In Vitro Detection Assay Development

The contract pertains to the development and validation of in vitro assays designed to detect specific base modifications in DNA, utilizing advanced analytical techniques such as mass spectrometry and reporter systems. The work aims to create sensitive, reliable methods for identifying epigenetic or chemical alterations in DNA sequences, with applications likely tied to biological detection, forensic analysis, or bio defense capabilities. The project requires rigorous methodology validation to ensure accuracy, reproducibility, and scalability under controlled laboratory conditions. This subcontract opportunity is issued under the NAICS code 541380 for other scientific research and development services by the Defense Advanced Research Projects Agency within the Department of Defense. The solicitation was posted on May 6, 2026, with a firm response deadline of June 24, 2026, at 4:00 p.m. No set-aside designation or organizational type restrictions are specified, and the place of performance details are not provided, leaving flexibility for the contractor’s location. The absence of a point of contact or office address suggests that all communications and submissions must be handled through the SAM.gov portal linked in the posting.