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Somatic Mosaicism across Human Tissues (SMaHT) Program: Tissue Procurement Center (R24 Clinical Trial Not Allowed)

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Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

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The National Institutes of Health is seeking a Tissue Procurement Center to support the Somatic Mosaicism across Human Tissues (SMaHT) Network. The primary goal of this initiative is to advance the understanding of biological processes and disease mechanisms driven by somatic mutations in human tissues. The center will be responsible for the collection, processing, storage, and distribution of high-quality human tissue specimens to enable functional analyses and the characterization of somatic mosaicism. The program aims to expand its existing foundation of 150 healthy donors by procuring tissues from at least 50 additional healthy individuals, reaching a total of 200. Additionally, the center will collect up to 10 special tissue cohorts, which may include clinically relevant samples, tissues suitable for culture, or organs requiring specialized handling. The awardee will collaborate with other SMaHT Stage 2 initiatives to ensure that all samples are sufficient for production-level assays.

General Info

NIH seeks a center to procure, store, and distribute human tissue specimens.

Agency

Department Of Health And Human Services → National Institutes Of HealthView Agency

NAICS

621991 - Blood and Organ BanksView NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(0)

No documents available

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health
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Office AddressUSA
Contacts
SMaHT Program
contact@example.gov

Full Description

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The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. 

Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for the SMaHT Tissue Procurement Center (TPC) initiative.  

The TPC will enable functional analyses of these healthy and clinically relevant tissue samples, providing critical resources to support characterization of somatic mosaicism and its role in human biology and disease. The Tissue Procurement Center will support the Network by collecting, processing, storing, and rapidly distributing high-quality, well-characterized human tissue specimens. Building on the 150 healthy donors enrolled during Stage 1, the TPC will procure tissues from at least 50 additional healthy donors, bringing the total to 200. The TPC will also collect up to 10 special tissue cohorts. The special tissue cohorts may include: tissues that can be grown in culture, tissues that are of high interest for somatic mosaicism studies, clinically relevant samples, organs that require special handling procedures, and other relevant samples. Awardee will collaborate with other SMaHT Stage 2 initiatives to ensure that the samples are sufficient and useful for running production level assays within the program. 

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