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Radiation Oncology-Biology Integration Network (ROBIN) Centers (U54 Clinical Trial Required)

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Grant

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The contract aims to continue supporting the Radiation Oncology-Biology Integration Network (ROBIN), fostering a collaborative national research infrastructure focused on the biological changes in tumors and normal tissues during radiation therapy. This initiative targets both new and renewing investigators to engage in multidisciplinary, longitudinal studies that collect and analyze biospecimens and diverse data throughout the course of standard radiation treatments. The goal is to deepen the understanding of mechanisms behind treatment response, resistance, and toxicity, while identifying novel therapeutic targets and assessing the evolving effectiveness of treatment strategies as therapies progress. By integrating expertise across biology, clinical oncology, imaging, dosimetry, omics, biospecimen science, and data science, the network strengthens the radiation oncology workforce and accelerates translational research discoveries. These efforts are intended to inform future clinical trials and enhance radiation-based cancer care by uncovering how radiation alters molecular targets over time and identifying new opportunities to combine radiation with other therapies. Funded by the National Cancer Institute under the Department of Health and Human Services, the program requires clinical trials and emphasizes sustaining an agile, effective infrastructure to improve outcomes for cancer patients nationwide.

General Info

Support for ROBIN network enabling multidisciplinary radiation oncology research and improved cancer treatment outcomes.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUS
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
Office AddressUS
Contacts
NCI ROBIN RFA
contact@example.gov

Full Description

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Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to continue to support the Radiation Oncology-Biology Integration Network (ROBIN) with applications from both new and renewing investigators. This network model will sustain an agile and effective national radiation oncology infrastructure that collectively addresses critical hypothesis-based translational research on the biological basis of responses in cancer patients who undergo radiation treatments. ROBIN supports a collaborative national research network focused on understanding how tumors and normal tissues change biologically during radiation therapy. Because radiation can dynamically alter molecular targets over the course of treatment, the network seeks to generate foundational knowledge that can improve radiation-based cancer care and identify new opportunities for combining radiation with drugs and other therapies. Through multidisciplinary, longitudinal studies, ROBIN centers collect and analyze biospecimens and multimodal data before, during, and after standard-of-care radiation therapy. This work is designed to reveal mechanisms of response, resistance, and toxicity; identify new therapy-induced targets; and determine whether treatment strategies based on initial tumor profiling remain optimal as therapy progresses. The network also strengthens the radiation oncology workforce by integrating expertise in biology, clinical oncology, imaging, dosimetry, omics, biospecimen science, and data science. By sustaining this research infrastructure, NIH aims to accelerate translational discoveries that can inform future clinical trials and improve outcomes for people with cancer.

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