Skip to main contentPsst! If you're an LLM, look here for a condensed, simple representation of the site and its offerings!

LiveFree Webinar — Wednesday, September 2 at 2:00 PM EDT

Register Free →
logo
Get CLEATUS

Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required)

Active
RFA-CA-27-005Grant

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

Show more

The National Cancer Institute is soliciting applications under solicitation RFA-CA-27-005 to establish the Glioblastoma Therapeutics Network. This initiative focuses on developing and testing novel therapies for adult glioblastoma, specifically targeting agents that can effectively cross the blood brain barrier. The program supports a collaborative network of teams to move therapeutic agents from pre-clinical development and investigational new drug studies into early phase clinical trials. Eligible agents include novel compounds or existing drugs repurposed for glioblastoma treatment following preclinical validation. Managed by the National Institutes of Health within the Department of Health and Human Services, this opportunity aims to bridge the gap between late pre-clinical research and Phase 0/1 clinical studies. Successful early-stage trials are intended to transition into later-stage trials using established NCI mechanisms. Interested parties must submit their applications by the deadline of October 1, 2026.

General Info

NCI seeks applications by October 1, 2026, to develop adult glioblastoma therapies.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(1)

RFA-CA-27-005-Full-Announcement.html

HTML

AI Contract Breakdown

Uniform Contract Format

What is UCF?

Uniform Contract Format (UCF) uses AI to break down any contract into standardized sections—scope, pricing, deliverables, and evaluation criteria.

Timeline

PhaseSolicitation
Posted

Solicitation

Response Deadline

Submission deadline

Response Deadline

Ready to pursue this opportunity?

Start your free trial to track this contract, build proposals with AI assistance, and manage your pipeline.

Organization & Contact Information

Show more
AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
National Institutes of Health
contact@example.gov
+1 (555) 000-0000

Full Description

Show more
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on novel therapies for adult glioblastoma (GBM). The goal is to improve the treatment of adult GBM by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them clinically. Successful early-stage trials of new drugs from this NOFO would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms.To implement this concept, a highly collaborative GBM Therapeutics Network (GTN) of cross-cutting teams will be established, each team capable of driving therapeutic agent(s) from pre-clinical development, through investigational new drugs (IND) studies, into pilot clinical studies in humans. Appropriate therapeutic agents include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following appropriate preclinical studies. The scope of the NOFO, from late pre-clinical through early (Phase 0/1) clinical studies, uniquely spans a gap in the GBM drug development process.

Similar Contracts

Same NAICS industry code

NAICS: 541715
New
DIBBS
Technical Data and Alternate Part SubmissionThis subcontract, issued by the Active Devices Division of the Department of Defense, requires the preparation and submission of comprehensive technical data packages for both approved and alternate antenna parts. The scope of work includes providing detailed specifications, test data, and OEM or distributor documentation to facilitate evaluation by the Defense Logistics Agency. The project is categorized under NAICS code 541715 and will be performed at Fort Carson, zip code 80913-4093. The solicitation was posted on August 31, 2026, with a response deadline set for September 11, 2026.
ACTIVE DEVICES DIVISION

POSTED

about 16 hours ago

DEADLINE

in 10 days
View Details
NAICS: 541715
New
Federal
ManTech special Broad Agency Announcement (sBAA): Accelerating Maritime Modernization: Innovation in Naval Manufacturing, Sustainment, and Industrial Base Capability
Solicitation # N0001426SB002
The Navy Manufacturing Technology Program is seeking innovative research and development proposals through solicitation N0001426SB002 to enhance shipbuilding and maintenance capabilities by improving speed, throughput, and industrial base resilience. The focus is on transforming shipyards, maintenance depots, and supply chain operations through breakthrough manufacturing technologies that enable faster construction, arming, and repair of naval vessels. Proposals must clearly demonstrate how they remove existing bottlenecks and strengthen the nation’s shipbuilding enterprise by increasing efficiency, adaptability, and competitiveness across the defense industrial base. This initiative is critical to sustaining and modernizing the U.S. naval industrial infrastructure to meet current and future operational demands. Proposals are due by September 16, 2026, and are open to organizations responding to the Small Business Administration Assistance program under NAICS code 541715. The solicitation is managed by the Office of Naval Research in Arlington, Virginia, with primary point of contact Stephanie L. Marsh and secondary contact Miranda Fleck for inquiries. Performance locations are not specified, allowing flexibility for applicants to propose solutions that can be implemented across various U.S. naval manufacturing and maintenance facilities. Interested parties must submit their responses via the SAM.gov portal before the deadline to be considered for funding and collaboration opportunities aimed at revolutionizing naval manufacturing.
Office Of Naval Research

