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High-Throughput Functional Genomic Assaying

Active

Grant

Response Deadline12/14/2026, 05:00:00 AM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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This subcontract, titled High-Throughput Functional Genomic Assaying, supports National Institutes of Health and NHGRI research projects by providing experimental testing of genomic variants. The scope of work involves implementing high-throughput assays to perturb variants and executing functional interpretation strategies utilizing CRISPR-based systems and high-throughput screening platforms. The selected provider is responsible for delivering raw molecular and cellular data along with all associated metadata. The project is managed under the Department of Health and Human Services and requires strict adherence to 45 CFR Part 46 regulations regarding human subjects research. The opportunity was posted on October 9, 2026, with a response deadline of December 14, 2026. It is categorized under NAICS code 541714 for research and development in biotechnology.

General Info

Subcontract for high-throughput genomic variant testing and data delivery for NIH research projects.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

This scope was carved out of RFA-HG-27-007.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)

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Timeline

PostedOct 9

subcontract

Response DeadlineDec 14

Submission deadline

Response Deadline

12/14/2026, 05:00:00 AM UTCin 2 months

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health

ContactsNo contacts available

OfficeN/A

Organization / Agency

Department Of Health And Human Services → National Institutes Of Health

Office AddressN/A

ContactsNo contact information available

Full Description

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Performs experimental testing of genomic variants for prime contractors on NIH/NHGRI research projects. Implements high-throughput assays to perturb variants and executes experimental strategies for functional variant interpretation using CRISPR-based systems and high-throughput screening platforms. Requires compliance with 45 CFR Part 46 for human subjects research. Delivers raw molecular and cellular data and associated metadata.

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Cellular Senescence Network (SenNet): SenNet Technology Projects (SenTecs) (UG3/UH3 Clinical Trial Not Allowed)

Solicitation # RFA-RM-27-007

The National Institutes of Health, under the Department of Health and Human Services, is soliciting the development or adaptation of innovative senescence technologies (SenTecs) through solicitation RFA-RM-27-007. These technologies aim to identify, characterize, and understand senescent cell heterogeneity within tissue environments and secretomes to improve strategies for modulating these cells in human aging and disease. The program utilizes a five-year, milestone-driven award structure divided into two phases: a two-year UG3 phase focused on development and feasibility, and a three-year UH3 phase dedicated to optimization, refinement, and validation. Transition to the UH3 phase is not automatic and requires an administrative review at the end of year two. The final year of the award requires a collaborative demonstration project within the SenNet consortium. The NIH intends to commit 5.4 million dollars in total costs for fiscal year 2027 to fund up to nine awards, with direct cost caps of 400,000 dollars per year for the UG3 phase and 550,000 dollars per year for the UH3 phase. Applications are evaluated based on the importance of the research, scientific rigor, feasibility, and the expertise of the investigators. Required submissions include an Intellectual Property Strategy and a Data Management and Sharing Plan. Awardees must adhere to strict cybersecurity incident reporting, maintain a seven-year confidentiality agreement for non-public information, and ensure all technical assets and data are deposited into the SenNet Data Portal. Clinical trials are not allowed under this specific opportunity.

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IGVF Data and Coordinating Center (U24 Clinical trials Not Allowed)

Solicitation # RFA-HG-27-008

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Cellular Senescence Network (SenNet): Discovery, Validation Centers (UM1 Clinical Trials Not Allowed)

Solicitation # RFA-RM-27-016

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POSTED

DEADLINE

in about 1 month

Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)

Solicitation # RFA-HG-27-007

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Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)

Solicitation # RFA-HG-27-009

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Solicitation # RFA-RM-27-016

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POSTED

DEADLINE

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Cellular Senescence Network (SenNet): SenNet Technology Projects (SenTecs) (UG3/UH3 Clinical Trial Not Allowed)

Solicitation # RFA-RM-27-007

The National Institutes of Health is soliciting proposals for the Cellular Senescence Network through solicitation RFA-RM-27-007 to develop or adapt innovative senescence technologies. These technologies aim to identify, characterize, and understand the biological consequences of senescent cell heterogeneity within tissue environments and secretomes. The ultimate goal is to create novel strategies for modulating these cells in vivo and predicting outcomes for human aging and various disease conditions. These five-year, milestone-driven awards are structured in two distinct phases. The initial two-year UG3 phase focuses on technology development and feasibility, while the subsequent three-year UH3 phase is dedicated to optimization, refinement, and validation, concluding with a collaborative demonstration project within SenNet. Applicants must submit both phases together, though transition to the UH3 phase is contingent upon an administrative review following the second year. Responses are due by November 24, 2026.

POSTED

DEADLINE

in about 1 month

IGVF Data and Coordinating Center (U24 Clinical trials Not Allowed)

Solicitation # RFA-HG-27-008

The National Human Genome Research Institute is seeking applications for the Impact of Genomic Variation on Function Data and Coordinating Center under solicitation RFA-HG-27-008. The selected center will act as the primary coordinating hub for the IGVF Consortium, focusing on the development and expansion of accessible resources such as a data portal and a searchable catalog of predicted and measured variant impacts. Key responsibilities include facilitating consortium activities, collaborating with other research programs, and gathering community input to refine the catalog's design to accelerate the understanding of genomic variation. This federal solicitation was posted on October 9, 2026, with a response deadline of December 15, 2026. The opportunity is designated as a U24 grant, and clinical trials are not allowed. The project aims to maximize the overall scientific impact of the IGVF Consortium through strategic coordination and the provision of comprehensive genomic data resources.

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POSTED

DEADLINE

Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)

Solicitation # RFA-HG-27-009

The National Human Genome Research Institute, under the National Institutes of Health, is soliciting applications for solicitation RFA-HG-27-009 to establish interaction centers focused on studying how genetic and environmental interactions influence genomic variant impact. Selected centers are required to develop a research framework to investigate non-additive modifiers, experimentally test variant combinations, and share their findings, data, and predictive methodologies through the Impact of Genomic Variation on Function portal and catalog. This initiative aims to improve the prediction of critical interactions, enhance the understanding of genome-wide association studies, and refine polygenic scores. As members of the IGVF Consortium, participating centers must collaborate to ensure resources remain accessible and coordinate on assays, variants, and cell types to develop unified analysis strategies. Interested parties must submit their applications by the response deadline of December 15, 2026. This federal opportunity emphasizes a combination of original research and resource development to map the interaction landscape of genomic variation.

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POSTED

DEADLINE

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