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The scope of this work is perform confirmatory in vitro assays against specific molecular targets and/or signaling pathways. Putative targets of xenobiotic chemicals will be identified by EPA through…

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The Environmental Protection Agency is seeking a contractor to perform confirmatory in vitro assays targeting specific molecular targets and signaling pathways. This work is designed to test hypotheses regarding the effects of xenobiotic chemicals, which the EPA will identify using transcriptomics profiling in human cells. The project requires access to a broad spectrum of in vitro assays to ensure diverse coverage of potential targets. These targets may include, but are not limited to, enzymes, nuclear receptors, G protein-coupled receptors, and ion channels.

General Info

EPA seeks contractor for in vitro assays testing xenobiotic chemical effects on molecular targets.

Agency

Environmental Protection Agency

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

0

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Documents will appear here when they are available.

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Organization & Contact Information

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AgencyEnvironmental Protection Agency

ContactsNo contacts available

OfficeN/A

Organization / AgencyEnvironmental Protection Agency

Office AddressN/A

ContactsNo contact information available

Full Description

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The scope of this work is perform confirmatory in vitro assays against specific molecular targets and/or signaling pathways. Putative targets of xenobiotic chemicals will be identified by EPA through transcriptomics profiling in human cells and the EPA requires access to in vitro assays covering a wide range of potential targets to test the hypotheses developed from the transcriptomics profiling. Diverse coverage of targets could include ion channels, GPCR�s, nuclear receptors, enzymes, etc.

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