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4J THERAPEUTICS INC

UEI: SZCGV7LQJKR4CAGE: 9DFF0

4J THERAPEUTICS INC is a federal contractor, registered under UEI SZCGV7LQJKR4 and CAGE code 9DFF0. It has been awarded $63,083,816 in federal contracts. Primary work spans Research and Development in Biotechnology (except Nanobiotechnology). Top awarding agencies include Department Of Health And Human Services.

Contact Information

Registration and classification details

Registration

UEI Code

SZCGV7LQJKR4

CAGE Code

9DFF0

Entity Structure

Corporate Entity (Not Tax Exempt)

Established

N/A

Business Classifications

For Profit Organization

NAICS Codes

541714Research and Development in Biotechnology (except Nanobiotechnology)(Primary)

Federal Contracting Overview

Award totals, agency breakdown, NAICS distribution, and geographic footprint.

AI Capability Profile

4J Therapeutics Inc. specializes in the research and development of programmable antiviral technologies, focusing on the design, preclinical validation, and early-stage clinical evaluation of novel therapeutic platforms. Their core expertise lies in nucleic acid-based drug discovery, particularly le...

4J Therapeutics Inc. specializes in the research and development of programmable antiviral technologies, focusing on the design, preclinical validation, and early-stage clinical evaluation of novel therapeutic platforms. Their core expertise lies in nucleic acid-based drug discovery, particularly leveraging locked nucleic acid (LNA) chemistries to engineer targeted antiviral agents with high specificity and potency. The company develops end-to-end preclinical packages, including pharmacokinetic profiling, toxicology studies, and formulation science, to advance candidates into first-in-human Phase 1A trials. Their technical differentiator is the modular design of their platform, enabling rapid adaptation to emerging viral threats while maintaining robust safety and manufacturability profiles. This positions them at the intersection of molecular virology, oligonucleotide therapeutics, and translational medicine. The company has demonstrated direct engagement with the Department of Health and Human Services, where its work supports public health preparedness through the advancement of next-generation antiviral candidates. This relationship reflects a focus on mission-critical biodefense and infectious disease innovation aligned with HHS’s strategic priorities in pandemic response and biomedical R&D. 4J Therapeutics operates primarily within NAICS 541714, which encompasses biotechnology research aimed at therapeutic discovery and development outside of nanobiotechnology. Their vertical specialization is in antiviral platform technologies, with a clear emphasis on RNA-targeting modalities and early-phase clinical translation. This niche places them within the broader landscape of precision antiviral biotech, serving government-funded initiatives focused on novel therapeutic pipelines. As a small business structured as a 2L entity based in Palo Alto, California, 4J Therapeutics leverages its location within a global biotech hub to access scientific talent and research infrastructure. While currently holding no formal government certifications, its focused R&D model and direct engagement with HHS underscore its role as a specialized innovator in the federal biodefense and therapeutic development ecosystem.

Key Performance Metrics

Awards Count

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Active

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Past period of performance

Total Awards

All time

Contracts

Prime · all time

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Grants

Prime · all time

Subgrants

Sub · all time

Award Analytics & Distribution

Awards by Agency
Awards by NAICS
Awards by Agency Over Time
Awards by Place of Performance

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NAICS: 541714
New
Federal
DNA Sequencing Service
Solicitation # PCA-NIEHS-00080
The National Institutes of Health, through the National Institute of Environmental Health Sciences, is issuing a Small Business Sources Sought notice for solicitation PCA-NIEHS-00080 to identify capable providers for an indefinite-delivery indefinite-quantity contract. The requirement is for DNA sequencing services and associated bioinformatics support, primarily utilizing Sanger sequencing with a smaller volume of high-throughput whole-plasmid sequencing. The estimated workload is between 2,000 and 3,000 samples per month, including yeast colonies, plasmid DNA, and PCR-generated samples from human and rodent species. The intended period of performance is five years from the date of award, with a potential six-month extension per FAR 52.217-8. The selected contractor must provide a web-based ordering and tracking system, all necessary sample collection and shipping materials, and a reliable transportation method for samples from the NIEHS campus in Research Triangle Park, North Carolina. Key technical requirements include maintaining a Phred-equivalent quality score greater than 20 for sequencing and ensuring successful PCR amplification produces a single DNA band of the expected size. The contractor is responsible for preserving remaining DNA for at least 180 days and returning unused primers to the government. Administrative requirements include submitting invoices within ten business days of the billing cycle and maintaining strict confidentiality of all sequencing data. This notice is specifically targeting small business concerns, including 8(a), SDB, WOSB, HUBZone, VOSB, and SDVOSB designations. Interested parties must submit a capability statement of no more than seven pages, including their UEI, TIN, and business size certification, to Luz Casey by November 12, 2026.
National Institutes Of Health Olao

