized nicotinamide N-methyltransferase (hNNMT) mouse model under prior NIH-funded work (PO 75N95023P00824) and maintains the cryopreserved sperm and breeding resources necessary to regenerate the colony. The NCATS lead NNMT inhibitor exhibits lower activity against mouse NNMT than human NNMT; therefore, evaluation in mice expressing human NNMT is required to generate scientifically relevant efficacy data.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular August 4, 2026

(iv) The associated NAICS code is 541714 ¿ Research and Development in Biotechnology (except Nanobiotechnology) and the small business size standard is 1,000 employees. This requirement is not set aside for small business.

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Federal
Firmware, Software Updates, and Cybersecurity Patching for Lab InstrumentsThe contract pertains to the application of software and firmware updates, along with cybersecurity patches, specifically for Agilent 6546 LC/Q-TOF and 1290 LC systems to ensure continued operational reliability and adherence to cybersecurity standards. This work is critical for maintaining the integrity of laboratory instrumentation used in high-stakes research environments, preventing vulnerabilities that could compromise data security or system functionality. The scope is narrowly focused on these two instrument models, requiring specialized technical expertise to implement updates without disrupting ongoing experiments or analytical workflows. The contract is classified as a subcontract under NAICS code 541512, indicating a focus on computer systems design and related services. It is issued by the National Institutes of Health Office of Laboratory Animal Welfare under the Department of Health and Human Services, with a response deadline of August 18, 2026. Although specific location and point of contact details are unspecified, the requirement implies that services may need to be delivered on-site or through secure remote access protocols to maintain compliance and minimize system downtime. The absence of set-aside classification suggests the opportunity is open to all eligible contractors capable of meeting the technical and security demands of the task.
Computer Systems Design Services

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1 day ago

DEADLINE

in 14 days
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NAICS: 541380
New
Federal
On-Site Technical Support and Instrument Performance VerificationThe contract requires on-site technical support to execute operational qualification and performance verification for an LC/Q-TOF system, ensuring the instrument meets established performance benchmarks under real-world operating conditions. The scope includes comprehensive troubleshooting to identify and resolve system anomalies, with all activities conducted in strict alignment with NIH standards for documentation and reporting. Deliverables must include detailed records of each test, verification step, and corrective action taken, submitted in a format compliant with federal research instrumentation protocols. This subcontract is issued under the NAICS code 541380 and is part of the Department of Health and Human Services’ mission to maintain high-fidelity analytical instrumentation for critical scientific research. The response deadline is August 18, 2026, and performance must occur at the NIH facility or designated location, though exact geographic details are unspecified. The work demands specialized expertise in liquid chromatography and quadrupole time-of-flight mass spectrometry, with an emphasis on adherence to regulatory and quality assurance requirements to support the integrity of NIH-funded studies.
Testing Laboratories and Services

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1 day ago

DEADLINE

in 14 days
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NAICS: 811212
New
Federal
Agilent LC/Q-TOF Mass Spectrometer Maintenance & Calibration ServicesThe contract entails annual maintenance, repair, calibration, and performance verification services for an Agilent 6546 LC/Q-TOF mass spectrometer paired with a 1290 Infinity II LC system. Services include scheduled on-site visits, routine cleaning, instrument tuning, and comprehensive system checks to ensure optimal operational performance and analytical accuracy. All activities are designed to uphold the instrument’s precision, reliability, and compliance with required standards throughout the contract period. This subcontract is issued under the National Institutes of Health, part of the Department of Health and Human Services, with a NAICS code of 811212 for laboratory and testing services. The opportunity was posted on August 3, 2026, with a response deadline of August 18, 2026. No specific location or point of contact is provided, and the place of performance remains unspecified. The contract does not indicate a set-aside designation, and all work is expected to be performed in accordance with Agilent’s service protocols for the listed instrumentation.
Computer and Office Machine Repair and Maintenance

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1 day ago

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in 14 days
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NAICS: 541715
New
Federal
Installed Upgrades and System Enhancements SupportThe contract titled Installed Upgrades and System Enhancements Support requires the successful bidder to provide comprehensive support for the installation and integration of software or hardware upgrades to existing instrumentation systems. This includes conducting pre-installation validation to ensure compatibility and readiness, performing precise configuration of new components, executing thorough post-upgrade testing to verify operational integrity, and delivering complete documentation of all changes and results. The work is intended to maintain, enhance, and extend the functionality of critical instrumentation systems without disruption to ongoing operations. This subcontract is issued under the NAICS code 541715 and is associated with the National Institutes of Health Office of Laboratory Animal Welfare within the Department of Health and Human Services. The opportunity was posted on August 3, 2026, with a response deadline of August 18, 2026, and the performance location is unspecified, though the work clearly pertains to NIH-managed laboratory environments. All activities must be conducted in alignment with established technical and compliance standards, and the contractor is expected to deliver reliable, well-documented upgrades that meet the operational needs of federal research instrumentation.
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

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1 day ago

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in 14 days
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