This Pre-Solicitation opportunity from Department Of Health And Human Services was posted on July 28, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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NIDDK in vivo efficacy of Fc-bispecifics study

Closed

75N98026Q00898TACONICBIOSCIENCESINCFederal

Submission Closed08/06/2026, 01:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 112990

New

Federal

Detection Canine SupplierThis small business set-aside subcontract, managed by the Department of Homeland Security's Mission Support Contracting Division, involves the sourcing and delivery of single-purpose detection canines for prime contractors working on Customs and Border Protection projects. The supplier is responsible for selecting animals that meet specific suitability criteria for detection training and ensuring all transport systems comply with strict safety, health, and animal welfare regulations. The final delivery of these live detection canines is to be made to the U.S. Border Patrol Canine Academy, with the place of performance located at Fort Bliss. Interested parties must adhere to the response deadline of November 4, 2026, for this opportunity categorized under NAICS code 112990.

Mission Support Contracting Division

POSTED

DEADLINE

Border Patrol Untrained Canine – Detection BPK9 – El Paso, TX.

Solicitation # 20161894

The Department of Homeland Security, U.S. Customs and Border Protection, is seeking quotes for the procurement of 15 untrained detection canines to support the Office of Training and Development. This is a 100% small business set-aside under NAICS code 112990, and the government intends to award a single firm-fixed-price purchase order. The canines must be delivered to the U.S. Border Patrol Canine Academy in El Paso, Texas, and must meet specific breed requirements, including German Shepherd, Dutch Shepherd, Belgian Malinois, Tervuren, or other approved working breeds. Eligible canines must be between 10 and 36 months of age and pass rigorous medical, physical, and behavioral evaluations, including testing for zoonotic diseases. The evaluation process follows a three-phase approach. Phase I is a pass/fail assessment based on breed conformance and an availability date within 60 days of the purchase order. Phase II utilizes a trade-off method considering open order status, past performance with CBP, and price. The top-ranked offeror from Phase II proceeds to Phase III, which involves a physical inspection and evaluation of the canines. The contractor is responsible for all transportation costs and must retrieve any canines that fail evaluation within seven working days. Payment will be processed electronically through the Invoice Processing Platform. Quotes must be submitted via email to the designated contract specialist by November 4, 2026.

Mission Support Contracting Division

POSTED

DEADLINE

Border Patrol Request for Quote (RFQ) for Patrol (Dual Purpose) Canines

Solicitation # 20161895

The Department of Homeland Security, U.S. Customs and Border Protection (CBP), is seeking quotes for three dual-purpose patrol canines to support the Office of Training and Development. The canines will be delivered to the U.S. Border Patrol Canine Academy in El Paso, Texas, and must be capable of searching for, detaining, and apprehending non-compliant subjects. This procurement is a 100% small business set-aside under NAICS code 112990, and the government intends to award a firm-fixed-price purchase order based on a best-value tradeoff between price and non-price factors. The evaluation process consists of three phases. Phase I is a pass/fail screening for breed conformance and an availability date of 60 days or less. Phase II ranks eligible offerors based on their open order status with CBP, past performance over the last three years, and price. The top-ranked offeror proceeds to Phase III, which involves a physical, medical, and behavioral evaluation of the canines. Accepted canines must be between 10 and 36 months old, meet specific breed standards, and be in excellent health with a body condition score of 3-7. The contractor is responsible for all transportation costs and must submit hip and elbow radiographs 14 business days prior to presentation. Payments will be processed electronically through the Invoice Processing Platform.

Mission Support Contracting Division

POSTED

DEADLINE

Border Patrol Untrained Canine – Detection BPK9 – El Paso, TX.

