HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)

The National Institutes of Health, under the Helping to End Addiction Long-term Initiative, is soliciting applications for the Integrative Management of chronic Pain and OUD for Whole Recovery research network. This initiative aims to renew the IMPOWR network to test and implement improved healthcare delivery approaches for individuals suffering from both chronic pain and opioid use disorder. The program will support six to eight clinical studies utilizing hybrid implementation-effectiveness designs, coordinated by a central center. Eligible applicants include for-profit organizations and small businesses, with direct costs limited to 900,000 dollars per year over a maximum project period of five years. Awardees must adhere to strict regulatory and operational requirements, including the registration of clinical trials on ClinicalTrials.gov and compliance with the Cybersecurity Act of 2015, which mandates incident reporting within 48 hours. Key personnel, specifically Project Directors and Principal Investigators, must commit at least 2.0 person-months annually and actively participate in network meetings and publications. Applications are evaluated based on significance, study timeline, and protections for human subjects. Required submissions include detailed engagement plans for Evidence-to-Action and OUD and Pain Partners, as well as a comprehensive Data Management and Sharing Plan.