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Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)

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RFA-HG-27-007Grant

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The National Human Genome Research Institute, under the National Institutes of Health, is soliciting applications through solicitation RFA-HG-27-007 to characterize genomic variation and assess how individual variants impact genome function. The initiative focuses on systematically perturbing variants using high-throughput methods to collect data on the effects of DNA, RNA, or protein-coding elements on various phenotypes. Additionally, selected participants must develop portable and reproducible data processing pipelines to support these findings. Awarded centers will join the Impact of Genomic Variation on Function Consortium, requiring them to collaborate on assays, cell types, and analysis strategies to ensure resources are accessible to a broad user base. Interested parties must submit their responses by December 15, 2026. It is important to note that clinical trials are not allowed under this specific funding opportunity.

General Info

NHGRI seeks applications for genomic variation research and data pipelines by December 15, 2026.

Agency

National Institutes Of Health → National Human Genome Research Institute

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Not specified

Set-Aside

NONE

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Organization & Contact Information

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AgencyNational Institutes Of Health → National Human Genome Research Institute
ContactsNo contacts available
OfficeUSA
Organization / AgencyNational Institutes Of Health → National Human Genome Research Institute
Office AddressUSA
ContactsNo contact information available

Full Description

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The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to characterize genomic variation to assess the impact of individual variants on genome function. This will be accomplished by systematically perturbing variants or elements using one or more high-throughput methods; collecting data on the effects of variants in DNA, RNA, or protein-coding elements on molecular, cellular, or organismal phenotypes; and developing robust, reproducible, and portable data processing pipelines. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.

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