OpenEye Software Annual Licenses

This contract requires the procurement of an annual subscription to the OpenEye Non-Profit Software Package, which includes a suite of computational chemistry and cheminformatics tools essential for ongoing translational science and drug discovery efforts at the National Center for Advancing Translational Sciences. The software suite encompasses BROOD, EON, FILTER, OEChem TK, OEDocking, OMEGA, OMEGA DB, pKa Prospector, QUACPAC, ROCS, SITEHOPPER, SPRUCE, SZMAP, SZYBKI, and VIDA, supporting molecular modeling, virtual screening, structure-activity relationship analysis, conformer generation, molecular docking, lead optimization, and qHTS data mining. The requirement mandates the immediate reinstatement of the existing OpenEye software environment currently in use by NCATS researchers to ensure continuity of scientific operations without disruption, including full compatibility with internally developed tools and workflows. Additional deliverables include FastROCS and Shape Annual Evaluations, and all software must be licensed under a non-profit agreement with ongoing vendor support, updates, and maintenance provided for the duration of the subscription. The contract is issued as a Request for Quote under solicitation number 75N98026Q00472 by the Department of Health and Human Services through the Omas Strategic Buying Center - Information Technology, with an estimated performance period running from June 15, 2026, to June 14, 2027, commencing within 30 days of award. The place of performance is in Rockville, Maryland, with payment to be made monthly in arrears via the Department of Treasury Invoice Processing Platform upon approval by the Contracting Officer's Representative. The solicitation follows a Lowest Priced Technically Acceptable evaluation methodology, where technical acceptability is a pass/fail gate requiring exact submission of all specified OpenEye tools and evaluations. All offerors must be registered in SAM, provide a unique entity identifier and CAGE code, complete required representations including small business status and compliance with Buy American provisions, and affirm they are not debarred or suspended. The contract incorporates numerous FAR clauses related to ethics, whistleblower protections, labor standards, trafficking in persons, equal opportunity, and accelerated payments to small business subcontractors, with mandatory flow-down of key clauses to any subcontracts. Invoices must comply with FAR 32.905(b) and HHSAR 352.232-71, and all communications must be