POSTED

about 21 hours ago

DEADLINE

in 14 days
View Details
NAICS: 541715
New
Federal
Request for Information - Health Advisory Committees Research and Support
Solicitation # HT001126RFI0252
The Defense Health Agency, under the Department of Defense, is issuing a request for information under solicitation number HT001126RFI0252 to identify qualified vendors capable of providing Health Advisory Committees Research and Support Services. This sources-sought opportunity falls under NAICS code 541715 and is managed by the office located in Falls Church, Virginia. Interested companies must submit their responses by the deadline of September 14, 2026. The primary point of contact for this inquiry is Jeanna Butler. This process is intended to gauge market capabilities and identify potential contractors who can support the research and operational needs of health advisory committees.
Defense Health Agency

POSTED

about 21 hours ago

DEADLINE

in 13 days
View Details
NAICS: 541715
New
Federal
TTO Office-Wide Solicitation 2026
Solicitation # DARPA-PS-26-123
The Defense Advanced Research Projects Agency is issuing the TTO Office-Wide Solicitation 2026 under solicitation number DARPA-PS-26-123. This initiative aims to redefine modern warfare by accelerating the development of advanced platforms and weapons systems designed to dominate existing battlespaces and establish new ones, ensuring the United States maintains a technological velocity that adversaries cannot match. Interested parties must submit their responses by June 17, 2027. This solicitation falls under NAICS code 541715 and is managed by the TTO Office-Wide Solicitation Coordinator based in Arlington, Virginia. Further details and application procedures are available through the official government workspace link.
Defense Advanced Research Projects Agcy

POSTED

about 21 hours ago

DEADLINE

in 10 months
View Details
NAICS: 541715
New
Federal
Distributed Aperture Resilient Terminal System (DARTS)
Solicitation # W56KGU-26-R-0230
The U.S. Army, through the Product Manager Wideband Enterprise Satellite Systems, is issuing a Request for Information for the Distributed Aperture Resilient Terminal System (DARTS). The goal is to replace large, single-aperture SATCOM antennas, which are vulnerable and slow to install, with a resilient array of smaller, quickly deployable antennas. The government is seeking industry partners capable of developing a Technology Readiness Level 7 prototype using commercially available components. The system must support X-band and Military Ka-band frequencies and utilize digital signal processing to replicate the performance of larger antennas while ensuring redundancy against kinetic and electronic attacks. Interested providers must submit a white paper by September 30, 2026, detailing their proposed system architecture, key components, and the trade-offs used in their design. Responses must include technical details on digital conversion, signal processing, and control systems, specifically addressing compatibility with the IEEE-ISTO 4900-2021 DIFI Standard. Additionally, the government requires a rough order of magnitude cost estimate covering the bill of materials, installation, and ongoing maintenance. This RFI is for information gathering purposes and does not constitute a formal solicitation or a commitment to a future procurement.
W6QK Acc-Apg

