This Subcontract opportunity from National Aeronautics And Space Administration was posted on October 17, 2025. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Secure Navigation Algorithm Development and Testing

Closed

Federal

Submission Closed10/31/2025, 02:00:00 PM CDT

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541715

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Solicitation # HT9427-27-SSN-701

The Defense Health Agency Contracting Activity, acting for the Portfolio Acquisition Executive for Medical Products and the Warfighter Protection and Acute Care Project Management Office, intends to issue a sole-source contract modification to Westat Inc. This action is designed to update the SAFE-PLASMA Protocol clinical trial design to align with FDA recommendations and ensure the trial is conducted in accordance with Good Clinical Practices (GCP). The primary objective is to evaluate the safety of EZPLAZ and conventional plasma products in adult patients to meet the necessary requirements for EZPLAZ approval. The scope of work includes the implementation of a specific protocol and Statistical Analysis Plan. This effort is categorized under NAICS code 541715 and is managed by the Defense Health Agency with performance located in Maryland. As this is currently a Sources Sought Notice for market research and planning purposes, the agency is seeking capability statements from interested sources, including technical data and rough order of magnitude estimates, to be submitted via email by November 16, 2026.

Defense Health Agency

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Prototype development for Battlefield Wound Infection Prevention and Treatment (BWI P&T) Barrier Combination

Solicitation # HT9427-26-R-E020

The Defense Health Agency Contracting Activity is seeking a single award to develop a Battlefield Wound Infection Prevention and Treatment Barrier Combination prototype. This medical product must integrate a physical wound barrier with antimicrobial and antifungal properties to prevent the spread of organisms and systemic infections in combat scenarios. The project aims to advance technologies starting at Technology Readiness Level 5 or higher, with the ultimate goal of achieving TRL 7 or 8. Key requirements include the execution of preclinical testing and human clinical trials, the development of Chemistry, Manufacturing, and Controls documentation, and the successful submission for FDA approval or clearance. The procurement is conducted under prototype Other Transaction Authority 10 U.S.C. 4022, meaning it utilizes a tailored agreement rather than standard FAR-based contract structures. The estimated period of performance is 48 months, divided into three primary objectives: prototype demonstration, clinical studies and regulatory submissions, and final FDA clearance. The final deliverable includes up to 50 final design prototypes for operational testing. Packaging must be individual, waterproof, and capable of being opened with gloved hands in low-light environments, while maintaining sterilization and resisting temperatures between 0 and 110 degrees Fahrenheit. Proposals are evaluated based on technical capability, management capability, and cost. Eligible participants are typically small businesses or nontraditional defense contractors; otherwise, a one-third non-federal cost share is required. Awardees must maintain active SAM registration and comply with CMMC cybersecurity frameworks and DoD instructions for Controlled Unclassified Information. Payments are processed electronically via Wide Area Workflow within 30 days of an acceptable invoice.

Defense Health Agency

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Innovative Solutions Canada Program Call for Proposals – 004

Solicitation # EN578-24ISC4

Public Works and Government Services Canada, acting on behalf of Innovation, Science and Economic Development Canada’s Innovative Solutions Canada program, is seeking innovative, pre-commercial solutions from eligible small businesses to address challenges faced by federal departments. This Call for Proposals enables participation in the Challenge Stream, which supports innovation development through two phases: Phase 1 focuses on proving feasibility for technologies at TRL 1-4, while Phase 2 targets prototype development for innovations at TRL 5-9. Proposals may be submitted directly to Phase 2 if specified in the individual challenge notice, or after successful completion of Phase 1, though advancement to Phase 2 is not guaranteed and is at Canada’s sole discretion. Participants must be for-profit companies incorporated in Canada with 499 or fewer full-time equivalent employees, performing R&D in Canada, and meeting specific ownership, wage, and executive residency thresholds that include affiliated entities. Solutions advancing through the program may become eligible for the Testing Stream to support prototype evaluation or the Pathway to Commercialization for potential procurement by the government, with inclusion on the PTC list valid for up to three years. The solicitation remains open for ongoing challenge postings, with this specific iteration, EN578-24ISC4, having a deadline of December 24, 2026. All proposals must be submitted via the CanadaBuys website, and eligibility must be certified at submission and reaffirmed at each stage of the process.

