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Radiation Oncology-Biology Integration Network (ROBIN) Centers (U54 Clinical Trial Required)

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The National Cancer Institute is seeking applications from new and renewing investigators to support the Radiation Oncology-Biology Integration Network (ROBIN). This initiative establishes a collaborative national research infrastructure dedicated to translational research on the biological responses of tumors and normal tissues during radiation therapy. By utilizing multidisciplinary longitudinal studies to collect biospecimens and multimodal data, the network aims to identify mechanisms of resistance and toxicity, discover new therapy-induced targets, and optimize treatment strategies throughout the course of cancer care. Managed by the National Institutes of Health under the Department of Health and Human Services, this forecast for U54 clinical trial centers emphasizes the integration of expertise in omics, data science, imaging, and clinical oncology. The primary goal is to generate foundational knowledge that enables the combination of radiation with other therapies and accelerates discoveries that inform future clinical trials to improve patient outcomes.

General Info

Support for ROBIN network enabling multidisciplinary radiation oncology research and improved cancer treatment outcomes.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

0

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
NCI ROBIN RFA
contact@example.gov

Full Description

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Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to continue to support the Radiation Oncology-Biology Integration Network (ROBIN) with applications from both new and renewing investigators. This network model will sustain an agile and effective national radiation oncology infrastructure that collectively addresses critical hypothesis-based translational research on the biological basis of responses in cancer patients who undergo radiation treatments. ROBIN supports a collaborative national research network focused on understanding how tumors and normal tissues change biologically during radiation therapy. Because radiation can dynamically alter molecular targets over the course of treatment, the network seeks to generate foundational knowledge that can improve radiation-based cancer care and identify new opportunities for combining radiation with drugs and other therapies. Through multidisciplinary, longitudinal studies, ROBIN centers collect and analyze biospecimens and multimodal data before, during, and after standard-of-care radiation therapy. This work is designed to reveal mechanisms of response, resistance, and toxicity; identify new therapy-induced targets; and determine whether treatment strategies based on initial tumor profiling remain optimal as therapy progresses. The network also strengthens the radiation oncology workforce by integrating expertise in biology, clinical oncology, imaging, dosimetry, omics, biospecimen science, and data science. By sustaining this research infrastructure, NIH aims to accelerate translational discoveries that can inform future clinical trials and improve outcomes for people with cancer.

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