Molecular Engineering for Neural Modulation

The contract seeks to design and develop advanced molecular tools, including engineered proteins and synthetic gene circuits, capable of precisely modulating neural plasticity within targeted brain circuits while avoiding unintended effects on surrounding tissue. The work must enable selective control over synaptic strengthening, weakening, or remodeling mechanisms, leveraging cutting-edge bioengineering approaches to achieve high specificity and minimal off-target activity. This effort is part of a broader initiative to enhance neurotechnological capabilities for defense and biomedical applications, requiring innovative solutions that integrate molecular biology with neuroscience. The project falls under NAICS code 541715 for research and development in the physical, engineering, and life sciences and is issued as a subcontract by the Defense Advanced Research Projects Agency under the Department of Defense. Proposals must be submitted by August 14, 2026, with the solicitation posted on August 6, 2026. The performance location is not specified, and no set-aside provisions apply. The contract aims to push the boundaries of precision neural control through molecular innovation, with outcomes expected to support next-generation neurointerfaces, therapeutic interventions, and cognitive enhancement technologies for national security and medical use.