Limited Competition: The NHGRI Analysis, Visualization, and Informatics Lab-space (AnVIL) (U54 Clinical Trial Not Allowed)
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The National Human Genome Research Institute (NHGRI) plans to issue a Notice of Funding Opportunity (NOFO) for a limited competition renewal of the Analysis, Visualization, and Informatics Lab-space (AnVIL) program, a cloud-based platform designed to facilitate secure access, sharing, and analysis of large-scale genomic data without local infrastructure. AnVIL currently supports over 5 petabytes of data from nearly 300,000 research participants, enabling reproducible and cloud-native genomic research. The renewed program will build on this foundation by enhancing scalability, interoperability within the NIH data ecosystem, and maintaining stringent security standards in line with NIH's Research Authentication Service and controlled-access data repository requirements. Additionally, the program will integrate emerging data types and computational tools, including AI-based methods and complex workflows. Beyond platform development, the renewal will emphasize expanding training and outreach efforts to enable researchers to effectively utilize AnVIL's multimodal datasets and analysis capabilities. By linking secure data access, advanced analytical tools, and workforce development, it aims to accelerate discoveries across the research lifecycle and strengthen genomics research capacity for clinical and translational science. The NOFO is expected to be released in 2027 with applications due the same year and will be funded under the U54 activity code. Eligible organizations will be invited to apply through a peer-reviewed process, ensuring only meritorious proposals receive funding. For inquiries, applicants can contact the Office of the Director / Office of Genomic Data Science at the NHGRI.
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The National Human Genome Research Institute (NHGRI) intends to issue a Notice of Funding Opportunity (NOFO) to support a limited competition renewal of the Analysis, Visualization, and Informatics Lab-space (AnVIL) program. AnVIL is a secure, cloud-based platform that enables researchers to access, share, and analyze large-scale genomic datasets without relying on local infrastructure. Currently, AnVIL hosts more than 5 petabytes of data from nearly 300,000 research participants, providing a robust environment for reproducible, cloud-native genomic research.
The renewed program will continue to advance AnVIL as a community resource grounded in FAIR (Findable, Accessible, Interoperable, and Reusable) principles. Key priorities include enhancing scalability; strengthening interoperability across a federated NIH data ecosystem; and maintaining rigorous security aligned with the Research Authentication Service (RAS) and NIH controlled-access data repositories and access management systems (CADR) requirements (see NOT‑OD‑25‑159). The renewal will also support integration of emerging data types and computational tools, including infrastructure for developing and running AI-based methods and complex analysis workflows.
In addition to platform development, the program will expand training and outreach to help researchers effectively use AnVIL’s multimodal datasets and reproducible analysis capabilities. By connecting secure data access, analytical tools, and workforce development, the renewed AnVIL program aims to accelerate discovery across the research lifecycle and strengthen the genomics community’s capacity for clinical and translational science.
This Notice is being provided to allow potential applicants sufficient time to develop responsive applications. The NOFO is expected to be published in 2027 with an anticipated application due date in 2027. This NOFO will utilize the U54 activity code.
This is a Forecast for a limited competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.