This Solicitation opportunity from Texas was posted on August 5, 2025. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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High-Impact/High-Risk Research Awards

Closed

542-AR_FY26.2_HIHRState & Local

Submission Closed12/02/2025, 12:00:00 AM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541715

New

Federal

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Naval Air Systems Command

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DEADLINE

Digital Biomarker & Computational Modeling DevelopmentThis subcontract focuses on the development and validation of objective digital biomarkers and computational models to support prime contractors within the Defense Health Agency Alzheimer’s Research Program. The scope of work involves utilizing high-performance computing and AI/ML software frameworks to create algorithms for early disease detection and predictive models for disease forecasting. The project requires strict adherence to HIPAA compliance and FDA software validation standards to ensure the integrity and security of the delivered models. Performance will take place in Frederick, Maryland, with the primary objective of delivering validated digital biomarkers and predictive tools to the Department of Defense.

Defense Health Agency

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TBI & Psychological Health Research Services

Defense Health Agency

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Novel Materials Analysis SupportThe Novel Materials Analysis Support subcontract involves providing specialized research and analysis to characterize, detect, and quantify materials of interest for prime contractors supporting Air Force Technical Applications Center projects. The scope of work includes investigating research and development technologies to improve detection methods and utilizing chemical analysis tools and specialized hardware to quantify novel materials. The successful provider will be responsible for delivering detailed analysis reports and quantification data. This effort is managed under the Department of Defense for the agency FA7022 Amic Det 2 Ol Patrick Pka, with performance taking place at Patrick Air Force Base. Due to the sensitive nature of the work, a TS/SCI security clearance is required. The opportunity is categorized under NAICS code 541715, with a response deadline set for November 14, 2026.

FA7022 Amic Det 2 Ol Patrick Pka

POSTED

DEADLINE

Analytical Laboratory R&D (Methods & Technology)The Analytical Laboratory R&D (Methods & Technology) subcontract focuses on the development and testing of new analytical methods and technologies to improve the forensic analysis of field samples for Air Force Technical Applications Center projects. The scope of work involves performing research, development, test, and evaluation to concentrate target compounds from complex matrices, conducting extensive literature searches, and evaluating new analytical instrumentation. These tasks require the use of advanced laboratory tools and forensic instrumentation to deliver finalized analytical protocols and equipment evaluations. This Department of Defense project is managed by the Amic Det 2 Ol Patrick Pka and is performed at Patrick Air Force Base. Due to the nature of the forensic and technical work, a TS/SCI security clearance may be required for personnel. The opportunity is categorized under NAICS code 541715, with a response deadline set for November 14, 2026.

FA7022 Amic Det 2 Ol Patrick Pka

POSTED

DEADLINE

Chemical Process Modeling & Simulation (ChemCAD)This subcontract for the Department of Defense involves the research, development, and maintenance of chemical process models to support prime contractors on Air Force Technical Applications Center projects. The scope of work focuses on developing and updating ChemCAD models, enhancing software for thermodynamics and emission methodology, and conducting RDT&E to determine chemical manufacture constraints. Successful execution requires the use of ChemCAD software and specialized thermodynamic databases, with final deliverables consisting of technical reports and updated software models. The project is managed by the Department of Defense under agency FA7022 Amic Det 2 Ol Patrick Pka and will be performed at Patrick Air Force Base. Due to the sensitive nature of the work, a Top Secret security clearance is mandatory for personnel. Interested parties should note the response deadline of November 14, 2026, and the classification under NAICS code 541715.

FA7022 Amic Det 2 Ol Patrick Pka

POSTED

DEADLINE

Ammonia-Assisted Regeneration for Longer-Lasting Direct Air Capture (DAC)

Solicitation # S-167699

Triad - DOE Contractor

POSTED

DEADLINE

Space Power and Reactor Capabilities (SPARC) - Sources Sought Notice

Solicitation # 80GRC026R0009_PS

NASA Glenn Research Center

POSTED

DEADLINE

Atomically Precise Molecules (APM)