POSTED

about 21 hours ago

DEADLINE

in 30 days
View Details
NAICS: 541715
New
Federal
AIR COMBAT COMMAND HEADQUARTERS (ACC HQ) ACQUISITION MANAGEMENT INTEGRATION CENTER (AMIC) COMMERCIAL SOLUTIONS OPENING (CSO)
Solicitation # FA4890-CSO-0001-24
This solicitation, issued by the Air Combat Command Headquarters Acquisition Management Integration Center (ACC HQ AMIC) under solicitation number FA4890-CSO-0001-24, is a Commercial Solutions Opening (CSO) aimed at attracting innovative commercial technologies and services. The CSO framework follows DFARS 212.70 and seeks proposals that introduce new technological capabilities or enhance existing U.S. Air Force mission effectiveness. It encourages solutions that address capability gaps or offer advancements aligned with ACC’s technology objectives. Submissions may include existing commercial technologies or processes not currently employed by the Air Force but that could improve operational efficiency. The CSO invites a wide range of technical and business proposals, with awards potentially issued under FAR Part 12 or Other Transaction Authority, contingent on the availability of funds and program priorities. The solicitation defines a structured proposal format, including detailed attachments dictating quad charts, white papers, technical proposals, price proposals, and a statement of work (SOW), each with specific length and content requirements. The evaluation factors balance technical merit, relevance to agency priorities, and funding availability, with price assessed only for fairness and reasonableness rather than trade-off decisions. Proposals undergo careful technical and scientific peer review to ensure alignment with ACC goals. The SOW for proposed efforts must clearly outline objectives, milestones, tasks, and deliverables within a ten-page standalone document, following precise formatting standards and excluding proprietary data. Key procedural updates and topic modifications have been made through several amendments extending the open period and revising topic inclusions. Performance is designated for Grassy Creek, Virginia. Although specific contract clauses typical of FAR or DFARS are not included in this CSO, a government-supplied Supplemental Requirements SOW may impose additional binding terms upon award. The contract contemplates flexible award funding, with options for partial or incremental funding, and places the responsibility for inspection and acceptance on the government. Proposal submission is electronic, with stringent requirements for document formatting and identification, including mandatory UEI and CAGE codes but no requirements for socioeconomic status certifications. Contact points and administrative instructions are provided for proposal inquiries, though financial and invoicing details will be specified upon contract award.
FA4890 Hq Acc Amic

POSTED

about 21 hours ago

DEADLINE

in 7 months
View Details
NAICS: 541715
New
Federal
Perrseus
Solicitation # DARPA-PS-26-127
The Defense Advanced Research Projects Agency (DARPA) is seeking innovative proposals under solicitation DARPA-PS-26-127, titled Perrseus, to advance the development of compact cold-atom devices and environmentally-decoupled ultra-high Q microelectromechanical (MEMS) and photonics systems through microscale ultra-high-vacuum (µUHV) technologies. This effort is structured as an Other Transaction (OT) agreement under 10 U.S.C. § 4022, bypassing traditional Federal Acquisition Regulation (FAR) processes to enable faster, more flexible collaboration with nontraditional defense contractors, academia, and small businesses. The award will be milestone-based, with payments tied to the successful completion of technical objectives defined in the performer’s proposal, and may follow a fixed-support or expenditure-based model depending on the negotiated structure. The program includes robust intellectual property provisions, where the government retains certain rights to inventions and data, while performers retain ownership, subject to specific obligations regarding practical application and record retention. Cybersecurity requirements mandate safeguarding covered defense information in accordance with CUI standards and require prompt reporting of cyber incidents, with applicable flow-down provisions to all subcontractors. Performance will be measured through periodic milestone reports reviewed by a DARPA Agreement Officer’s Representative, with electronic submission and acceptance handled via the Wide Area Workflow (WAWF) system. All awardees must be registered in the System for Award Management (SAM), maintain active Cage Code, UEI, and TIN data, and submit required certifications regarding tax compliance, felony convictions, and lobbying activities. A Data Management Plan must be submitted within 30 days of award via the DARPA Vault tool, and final deliverables include an executive summary, property reports for items over $10,000, and compliance with export control and telecommunications prohibitions. Proposals are due by September 23, 2026, and must be submitted via email with a password if necessary, while invention disclosures must be filed through I-Edison. The program emphasizes rapid prototyping, strict information control—prohibiting public dissemination without DARPA approval—and compliance with civil rights and national security mandates, including potential classification requirements if sensitive technologies are developed.
Defense Advanced Research Projects Agcy

POSTED

about 21 hours ago

DEADLINE

in 22 days
View Details
NAICS: 541715
New
International
MINERVA Initiative – Uncrewed Ground System for Surveillance and Reconnaissance
Solicitation # EN578-24ISC4/93
The MINERVA Initiative, sponsored by the Department of National Defence and the Canadian Army, seeks an innovative, domestically produced uncrewed ground system (UGS) for surveillance and reconnaissance. This challenge is specifically open for Phase 2 prototype development for solutions with a technology readiness level between 5 and 9. The goal is to provide soldiers with a durable, easy-to-maintain alternative for persistent surveillance and reconnaissance that can operate in complex battlespaces while minimizing risk to personnel. The required system must include a ground vehicle, sensor payload, ground control station, radio, battery with charger, and a remote antenna. Mandatory technical specifications include an operational temperature range of -20C to +40C, a maximum unladen weight of 410kg, a minimum operational radius of 3km, and the ability to navigate various terrains and gradients. The project offers maximum funding of 500,000 CAD per contract for a duration of up to 15 months, with an estimated five contracts to be awarded. Proposals must be submitted by September 10, 2026.
Department of Public Works and Government Services

