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Broad Institute, Inc., The MA 02142-1027 USA

UEI: SLED_B3A3F30875730AB3

Broad Institute, Inc., The MA 02142-1027 USA is a federal contractor, registered under UEI SLED_B3A3F30875730AB3. It has been awarded $149,000,000 across 1 federal contract. Primary work spans Research and Development in Biotechnology (except Nanobiotechnology). Top awarding agencies include National Institutes Of Health Nida.

Contact Information

Registration and classification details

Registration

UEI Code

SLED_B3A3F30875730AB3

Federal Contracting Overview

Award totals, agency breakdown, NAICS distribution, and geographic footprint.

Key Performance Metrics

Awards Count

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Award Analytics & Distribution

Awards by Agency

National Institutes Of Health Nida$149.0M100%

Awards by NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)$149.0M100%

Awards by Agency Over Time

Awards by Place of Performance

Open opportunities in Broad Institute, Inc., The MA 02142-1027 USA's top NAICS codes and agencies

Chemical, Biological, Radiological, and Nuclear (CBRN) Medical Countermeasure (MCM) Participant Basic Agreement (PBA)

Solicitation # W911SR-26-R-HEAL

The Chemical, Biological, Radiological, and Nuclear (CBRN) Medical Countermeasure (MCM) Participant Basic Agreement (PBA) is a continuous, open solicitation designed to establish a dynamic, pre-qualified network of partners to accelerate the development and fielding of next-generation medical defenses against CBRN threats. Operated by the Capability Program Executive for CBRN Defense (CPE CBRND) under the Department of Defense, this agreement functions as an Indefinite-Delivery Indefinite-Quantity (IDIQ)-like vehicle authorized under 10 U.S.C. §§4021, 4022, and 4023, exempting it from the Competition in Contracting Act of 1984. The program seeks innovative, threat-agnostic host-directed therapeutics that enhance physiological resilience by targeting critical systems such as neurological function, respiratory stability, immune response, hematologic and vascular integrity, and cellular stress and repair pathways. Complementary to this, the government also seeks broad-spectrum therapeutic candidates that can directly neutralize CBRN agents, with emphasis on agents possessing environmental stability, non-cold-chain storage capability, and simplified administration routes like oral, intranasal, or autoinjector formats suitable for immediate use in austere, far-forward operational environments. Interested parties, including MCM developers at any stage from Phase I through FDA licensure and supporting organizations such as CROs, CDMOs, and regulatory experts, must submit a white paper of no more than five pages detailing product mechanisms, efficacy data from validated animal models, regulatory status including IND history and clinical trial results, manufacturing capacity and scale-up plans, and company experience. Collaboration is mandatory, with applicants required to state willingness to team or partner within the PBA ecosystem. Participation requires SAM registration, and all award decisions are based on technical merit and strategic alignment with the program’s mission to build a layered, resilient, and sustainable medical defense portfolio, without fixed deadlines or competitive bidding. The agreement supports the development of dual-use medical solutions with potential applications in civilian critical care, emphasizing ruggedized formulations, clear labeling, durable packaging, and long-term stability to ensure readiness in the most challenging operational conditions. Technical and administrative inquiries should be directed to Hunter Robinson or Alexander Mayatte at the Aberdeen Proving Ground, Maryland office.

POSTED

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Validation and Optimization of ONE-STEP Tagging in Human induced Pluripotent Stem Cells

Solicitation # NIH-NOI-PCA-NIA-01590

The National Institute on Aging (NIA), under the National Institutes of Health (NIH) and Department of Health and Human Services (HHS), has issued a Notice of Intent to Sole Source for the validation and optimization of ONE-STEP tagging in human induced pluripotent stem cells (iPSCs). This acquisition aims to support the iPSC Neurodegenerative Disease Initiative (iNDI) and the Center of Alzheimer’s Disease and Related Dementias (CARD) by generating functionally engineered iPSC lines for research into Alzheimer’s disease and related dementias. The project involves high-activity guide identification, Bxb1 mRNA and cargo plasmid delivery optimization, and the generation of ADRD variant, MAPT 4R, and wild-type process-control clones. All deliverables must be repository-ready, meeting strict quality control standards including long-read sequencing, karyotype analysis, and SNP arrays to ensure scientific continuity and data integrity. The government intends to award this contract to The Jackson Laboratory, citing them as the only responsible source capable of meeting the requirements under FAR 6.302-1 and FAR 13.501(a). This determination is based on the laboratory's unique continuity with the existing iNDI program, established workflows for specific background lines, and proven success in large-scale CRISPR/Cas9 engineering. The total estimated contract value is 3,353,115.00 dollars, covering a base year from September 1, 2026, to August 31, 2027, and an option year extending to August 31, 2028. While this is a sole-source intent, the government will consider capability statements from other sources submitted by August 21, 2026, to determine if adequate competition exists.

