Multiorgan Microphysiological System (MPS) Platform Development

The contract seeks the design and engineering of a sophisticated human multiorgan microphysiological system, commonly referred to as an organ-on-a-chip, capable of simulating complex radiation injury responses under recirculating fluidic conditions. This platform will integrate multiple organ modules with precise fluidic control systems to replicate physiological interactions between human tissues, enabling high-fidelity modeling of systemic effects following radiation exposure. The system must support continuous recirculation of biological fluids across organ units to mimic in vivo circulatory dynamics, with emphasis on reproducibility, scalability, and compatibility with advanced analytical instrumentation for real-time monitoring of biological endpoints. The project is classified under NAICS code 334510, indicating its focus on laboratory and analytical instrument manufacturing, and is issued as a subcontract by the NASA Shared Services Center on behalf of the National Aeronautics and Space Administration. Performance is required in Houston, Texas, with a response deadline of July 6, 2026. The initiative aims to advance space biomedical research by providing a preclinical platform to assess radiation risks to astronauts during long-duration missions, supporting NASA’s mission to ensure crew health beyond low Earth orbit. The development must align with stringent technical benchmarks for organ crosstalk, flow dynamics, and radiation dose response accuracy, setting a new standard for in vitro human tissue modeling in space medicine.