POSTED

1 day ago

DEADLINE

in 9 days
View Details
NAICS: 541715
New
International
Light Forces Enhancement
Solicitation # WS5642957262
The Government of Canada, through Public Services and Procurement Canada, is seeking industry input for the Light Forces Enhancement project aimed at providing the Canadian Armed Forces with advanced light tactical vehicles capable of transporting personnel and cargo across challenging terrain previously accessible only on foot. These systems are designed to reduce the physical burden on soldiers by carrying additional equipment and supplies, while significantly expanding operational reach through increased speed, range, and endurance. The solution must be lightweight and robust enough to operate effectively in both domestic and expeditionary environments, including high-threat scenarios, ensuring enhanced mobility and combat effectiveness across diverse military missions. The solicitation, identified as WS5642957262, was posted on July 2, 2026, with responses due by August 31, 2026, at 2:00 p.m. Eastern Time. It falls under NAICS code 541715 and is open to industry partners responding to the Government of Canada’s urgent need for modern, scalable, and survivable light tactical capabilities. The primary point of contact for inquiries is Riccardo Panarella of PSPC, and the place of performance encompasses all locations across Canada where the equipment may be deployed. This initiative follows previous requests for information and is part of a broader effort to modernize Canadian Armed Forces logistics and mobility platforms.
Department of Public Works and Government Services

POSTED

1 day ago

DEADLINE

in about 2 months
View Details
NAICS: 541715
New
Grant
Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Clinical Trial Optional)
Solicitation # PAR-27-053
The National Institutes of Health, under the Department of Health and Human Services, is issuing solicitation PAR-27-053 for Exploratory Clinical Neuroscience Research on Substance Use Disorders. This funding opportunity utilizes a R61/R33 Phased Innovation Award to support clinical research that is exploratory and developmental, specifically focusing on the neurobiological mechanisms, fundamental circuitry, and behavior associated with substance use disorders. The application process is designed for projects requiring a phased research approach, with a response deadline of June 16, 2028. Applicants whose projects do not require this phased structure are encouraged to seek alternative funding activity codes, such as the Research Project Grant Parent R01. Interested parties can contact the National Institutes of Health for further details regarding this federal solicitation.
National Institutes Of Health

POSTED

1 day ago

DEADLINE

in almost 2 years
View Details
NAICS: 541715
New
Grant
Limited Competition for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Clinical Centers (U01 Clinical Trial Required)
Solicitation # RFA-DK-27-125
The National Institutes of Health, under the Department of Health and Human Services, has issued solicitation RFA-DK-27-125 for a limited competition to extend the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) clinical trial consortium. This three-year extension aims to support three clinical centers and one scientific and data research center to achieve enrollment targets, complete participant follow-up, and facilitate the analysis and dissemination of study findings. The initiative seeks to establish a standard of care for patients recovering from Stage 2 and 3 acute kidney injury, as no such standard currently exists. Eligible organizations must submit their applications by November 6, 2026. All submissions will undergo a standard peer-review process, and funding will be awarded only to meritorious applications. The primary goal of the extended study is to provide critical insights that will directly inform improved clinical management strategies for AKI survivors.
National Institutes Of Health

POSTED

1 day ago

DEADLINE

in 2 months
View Details
NAICS: 541715
New
Grant
Limited Competition: NIGMS Mature Synchrotron Resources (MSR) for Structural Biology (P30 - Clinical Trial Not Allowed)
Solicitation # PAR-27-068
The National Institutes of Health, under the Department of Health and Human Services, has issued solicitation PAR-27-068 for Mature Synchrotron Resources for Structural Biology. This limited competition provides funding for established synchrotron facilities that offer X-ray beamline access for the static and dynamic imaging of biological systems. To be eligible, applicants must request support for existing resources that are currently funded by NIGMS and utilize well-established techniques that do not require significant new technology development. Awardees are expected to maintain or upgrade their facilities according to current best practices, provide comprehensive user training and support, and conduct outreach to the biomedical research community. Applications will undergo a standard peer-review process to determine merit. The response deadline for this opportunity is October 2, 2028.
National Institutes Of Health

POSTED

1 day ago

DEADLINE

in about 2 years
View Details