Human Respiratory Epithelial Tissue Models for Opioid-Reversal Nasal Spray Perme

The Food and Drug Administration is seeking a provider for specialized human-derived nasal and respiratory epithelial tissue models and corresponding culture media. These materials are essential for an FDA-funded project focused on the in vitro characterization of generic drug products used for opioid overdose reversal, specifically testing the permeation of naloxone and nalmefene nasal sprays across physiologically relevant barriers. The acquired tissues will be used to generate biorelevant data to evaluate how different formulations affect drug absorption and to support the development of alternative in vitro approaches for non-Q1/Q2 generic products. Funding for these batch orders of 3D human-derived respiratory epithelial tissue models has been specifically allocated within the project's awarded proposal to facilitate these critical permeation studies.