POSTED

1 day ago

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in 9 days
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NAICS: 541714
New
Federal
FY27 FDA Broad Agency Announcement (BAA) for Advanced Research and Development of Regulatory Science
Solicitation # FDABAA-27-00123
The FY27 FDA Broad Agency Announcement (BAA), solicitation number FDABAA-27-00123, seeks basic and applied research and development proposals to advance regulatory science and innovation. Managed by the FDA Office of Acquisitions and Grant Services, this initiative aims to utilize capabilities from industry and academia to improve technologies, materials, processes, and methods that support the FDA's mission to protect and promote national health. The BAA is open to all responsible sources, with strong encouragement for small business participation. Proposals are evaluated based on overall best value, focusing on scientific and technical merit, the degree of innovation, the feasibility of proposed plans, and the potential to overcome critical barriers in the field. Submissions must be delivered as searchable PDFs via email by January 22, 2027, at 5:00 PM EST. The application process requires a concept paper limited to three pages and a full proposal divided into a technical volume (50-page limit) and a cost volume. Key requirements include valid SAM.gov registration, adherence to strict page limits, and the provision of detailed key personnel qualifications. Awardees must comply with specific regulatory standards, including Good Manufacturing Practice (GMP), Good Laboratory Practice (GLP), and Good Clinical Practice (GCP) where applicable. Additionally, contractors must maintain strict organizational conflict of interest disclosures and provide monthly technical progress reports. Non-small business concerns submitting proposals exceeding 900,000 dollars are required to provide a Small Business Subcontracting Plan.
FDA Office Of Acq Grant Svcs

POSTED

4 days ago

DEADLINE

in 3 months
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NAICS: 541714
New
Grant
Cooperative Agreement for affiliated Partner with Great Basin Cooperative Ecosystem Studies Unit
Solicitation # G27AS00044
The U.S. Geological Survey is seeking a Cooperative Ecosystem Studies Units partner from the Great Basin unit to enhance species barcode libraries for riverine macroinvertebrates in the Rocky Mountain region. This research initiative supports a pilot project evaluating metagenomics and environmental DNA metabarcoding to monitor aquatic ecosystems, utilizing field samples and geospatial datasets to develop artificial intelligence and machine-learning models for predicting community composition. The project is funded through a cooperative agreement with a total estimated program funding of 250,000 dollars for a two-year budget period, with one award expected. Applicants must submit proposals via Grants.gov by December 1, 2026, and must be registered in SAM.gov. Required documentation includes a project narrative, detailed budget, Project Abstract Summary, and biographical sketches and current and pending support forms for key personnel. Evaluation is based on documentation completeness, basic eligibility, technical merit, budget reasonableness, and the absence of programmatic overlap. Awardees must adhere to USGS Fundamental Science Practices and the Geospatial Data Act of 2018, ensuring all digital GIS data is submitted in open formats with complete metadata. Performance is monitored through annual financial reports and a final technical report due 120 days after the period of performance ends, with funds disbursed through the Department of the Treasury Automated Standard Application for Payments system.
US Geological Survey