Department of Public Works and Government Services

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RFA: Maryland Pediatric Cancer Fund Research Grants

Solicitation # BPM059686

The Maryland Department of Health, through the Center for Cancer Prevention and Control, is issuing a Request for Applications for pediatric cancer research grants under the Maryland Pediatric Cancer Fund. The agency intends to make up to 12 awards, with each award providing no more than $200,000 per year for a two-year period. The performance period is divided into two annual cycles, running from July 1, 2027, through June 30, 2029. Eligible research categories include basic, applied, clinical, translational, and community-based participatory research. Applications must be submitted via eMaryland Marketplace Advantage by January 29, 2027, and must be organized into two separate volumes: a Project Narrative and a Budget with Narrative. Evaluation is based on a 1-9 scoring system, where 1 is exceptional and 9 is poor, with the final funding determination made by the Maryland Department of Health. Grantees must adhere to strict financial and legal requirements, including the provision of a detailed budget before funds are distributed and the submission of itemized expenditure reports within 60 days of the grant period's close. Compliance with the Americans with Disabilities Act, Title VI of the Civil Rights Act, and the Pro-Children Act of 1994 is mandatory. Additionally, grantees expending $750,000 or more in federal assistance are subject to single audit requirements under 2 CFR 200, and all awardees must provide proof of insurance from a company authorized to do business in Maryland.

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Request for Information (RFI): Seeking New and Emerging Areas of Science Relevant to the NIDCD Mission, To Inform an Update of the NIDCD Strategic Plan for 2028-2032

Solicitation # NOT-DC-26-008

The National Institute on Deafness and Other Communication Disorders is issuing a Request for Information to gather input on new and emerging scientific areas to inform the development of its 2028-2032 Strategic Plan. In accordance with the 21st Century Cures Act, the agency is seeking suggestions from the general public, academic researchers, clinical practitioners, and advocacy groups regarding advancements in hearing, balance, taste, smell, voice, speech, and language that are not currently addressed in the 2023-2027 plan. Interested parties must submit their electronic responses by December 11, 2026. This process is voluntary and intended solely for planning purposes; it is not a solicitation for grant applications or proposals, and no awards will be made based on the submissions. Respondents are cautioned not to include proprietary or personally identifiable information, as the government cannot guarantee confidentiality and may use the submitted data in future reports or funding opportunity announcements.

National Institute On Deafness And Other Communication Disorders

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Request for Information: Developing Menopause Common Data Elements

Solicitation # NOT-OD-26-111

The National Institutes of Health (NIH) has issued a Request for Information to gather input for the development of Common Data Elements (CDEs) focused on menopause. The goal is to create a standardized set of questions and response options to improve the consistency, interoperability, and reproducibility of data collected across research, clinical care, and public health settings. By harmonizing how menopause-related data is recorded, the NIH aims to better understand women's midlife health and the long-term impacts of various treatments. The NIH is seeking feedback on priority domains, including menstrual history, menopausal status, symptoms, biomarkers, and patient-reported outcomes. The proposed framework suggests a tiered approach consisting of core elements for universal collection, supplemental elements for specific thematic aims, and exploratory elements for emerging technologies and biomarkers. Additionally, the initiative seeks guidance on aligning these elements with existing health standards, ensuring representation across diverse populations, and minimizing the burden on participants and providers during implementation.

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Guidance, Navigation, and Control (GNC) AlgorithmsThis subcontract focuses on the design and development of control systems and software algorithms for prime contractors supporting DARPA Anzio spacecraft projects. The scope of work includes the creation of flight control laws, autonomous guidance systems, and trajectory optimization algorithms, all developed using high-fidelity flight simulation software. The primary deliverables for this effort are control system software and detailed simulation performance reports. Managed under the Department of Defense for the Defense Advanced Research Projects Agency, the project falls under NAICS code 541715. Due to the sensitive nature of the work, contractors must maintain strict cybersecurity standards, specifically requiring compliance with NIST SP 800-171 and CMMC Level 2. The solicitation was posted on November 9, 2026, with a response deadline of December 1, 2026.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

