Mathematical model development based on a set of ordinary deferential equations (ODE) for the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on cardiovascular and thermoregulatory response to the heat stroke in vivo model.

Under the authority of FAR 13.5, the U.S. Army RDECOM Contracting Center, Natick Contracting Division, Natick, MA intends to award a Firm Fixed Price Purchase Order to University of California, Santa Barbara, to Develop a mathematical model based on a set of ordinary deferential equations (ODE) for the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on cardiovascular and thermoregulatory response to the heat stroke in vivo model, to Predict the efficacy of NSAIDs and identify optimal therapeutic windows for heat stroke recovery by applying Model Predictive Control (MPC) to the developed model, to Develop gene-/protein-level biophysical network models and analyze protein level data for identification of mechanisms of long-term heat injury progression, to Identify targets of intervention for optimal heat stress recovery using a systems approach to relate gene-/protein-level biophysical network models with animal-scale model, to Identify biomarkers that predict outcome by system identification tools and by artificial intelligence. Apply MPC to calculate precise intervals of optimal target interventions to recover heat stress based on systems biology level model, and to Prepare final technical report and/or manuscript(s). Recent work by Leon et al. (J. Appl. Physiol. 100: 1400-1409, 2006) has established the long-term thermoregulatory, tissue injury and protein responses during heat stroke recovery in mice. University of California Santa Barbara /Dr. Doyles work in the area of optimized circadian resetting (Bagheri et al., 2008) has established modeling capabilities that support the prediction of intervention strategies for physiological reset. A working relationship has been established in so much that both investigators are up to speed on current work from both parties and they have previously collaborated on a project which was the basis for this current project. Thus, this collaborative project will support the development of a systems biology initiative to mitigate heat injury in the Warfighter and develop predictive models related to determine the efficacy of pharmacological agents for the treatment of heat injury/ return to duty and determine how responses may differ in rodent populations that simulate physiological characteristics of special forces populations. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement in the future. Interested parties may identify their interest and capability to respond to this requirement to the U.S. Army RDECOM Contracting Center, Natick Contracting Division, via e-mail at contact@example.gov. no later than 4 April 2009, 12:00 pm EST.