Solicitation # DARPA-PS-26-141

The Atomically Precise Molecules (APM) program, solicitation DARPA-PS-26-141, is a 36-month initiative by the DARPA Multi X Office seeking innovative synthesis techniques for programmable precision polymers (PPPs) and nonlinear optical (NLO) materials. The program aims to develop scalable materials with strictly controlled monomer sequences and compositions, culminating in a prototype NLO material integrated into a government-provided electro-optic modulator capable of achieving greater than 1THz modulation. The effort is structured in two phases, with Phase I lasting 12 months and focusing on synthesis capabilities. Research limited to inorganic materials or incremental improvements to existing state-of-the-art practices is specifically excluded. Awards will be issued as Other Transaction for Prototype Agreements, with payments processed through the Wide Area Workflow system based on a schedule of milestones. Proposals are due by December 18, 2026, via the Broad Agency Announcement Tool and must include technical, management, and pricing volumes. Eligibility is restricted to U.S. organizations, and all performers must comply with CMMC Level 2 self-certification and NIST SP 800-171 standards for safeguarding Controlled Unclassified Information. Evaluation will be based on technical approach, relevance to the DARPA mission, budget realism, and the capability to transition the technology to military or commercial sectors.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Sole Source to L3Harris ForceX, Inc | VAMPIRE Spares

Solicitation # SPRRA2-27-R-SP05

Al DLA Aviation At Huntsville

POSTED

DEADLINE

A-- TREDS III supporting DOE, NNSA and NFO

Solicitation # 89233127RNA000340

Nnsa Non-Mo Cntrctng Operations Division

POSTED

DEADLINE

Request for Proposal (RFP) - Resilient Missile Warning Tracking (RMWT) Low Earth Orbit (LEO) Ground Entry Points (GEPs)

Solicitation # FA240126R0003

The Space Development Agency is soliciting proposals under solicitation FA240126R0003 for the Resilient Missile Warning Tracking Low Earth Orbit Ground Entry Points effort. This acquisition is structured as an Indefinite Delivery Indefinite Quantity contract with a ceiling of 369 million dollars, covering the development, integration, test, operations, and maintenance of Tranche 3 Ground Entry Points at multiple globally dispersed locations. The scope of work encompasses civil engineering from detailed design through construction, the procurement and installation of communications shelters, antennas, optical terminals, and networking equipment, as well as the development of Ground Support Equipment and Auxiliary Development Units. The contract includes an ordering period from March 31, 2027, to September 30, 2031, with option periods extending through September 30, 2035. Award will be determined using a best value tradeoff process where technical, management, and past performance factors are combined and considered significantly more important than price. The technical evaluation focuses on the understanding of requirements, feasibility of approach, and scalability, while management is assessed based on project and schedule management, subcontractor oversight, and security handling. Proposals must be submitted in seven volumes via the DoD Secure Access File Exchange by 4:00 PM Eastern Time on November 23, 2026. Large business primes are required to meet a minimum quantitative requirement of 5 percent small business participation. The contract utilizes a mix of Firm Fixed Price for primary labor and materials and Cost Reimbursable arrangements for other direct costs and travel.

FA2401 Space Development Agency Sda

POSTED

about 22 hours ago

DEADLINE

in 26 days

AI Contract Overview

This contract supports high-impact, high-risk research projects focused on groundbreaking investigations into the causes, diagnosis, treatment, and prevention of cancers. The initiative aims to fund innovative and developmental studies that address promising but still emerging topics, which are not yet ready for traditional funding sources. The awards are designed to lay the groundwork and generate preliminary data necessary for future peer-reviewed grants, thereby fostering pioneering research with the potential for significant contributions to cancer science. The funding range for these awards varies from $500,000 to $5,000,000, with the solicitation posted on August 5, 2025, and a response deadline of December 2, 2025. Managed by Texas Grants under the Texas organization, the program emphasizes supporting projects within the state of Texas. Interested applicants can contact Myriam Casillas via email for further information. The initiative underscores a commitment to advancing innovative cancer research through strategic, high-risk investments that could lead to major scientific breakthroughs.

General Info

Agency

Texas Grants

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

TX, USA

Set-Aside

NONE

Documents

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Timeline

PhaseClosed

PostedAug 5

Solicitation

Response DeadlineDec 2

Deadline has passed

Submission Closed

12/02/2025, 12:00:00 AM UTC

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Organization & Contact Information

AgencyTexas Grants

Contacts1 person available

OfficeN/A

Organization / AgencyTexas Grants

Office AddressN/A

Contacts

Myriam Casillas

contact@example.gov

Full Description

Supports applications that explore the feasibility of high-risk projects that, if successful, would contribute major new insights into the etiology, diagnosis, treatment, or prevention of cancers. Using this mechanism, CPRIT intends to support innovative, developmental projects that focus on exceptionally promising topics that are not yet sufficiently mature to compete successfully for more conventional funding. The HIHR Research Awards are expected to provide the foundation and preliminary data for individual or multiple investigator peer-reviewed awards.