HERMES BAA CALL: Rotating Detonation Rocket Engine-Combined Cycle (RDRE-CC) Flight Demonstration

Solicitation # FA9300-20-S-0001-CALL-RDRE-CC

The Air Force Research Laboratory Rocket Propulsion Division is seeking innovative research and development to advance Rotating Detonation Rocket Engine-Combined Cycle propulsion systems from TRL 3 to TRL 6. This effort aims to culminate in a ground-launched flight demonstration to support High-Speed Affordable Mass Munitions. The acquisition follows a two-step process, beginning with the submission of a technical white paper and rough order of magnitude cost, with selected offerors later invited to submit full technical and cost proposals. The anticipated period of performance is 36 to 48 months. Key submission requirements include a ten-page core white paper and an optional five-page technical appendix. While narrative text must be double-spaced, single-spacing is permitted within tables and graphics. Due to the presence of Controlled Unclassified Information, submissions must be sent via DoD SAFE drop requests to Contracting Officers Mathew Pierson and Kameelah Purdom, as the generic workflow inbox is no longer in use. Additionally, the government will utilize a non-government advisor from Sierra Lobo, Inc. for technical evaluation, and vetted contractors must use their CAGE code to access controlled technical Q&A documents via SAM.gov.

POSTED

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Venous Thrombosis (VT)

Solicitation # 80JSC026Q0014

Solicitation 80JSC026Q0014 is a combined synopsis and request for quotations issued by the NASA Johnson Space Center for a firm-fixed-price contract. The project seeks applied research and the development of current or novel approaches to surveil, reduce risk of, and prevent or treat venous thrombosis during spaceflight and exploration missions. The scope of work encompasses preflight medical screening, individual risk assessments, monitoring approaches, and both prophylactic and treatment countermeasures. Specifically excluded from this requirement are pharmaceutical treatments, AI/ML modeling, Earth-independent decision-making tools, and tissue chip or organoid pathophysiology development. The contract features a base period of performance from January 7, 2027, to September 30, 2031, with four optional years. This is a full and open competition for commercial products under NAICS code 541715. Award decisions will be based on a two-step evaluation process consisting of a compliance check followed by a trade-off analysis. Technical acceptability and past performance are weighted as significantly more important than price. Proposals must adhere to Dual-Anonymous Peer Review guidelines, separating attributable information from the technical quote. All responses must be submitted electronically by 1:00 PM CST on November 20, 2026, with technical and contractual questions due by October 30, 2026.

NASA Johnson Space Center

POSTED

DEADLINE

Solicitation # DARPA-SN-27-06

The Anzio program, managed by the Defense Advanced Research Projects Agency Tactical Technology Office, focuses on developing innovative aero-assist technologies for spacecraft to enable large, rapid, and precise orbit transfers while reducing propellant requirements. Key areas of interest include thermal protection systems, control systems and algorithms, atmospheric sensing, and lightweight aeroshells. The program specifically excludes technology areas such as communications, power management, spacecraft buses, payloads, propulsion systems, and existing orbital transfer vehicles. This specific notice, DARPA-SN-27-06, is a Special Notice for an Industry Day event scheduled for December 16-17, 2026, in Arlington, Virginia. It is not a formal solicitation for proposals or abstracts. Interested parties must register and submit PDF posters for approval by December 1, 2026. To handle Controlled Unclassified Information, participants must comply with NIST Special Publication 800-171 and maintain a CMMC Level 2 Self Assessment. All inquiries regarding the notice should be directed to [email hidden].

Defense Advanced Research Projects Agcy

POSTED

1 day ago

DEADLINE

in 21 days

AI Contract Overview

The NASA Marshall Space Flight Center is seeking a subcontractor for the development and testing of secure navigation algorithms. This project focuses on the implementation of cryptographic GPS technology and secure signal processing, utilizing GNSS simulation to ensure the integrity and security of navigation systems. The performance of this contract will take place in Huntsville, Alabama. Interested parties must submit their responses by October 31, 2025, in accordance with the solicitation posted on October 17, 2025. The work falls under NAICS code 541715, pertaining to research and development in the physical, engineering, and life sciences.