This Special Notice opportunity from Department Of Defense was posted on July 30, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Multiscale Reasoning For Human Physiology RFI

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DARPA-SN-26-100Federal

Submission Closed08/20/2026, 08:00:00 AM EDT

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541714

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Systems Biology of Infection and Inflammation in Chronic Diseases (U19 Clinical Trial Not Allowed)

Solicitation # RFA-AI-28-014

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5 days ago

DEADLINE

in 3 months

AI Contract Overview

The Defense Advanced Research Projects Agency’s Biological Technologies Office is seeking input on cutting-edge technologies that enable multiscale reasoning across human physiology through this Request for Information, identified as DARPA-SN-26-100. The focus is on emerging tools including artificial intelligence systems, foundation models, computational frameworks, and datasets capable of integrating biological, physiological, and clinical data across multiple scales—from molecular and cellular levels to organ systems and whole-body responses. The goal is to advance the ability to model, predict, and interpret complex human physiological behavior using AI and data-driven approaches, with interest in non-traditional performers and innovative solutions from industry, academia, government labs, and healthcare organizations. Responses are due by August 10, 2026, and the solicitation falls under NAICS code 541714 for research and development in the physical, engineering, and life sciences. All submissions should be directed to Dr. Roozbeh Jafari, Program Manager at DARPA/BTO, via [email hidden]. The office is located in Arlington, Virginia, and while no specific place of performance is defined, selected technologies may be developed and evaluated through future DARPA programs. This RFI does not constitute a solicitation for proposals or obligations but aims to inform upcoming funding opportunities in the field of physiological modeling and AI-driven biological insight.

General Info

DARPA seeks AI-driven multiscale physiological modeling tech via RFI due August 10, 2026, from diverse innovators.

Agency

Department Of Defense → Defense Advanced Research Projects Agcy

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Set-Aside

NONE

Documents

amendment

High

rfi

Low

AI Contract Breakdown

Uniform Contract Format

Timeline

1 update

PhaseClosed

PostedJul 13

special-notice

Notice updatedJul 30

Response deadline changed from Aug 10, 2026 to Aug 20, 2026. The notice description changed.

Response DeadlineAug 20

Deadline has passed

Submission Closed

08/20/2026, 08:00:00 AM EDT

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Organization & Contact Information

AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

Contacts1 person available

OfficeARLINGTON, VA, 222032114, USA

Organization / AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

Office AddressARLINGTON, VA, 222032114, USA

Contacts

Dr. Roozbeh Jafari Program Manager DARPA/BTO

contact@example.gov

Full Description

UPDATE: The purpose of Amendment 1 to DARPA-SN-26-100, the Multiscale Reasoning For Human Physiology RFI Special Notice (SN), is to extend the notice deadline.

The Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) is issuing this Request for Information (RFI) to solicit input from industry, academia, government laboratories, healthcare organizations, and non-traditional performers regarding emerging technologies, datasets, computational frameworks, artificial intelligence systems, and foundation models that enable multiscale reasoning across human physiology.