This Solicitation opportunity from Department Of Defense was posted on August 7, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Protein ENGineering (PENG)

Closed

DARPA-PS-26-129Federal

Submission Closed10/19/2026, 12:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541714

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Ofc Of Acquisition Grants-Denver

POSTED

7 days ago

DEADLINE

in 8 days

AI Contract Overview

The Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office is soliciting proposals for the Protein ENGineering (PENG) program under solicitation DARPA-PS-26-129. The program aims to develop a multifunctional, target-agnostic platform for the precise and programmable editing of endogenous proteins, transitioning proteome engineering into a software-defined discipline. This integrated platform will utilize modular targeting, generalizable effector chemistries, and multiplexed control systems to modify proteins within complex biological architectures without permanent genomic changes. The effort is structured into three phases over a 42-month period: Phase 1A focuses on foundational biochemistry and generalizability across three protein families; Phase 1B involves executing edits on unannounced targets in complex tissue systems; and Phase 2 focuses on optimization and validation in higher-order biological systems such as organoids. Awards will be issued as Other Transaction Agreements for Prototype, with a two-stage selection process requiring an initial abstract submission followed by an invitation for a full proposal. Abstracts are evaluated based on technical rationale, risk mitigation, and the team's capability to meet aggressive timelines. Successful performers must adhere to strict cybersecurity and data protection standards for Controlled Unclassified Information and utilize the Wide Area Workflow system for milestone-based invoicing and payments. While total contract values are not specified, maximum funding ceilings are provided for specific talent awards, including the Fundamental Defense Research Talent Award and Industry Immersion Program. All submissions must follow mandatory templates and formatting guidelines, with the final goal of delivering a fully integrated editing prototype platform.

General Info

DARPA seeks proposals for a programmable, target-agnostic endogenous protein editing platform prototype.

Agency

Department Of Defense → Defense Advanced Research Projects Agcy

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Set-Aside

NONE

Documents

Attachment H Task Description Document

sow

High

DARPA-PS-26-129 PENG Proposal Summary Slide Template

proposal-summary

High

DARPA-PS-26-129 Protein Engineering Abstract Instructions and Template

abstract-instructions-template

High

DARPA-PS-26-129 Protein Engineering Cost Proposal Instructions and Volume II Template

cost-proposal-instructions

High

DARPA-PS-26-129 Protein Engineering Program Solicitation

High

DARPA-PS-26-129 Protein Engineering Proposal Instructions and Volume I Template

proposal-instructions

High

Other Transaction Agreement for Prototype Development HR0011-XX-9-XXXX

other-transaction-agreement

High

Schedule of Milestones and Payments Attachment I

schedule-of-milestones

High

DARPA Cost Proposal Spreadsheet

cost-proposal-spreadsheet

Low

DARPA-PS-26-129 Protein Engineering Abstract Summary

other

Low

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseClosed

PostedAug 7

Solicitation

Response DeadlineOct 19

Deadline has passed

Submission Closed

10/19/2026, 12:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

Contacts1 person available

OfficeARLINGTON, VA, 222032114, USA

Organization / AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

Office AddressARLINGTON, VA, 222032114, USA

Contacts

BAA Coordinator

contact@example.gov

Full Description

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline.

The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.