POSTED

4 days ago

DEADLINE

in 29 days
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NAICS: 541714
New
Grant
Genomic Data Generation Center for the Gabriella Miller Kids First Pediatric Research Program (U24 Clinical Trial Not Allowed)
Solicitation # RFA-RM-27-008
The National Institutes of Health, under the Department of Health and Human Services, is seeking applications for Genomic Data Generation Center(s) to support the Gabriella Miller Kids First Pediatric Research Program. The primary objective is the rapid production of high-quality sequence and variant data from human specimens related to pediatric conditions, specifically childhood cancers and congenital anomalies. Required data types include genome-wide, RNA, and long-read DNA and RNA sequencing, as well as chromatin accessibility data and genome-wide methylation profiling. All generated data will be re-processed and harmonized by the Kids First Pediatric Data Resource Center to maintain a public-facing, cloud-based resource for the research community. The NIH Common Fund intends to commit 5 to 6 million dollars annually for a maximum award period of three years, with an award ceiling of 3.5 million dollars. Applications are due by January 8, 2027, and will be evaluated via the NIH peer review system based on significance, investigator qualifications, innovation, and approach. A key requirement is the center's agility to implement new assays within a two-month timeframe. This opportunity is restricted to projects that do not propose clinical trials. Eligible applicants must maintain active registrations in SAM, eRA Commons, and Grants.gov. Awardees must adhere to strict cybersecurity protocols, including multifactor authentication and a 48-hour incident notification window, and comply with federal regulations 42 CFR Part 52 and 2 CFR Part 200. Proposals must include itemized per-sample costs, a minimum sample estimate, and a plan for cost reduction over the award period. All research involving human subjects must comply with 45 CFR Part 46, and a comprehensive Data Management and Sharing Plan is required at the time of application.
National Institutes Of Health

POSTED

5 days ago

DEADLINE

in 2 months
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NAICS: 541714
New
Federal
High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)
Solicitation # DARPA-PA-27-01
The High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE) program, solicited by the DARPA Biological Technologies Office under DARPA-PA-27-01, seeks to develop an in-silico capability for mapping all protein-protein interactions. The primary objective is to create a comprehensive human interactome hypercatalog capturing over 10 million new interactions, shifting from static biomarkers to dynamic, context-aware interactomes. The utility of this capability will be demonstrated by identifying novel diagnostic and therapeutic targets for traumatic brain injury. Awards will be issued as Other Transaction (OT) for Research agreements with fixed, payable milestones. The program is structured in two phases, with Phase 1 estimated at 12 months and Phase 2 anticipated at 18 months, though current awards are limited to Phase 1. Proposers, including large and small businesses, universities, and research institutions, must submit a maximum six-page unclassified abstract via the Broad Agency Announcement Tool by November 5, 2026, to be considered for an Oral Proposal Package due December 11, 2026. Evaluation is based on technical comprehension, technical ability, and the realism of the cost rough order of magnitude. Prime proposers must be registered in the System for Award Management and demonstrate CMMC Level 1 compliance. Performance will be managed through a Task Description Document and a milestone-based payment schedule, with invoicing processed through the Wide Area Workflow system. Security requirements include the Fundamental Research Risk-Based Security Review Process for all senior and key personnel.
Defense Advanced Research Projects Agcy

POSTED

6 days ago

DEADLINE

in 2 days
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NAICS: 541714
Federal
RFI Alzheimer’s Research Program (AZRP) Public
Solicitation # HT9427RFI2027AZRP
The Defense Health Agency, through the Congressionally Directed Medical Research Programs, has issued a Request for Information under solicitation number HT9427RFI2027AZRP to gather strategic feedback for the fiscal year 2027 Alzheimer’s Research Program. The primary objective is to identify research focus areas and funding opportunities aimed at mitigating the impact of Alzheimer's and related dementias, specifically those associated with traumatic brain injury, military service, and diverse risks. The program seeks to improve the quality of life for Service Members, Veterans, and their families by funding solution-oriented research, including the development of digital and blood-based biomarkers for early diagnosis and the creation of precision prevention strategies. This action is strictly for information and planning purposes and does not constitute a formal solicitation, request for proposals, or request for quotations. No contracts will be awarded based on this announcement, and FY27 funds have not yet been appropriated. Interested parties from academia, industry, non-profit organizations, and federal agencies are invited to provide feedback via Survey Monkey by December 4, 2026. Respondents are cautioned not to submit proprietary or sensitive information through the survey portal as it cannot be protected. The effort is categorized under NAICS code 541714 and is managed by the Department of Defense in Fort Detrick, Maryland.
Defense Health Agency

POSTED

7 days ago

DEADLINE

in about 1 month
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