Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)

DARPA is seeking innovative proposals aimed at developing and demonstrating proof-of-concept technologies for writing and erasing epigenetic base modifications in DNA. These mechanisms are intended to advance the ability to control DNA-protein interactions and enable exploration of rare or novel epigenetic modifications, which could have significant implications for understanding and manipulating nucleic acids. The research is focused on producing novel in vitro methods that effectively modify the epigenome. This special notice, titled "Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)," was posted on May 6, 2026, with a response deadline of June 24, 2026. The solicitation number is DARPA-SN-26-67 and it falls under the NAICS code 541714. The effort is coordinated by the Department of Defense through the Defense Advanced Research Projects Agency, specifically the Biological Technologies Office located in Arlington, Virginia. Interested parties can contact Dr. Aric Lu at DARPA via email for further information. The opportunity emphasizes cutting-edge bioengineering challenges with potential broad impacts on epigenetics and molecular biology tools.