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Transformative Non-Invasive/Minimally Invasive Technologies for Imaging the Olfactory System Across Scales (R01 CT Optional)

Active

RFA-DC-27-003Grant

Response Deadline08/21/2028, 04:00:00 AM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

The National Institute on Deafness and Other Communication Disorders (NIDCD), in partnership with the National Institute of Biomedical Imaging and Bioengineering (NIBIB), is seeking proposals to advance transformative, high-resolution, and high-specificity in vivo imaging technologies for the human olfactory system. This initiative addresses the current gap in non-invasive or minimally invasive imaging methods that can effectively visualize both the peripheral and central olfactory structures with superior spatial and temporal resolution. The inherent challenges in imaging the olfactory system, including its complex anatomy, varied cell types, and low signal resolution, require innovative, multimodal approaches that incorporate existing advanced tools and the development of new technologies tailored specifically for this system. Eligible projects must focus on leveraging cutting-edge imaging technologies such as cell-specific biomarkers, fluorescence imaging, specialized endoscopes, optical and acoustic imaging, molecular imaging, and hemodynamic and diffusion imaging to achieve visualization capabilities at an unprecedented level. Applications should target both peripheral components, including olfactory and non-olfactory epithelium, and central olfactory areas like the olfactory bulb. Collaborations among multidisciplinary teams with expertise in olfaction, biomedical imaging, biochemistry, bioengineering, and biophysics are strongly encouraged to ensure comprehensive and innovative approaches. The solicitation, released by the Department of Health and Human Services through the NIH, invites responses by August 21, 2028, offering a strategic opportunity to improve diagnostic tools and deepen understanding of olfactory disorders.

General Info

NIDCD and NIBIB seek proposals for advanced, high-resolution in vivo olfactory system imaging technologies.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

Not specified

Set-Aside

NONE

Documents

(1)

RFA-DC-27-003 - Transformative Non-Invasive Imaging Technologies

HTML•27 pages•rfa

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseSolicitation

PostedMay 20

Solicitation

Response DeadlineAug 21

Submission deadline

Response Deadline

08/21/2028, 04:00:00 AM UTCin almost 2 years

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health

Contacts1 person available

OfficeUSA

Organization / Agency

Department Of Health And Human Services → National Institutes Of Health

Office AddressUSA

Contacts

National Institutes of Health

contact@example.gov

+1 (555) 000-0000

Full Description

The National Institute on Deafness and Other Communication Disorders (NIDCD), with the National Institute of Biomedical Imaging and Bioengineering (NIBIB) aims to support the development and/or adaptation of transformative in vivo high-resolution/high specificity imaging of the human olfactory system. Currently, there are limited non-invasive/minimally invasive technologies available for imaging the living human peripheral and central olfactory system with high spatial and temporal resolution. Imaging the olfactory system in the laboratory and in the clinic is essential to understanding underlying biological mechanisms as well as the etiology of an olfactory disorder. Such imaging has proven challenging due to the olfactory system"s unique anatomical and functional characteristics such as restricted accessibility, multiple cell types, and low signal resolution. Addressing these challenges requires multimodal approaches including leveraging existing advanced tools and technologies and developing new tools tailored for the olfactory system. Recent advances in minimally invasive and non-invasive imaging technologies, such as cell specific biomarkers, fluorescence imaging, specialized endoscopes, optical and acoustic imaging, molecular imaging, and hemodynamic and diffusion imaging have the potential to transform our ability to image and investigate the peripheral and central olfactory system in the living human with superior temporal and spatial resolution and eventually improve diagnostic accuracy of olfactory disorders. Applications must leverage advanced non-invasive/minimally invasive imaging technologies to visualize peripheral (e.g., olfactory- and non-olfactory epithelium) and central olfactory (e.g., olfactory bulb) targets at a level previously unattainable. In addition, projects should engage multidisciplinary teams combining expertise in olfaction, biomedical imaging, biochemistry, bioengineering, and biophysics, as appropriate.