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Screen the A10 antibody for off-target binding to plasma membrane proteins and secreted proteins

Awarded
75N91026P00004Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

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The National Cancer Institute has awarded a firm fixed price purchase order to Charles River Discovery Research Services UK Limited to conduct an off-target binding screen for the A10 antibody. This antibody is designed to target cancer cells with high levels of epidermal growth factor receptor, and the primary objective of this contract is to identify any unintended interactions with other plasma membrane or secreted proteins that could lead to serious side effects in patients. Managed by the Department of Health and Human Services through the Program Support Center Acquisition Management Services, the project will be performed in Saffron, Essex. The contract, identified by solicitation number 75N91026P00004, focuses on ensuring the safety and specificity of the A10 antibody before further clinical application.

General Info

Agency

Department Of Health And Human Services → Program Support Center Acq Management Svc

Contract Value

$38,750

NAICS

541380 - Testing Laboratories and Services

Place of Performance

Saffron , GB-ESS, GBR

Set-Aside

NONE

Awardee

CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED

Award Issued Date

Documents

0

No documents available

Documents will appear here when they are available.

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Timeline

PhaseAwarded
Posted

Award Notice

Awarded

Contract was awarded

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → Program Support Center Acq Management Svc
Contacts1 person available
OfficeROCKVILLE, MD, 20857, USA
Organization / AgencyDepartment Of Health And Human Services → Program Support Center Acq Management Svc
Office AddressROCKVILLE, MD, 20857, USA
Contacts
Elizabeth Bulger
contact@example.gov

Full Description

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This is a Firm Fixed Priced purchase order.  NCI solicited and negotiated directly with Charles River Discovery Research Services UK Limited.  The National Cancer Institute (NCI) has a program to use an antibody called, 'A10' to target cancer cells that have a lot of the epidermal growth factor receptor on their cell surface. While this antibody has been extensively tested and characterized it is not known if it also binds any other cell surface proteins. The contractor shall perform an off-target screen on an NCI antibody and report back on any problematic interactions that could predict a serious side effect should the antibody be given to a cancer patient. The A10 is NOT known to bind other cell surface proteins or secreted proteins but this needs to be addressed in the off-target screen.

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