Solicitation # 20151893

The Department of Homeland Security, U.S. Customs and Border Protection (CBP), is seeking quotes for 15 untrained detection canines to support the Office of Training and Development at the Border Patrol K9 Center in El Paso, Texas. This procurement is a 100 percent small business set-aside under NAICS code 112990 and will result in a firm-fixed-price purchase order. The government may procure additional canines beyond the initial quantity based on the availability of funds. All payment requests must be processed electronically through the Invoice Processing Platform. Eligible canines must be German Shepherds, Dutch Shepherds, Belgian Malinois, Tervurens, or other approved working breeds, aged between 10 and 36 months. Technical requirements include specific genetic drives for hunt, air scent, prey, retrieve, activity, and trainability, as well as a lack of fear in high-stress environments. Physical standards require a body condition score of 3 to 7 and a healthy body fat percentage between 16 and 25 percent. The evaluation process follows a three-phase approach. Phase I is a pass/fail screening for breed conformance and an availability date within 60 days of the purchase order. Phase II utilizes a tradeoff method considering open order status, past performance with CBP, and price. Phase III involves a physical, medical, and behavioral evaluation of the canines at the El Paso facility. The contractor is responsible for all transportation costs; canines that fail inspection must be retrieved within seven days at the contractor's expense. Quotes must be submitted via email to the designated contract specialist by November 4, 2026.

Mission Support Contracting Division

POSTED

DEADLINE

Provision of Fully Trained Patrol and Detector CaninesThis subcontract, issued by the Department of Defense under agency FA8053 773 Ess Pkj Mscc, involves the sourcing, training, and delivery of fully trained working dogs for prime contractors operating on Department of War facility projects. The scope of work includes selecting specific breeds that meet strict height and weight requirements and providing specialized training for single and dual purpose detector dogs. These canines must be proficient in patrol duties as well as the detection of explosives and narcotics. The training regimen specifically emphasizes behavioral stability under gunfire and controlled aggression toward decoys. The contractor is responsible for ensuring that all delivered dogs are fully evaluated and accepted based on these rigorous standards. Interested parties should note the response deadline of November 2, 2026, for this opportunity categorized under NAICS code 112990.

FA8053 773 Ess Pkj Mscc

POSTED

DEADLINE

Supply of Single-Purpose and Special Purpose Detector DogsThis subcontract involves the supply of fully trained single-purpose and Special Purpose Detector Dogs for prime contractors supporting Department of War and TSA contracts. The scope focuses on providing canines trained for specific substance detection without patrol requirements, with training tailored to specific courses as defined by individual BPA calls. All delivered dogs must be medically cleared and are subject to a four-phase evaluation process conducted at JBSA-Lackland. The agreement includes a 120-day warranty covering both medical and behavioral defects to ensure the quality and reliability of the animals. Managed under NAICS code 112990 and associated with the Department of Defense, the contract establishes strict standards for the delivery and certification of specialized detection canines.

FA8053 773 Ess Pkj Mscc

POSTED

DEADLINE

Supply of Dual-Purpose (Detector/Patrol) Working DogsThis subcontract involves the supply of fully trained dual-purpose working dogs for prime contractors operating on Department of War facility projects. The scope of work includes sourcing and training canines for both patrol and substance detection under DoW I and DoW II classifications. To ensure operational readiness, the provider must conduct stability testing under gunfire, boldness assessments, and aggression evaluations using decoys. All canines must be presented at JBSA-Lackland for a rigorous four-phase evaluation process to ensure they meet government standards. Upon delivery of the accepted dogs, the provider is required to furnish a 120-day warranty covering any latent behavioral or medical defects. This requirement is managed under NAICS code 112990 for the Department of Defense.

FA8053 773 Ess Pkj Mscc

POSTED

DEADLINE

Purchase Military Working Dogs (OCONUS)

Solicitation # FA890327QX002

The 772nd Enterprise Sourcing Squadron at Joint Base San Antonio is conducting market research via a Sources Sought synopsis to identify qualified providers under NAICS 112990 for the procurement of fully trained Military Working Dogs (MWD) and Government Working Dogs (GWD). The requirement focuses on dogs trained for patrol, explosive detection, and drug detection to support the Department of Defense and the Transportation Security Administration. The intended contract structure is a multiple award Blanket Purchase Agreement (BPA) with a five-year period of performance, where individual dogs are acquired through BPA calls. To be selected for purchase, candidates must pass a rigorous four-phase evaluation process consisting of general requirements, medical screenings, behavioral evaluations, and performance testing. Medical screenings include physical exams and radiographs of the hips, elbows, and lumbar spine, while performance evaluations vary by classification, such as DoW I, DoW II, or TSA Detector Dogs. Evaluations may take place at approved contractor sites or government-controlled locations. The government reserves the right to down-classify dogs that fail higher-level evaluations or direct humane euthanasia in cases of severe safety hazards or intractable suffering. Interested sources must submit their company information, SAM Unique ID, Cage Code, and business size, along with specific lead times for presenting twenty trained dog candidates, by November 2, 2026. This current notice is for information gathering only and does not constitute a formal solicitation; a separate solicitation announcement will be published on SAM.gov at a later date.

