Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement Clinical Trial Optional)

The National Institutes of Health (NIH) plans to release a Notice of Funding Opportunity (NOFO) to invite applications for urgent competitive revisions to existing grants and cooperative agreements. These revisions aim to address unexpected public health crises that were not anticipated at the time the original grant application was submitted. Once this NOFO is published, applications for these urgent supplements will be directed to the NIH awarding component responsible for the most recent parent award. Only applications responding to specific Urgent Guide Notices issued by an NIH Institute or Center (IC) will be eligible to apply under this NOFO. This funding opportunity supports expedited amendments to ongoing grants to facilitate rapid responses to emergent health challenges, allowing flexibility in addressing pressing public health needs. The program accommodates clinical trials as optional components within these urgent revision applications. The point of contact for this initiative is the Division of Grants Policy within the NIH Office of Policy for Extramural Research Administration, which can be reached via email for guidance. The NOFO is expected to enhance the NIH’s ability to swiftly mobilize resources in response to unforeseen health emergencies.