FA8053 773 Ess Pkj Mscc

POSTED

DEADLINE

Purchase of Military Work Dog (CONUS)

Solicitation # FA890327QX001

The 772nd Enterprise Sourcing Squadron is conducting a sources sought synopsis under solicitation FA890327QX001 to identify qualified providers for a Department of Defense-wide requirement for fully trained patrol dogs specializing in explosive and drug detection. This initiative aims to support the 341st Training Squadron and the Department of War and Transportation Security Administration. The intended acquisition vehicle is a multiple award Blanket Purchase Agreement with a five-year period of performance. Interested sources must be classified under NAICS code 112990 and provide details regarding their business size, socioeconomic status, inventory capacity, and ability to transport canines to Joint Base San Antonio Lackland, Texas, for evaluation. To be selected for purchase, dogs must pass a rigorous four-phase evaluation process consisting of general requirements, medical screening, behavioral assessments, and performance evaluations. Dogs must demonstrate boldness and fearlessness and are subject to a 120-day medical and behavioral warranty post-delivery. The government utilizes a retain or reject rating scale, though dogs failing higher-level evaluations may be considered for lower classifications through price negotiation. Responses to this sources sought notice are due by November 2, 2026, and will be used to inform a future formal solicitation to be published on SAM.gov.

FA8053 773 Ess Pkj Mscc

POSTED

DEADLINE

Solicitation # 2027-0140

The City of El Paso is soliciting bids under solicitation number 2027-0140 for the procurement of live feeder crickets to support the Zoo Department. The requirement covers six specific cricket sizes, including pinhead, x-small, small-medium, medium, and medium-large, with varying quantities per box. A single award will be made for all items, and bidders must provide pricing for every item to be considered responsive. The contract is expected to exceed 25,000 dollars and includes an option for the City to extend the term for two additional years at the same unit pricing. The solicitation was released on October 19, 2026, with a question deadline of October 26, 2026, and a final bid due date of November 6, 2026. To be compliant, submissions must include a completed bid form, a W-9, a bid submittal and signature page, and several critical affidavits, including Non-Collusion and Business Disclosure, Indebtedness, and Subcontractor/Supplier Identification forms. Bidders must also certify they are not debarred from government transactions, do not boycott energy companies, and do not discriminate against firearm entities. All paper submissions require original signatures to avoid being deemed non-responsive.

POSTED

DEADLINE

RAAF Base Wagga - Yuruga Grazing Licence - 01 Dec 2026 to 31 Jan 2029

Solicitation # EOI/WAGGA/Grazing

The Department of Defence is seeking expressions of interest from experienced parties to enter into a grazing licence for the Yuruga property located within RAAF Base Wagga, New South Wales. The primary objective of this managed grazing arrangement is to enhance land management by reducing bushfire hazards and fuel loads, specifically targeting grasses, while simultaneously controlling weeds and reducing weed seed banks. This initiative aims to decrease the necessity for the Department of Defence to conduct independent land and hazard mitigation activities. The proposed licence period is scheduled to run from December 1, 2026, to January 31, 2029. Interested parties must submit their responses by the deadline of November 16, 2026. This pre-solicitation process is managed by the Department of Defence - DSRG, with inquiries directed to the Estate Property Officer.

Department of Defence - DSRG

POSTED

DEADLINE

Genotyping ArraysThe Agricultural Research Service within the Department of Agriculture is forecasting a requirement for genotyping arrays to support genetic improvement research for channel catfish. This project focuses on utilizing molecular tools to enhance the genotyping process, with the place of performance located in Stoneville. The opportunity is categorized under NAICS code 112990 and was posted on June 17, 2026. Nicole McKenzie serves as both the primary point of contact and the small business specialist for this procurement action.

Agricultural Research Service

POSTED

4 months ago

DEADLINE

N/A

AI Contract Overview

The National Institute of Diabetes and Digestive and Kidney Diseases within the National Institutes of Health is seeking to advance its long-term research into novel antibody-protein conjugates designed to provide durable protection against HIV infection. This effort, funded by the Office of AIDS Research, focuses on evaluating the in vivo antiviral and immune-recruiting activity of a specific panel of conjugates known as APCs, which have previously demonstrated promising results in preventing HIV infection in cell-based and animal models. The current study will expand on a pilot investigation using humanized CD34+ mice, testing six groups of six mice each to assess five different APC formulations alongside a vehicle control. The research will measure viral load through PCR and flow cytometry of T-cells, with blood samples collected at designated timepoints leading to a terminal collection on day 56, followed by serum preparation and analytical processing to determine efficacy in both prophylactic and therapeutic settings. The work is based on earlier findings that highlighted the plasma stability and favorable pharmacokinetic profile of a glycosylated Fc-containing conjugate, mGRFT-Fc(glyc), which triggered strong immune and cytotoxic antiviral responses. This new phase aims to validate and build upon those results by conducting comprehensive in vivo efficacy assessments under controlled conditions at the Laboratory of Bioorganic Chemistry’s Natural Products Chemistry Section in Bethesda, Maryland. The solicitation, issued under the number 75N98026Q00898TACONICBIOSCIENCESINC, is a presolicitation notice with a response deadline in August 2026, and is open to entities capable of supporting complex preclinical research involving animal models, immunological assays, and advanced molecular diagnostics. The project is part of a broader, sustained initiative to develop next-generation biologics for HIV prevention and immune modulation, with all testing and analysis to be conducted in alignment with NIH’s intramural research mission and regulatory standards.

General Info

NIH seeks to evaluate five HIV-targeting antibody-protein conjugates in humanized mice for prophylactic and therapeutic efficacy.

Agency

Department Of Health And Human Services → National Institutes Of Health Olao

NAICS

112990 - All Other Animal Production

Place of Performance

Bethesda, MD, 20892, USA

Set-Aside

NONE

Documents

Notice of Intent Taconic Biosciences

special-notice

Low

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseClosed

PostedJul 28

Presolicitation

Response DeadlineAug 6

Deadline has passed

Submission Closed

08/06/2026, 01:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

Contacts1 person available

OfficeBETHESDA, MD, 20892, USA

Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

Office AddressBETHESDA, MD, 20892, USA

Contacts

Vishnuvajjala Hanumanth Rao

contact@example.gov

Full Description

As part of the statutorily required functions of the National Institute of Health (NIH), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) conducts and supports a wide range of biomedical research directly through intramural research within NIH laboratories, and externally through grants to universities and other medical research institutions across the country. In addition, NIDDK supports research training for students and scientists at various stages of their careers and a range of education and outreach programs to bring science-based information to patients and their families, health care professionals, and the public.

Within the Laboratory of Bioorganic Chemistry, NIDDK, the Natural Products Chemistry Section (NPCS) requires studies to determine the in vivo anti- human immunodeficiency virus (HIV) and immune-recruiting activity of a novel panel of antibody or Fc-lectin/nanobody conjugates (termed antibody-protein conjugates or APC’s). These studies are being performed with optimized APCs that have been shown to prevent HIV infection in cell-based and vivo studies. The research study is needed to expand a recent pilot study in humanized CD34+ mice (strain NOD- Prkdcem26Cd52Il2rgem26Cd22 /NjuCrl). The protocols used will measure antiviral efficacy of the APCs in both pre-infection and post-infection studies. Viral infection will be measured by polymerase chain reaction (PCR) and flow cytometry of T-cells in infected and control mice. In-life blood collections will be conducted on study dates every 2 weeks (W#): -1 day (W0), W2, W4, S6 and W8 (end-point) or +1 day (W0), W2, W4, S6 and W8 (end-point). A terminal blood collection will be conducted on day 56 for all mice. Blood processing and serum preparations will be conducted on all samples. Additionally, PCR and flow cytometry will be conducted. A total of six study groups comprising six CD34+ mice per group will be used for testing of five APCs plus vehicle control.

The NPCS carries out research aimed at developing antiviral antibody-protein conjugates with an emphasis on anti-HIV conjugates that offer durable protection. This is a long-term project that has been funded by the Office of AIDS Research. Previous studies tested plasma stability and toxicity (pharmacokinetics) of conjugate mGRFT-Fc(glyc). Favorable results showing protection and recruitment of immune/cytotoxic antiviral responses in APCs containing a glycosylated Fc region indicate the need for expanded testing.