National Institutes Of Health Olao

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Sole Source - Production of ChAdOx-1 and MVA expressing mouse gp70

Solicitation # 75N98026Q00996

The National Cancer Institute intends to award a sole-source, firm fixed price contract under solicitation RFQ 75N98026Q00996 to the Viral Vector Core at the Pandemic Institute, University of Oxford. The project involves the design and production of ChAdOx-1 and MVA viral vectors expressing mouse gp70 and the mouse class II major histocompatibility complex invariant chain. This research is critical for evaluating vaccine efficacy against breast cancer brain metastasis, utilizing proprietary chimpanzee adenovirus technology to avoid pre-existing human adenovirus immunity. The contract falls under NAICS code 541714 for biotechnology research and development and has a performance period of six months from the date of award. Payment terms are set at net 30 days following the acceptance of deliverables. While intended as a sole-source procurement due to the proprietary nature of the technology, the agency will consider capability statements from other interested parties submitted by August 24, 2026.

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Core Research in Biological Sciences (BIO Core)

Solicitation # 26-517

The National Science Foundation's Directorate for Biological Sciences is offering funding through the Core Research in Biological Sciences solicitation 26-517. This opportunity supports foundational and interdisciplinary research across all biological levels, from molecular to biome scales, encompassing both legacy program topics and new areas of biological science. The program provides single- and multi-investigator awards with flexible budgets and durations to accommodate both small exploratory projects and long-term research commitments. These federal awards are subject to the availability of funds and are managed by the National Science Foundation.

National Science Foundation

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in almost 50 years

On-Site Installation and Training ServicesThis subcontract opportunity with the Department of Commerce NIST involves on-site installation, calibration, and training services located in Gaithersburg, Maryland. The scope of work includes system setup and the verification of technical specifications. While these specific services are not mandatory, they will be given additional evaluation consideration if included in the proposal. The project is designated as a total Small Business Set Aside under NAICS code 541714. Interested parties must submit their responses by August 28, 2026, at 1:00 PM. The solicitation was officially posted on August 15, 2026.

Department Of Commerce Nist

POSTED

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Q301--Zymo Epigenome Sequencing Services

Solicitation # 36C24126Q0748

The Department of Veterans Affairs, specifically the VA Bedford Healthcare System, intends to award a sole source, firm-fixed-price contract to Zymo Research Corporation for Reduced Representation Bisulfite Sequencing services. This project involves DNA methylation profiling of 269 post-mortem human choroid plexus tissue samples, encompassing sample handling, quality control, bisulfite conversion, library preparation, sequencing, and data alignment. The scope of work includes generating approximately 30 million read pairs per sample and producing genome browser tracks. This procurement is conducted as a sole source under authority RFO 6.103-1 because Zymo Research Corporation previously generated a prefrontal cortex dataset for the same study. Utilizing the same vendor is critical to avoid technical confounds that would compromise the scientific validity of the cross-tissue comparison. The requirement falls under NAICS code 541714 and PSC Q301. Interested parties must submit responses by August 21, 2026, at 11:00am EST.

241-NETWORK Contract Office 01 (36C241)

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Technical Readiness & Prototype DemonstrationThe Technical Readiness and Prototype Demonstration is a subcontract opportunity issued by the Department of Defense under the FA2553 Oprn Testing and Trg Infr Otti Pk agency. The primary objective of this effort is to demonstrate the technical capability to build, test, and deploy software from commercial facilities into government cloud enclaves, ensuring a secure and automated delivery process. This project falls under NAICS code 541714 and will be performed in Colorado Springs. Interested parties must submit their responses by September 4, 2026, following the posting date of August 13, 2026.

FA2553 Oprn Testing & Trg Infr Otti Pk

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Established Clinician Investigator Award to Support Mentoring (KS1)The Established Clinician Investigator Award to Support Mentoring (KS1) is a forecast opportunity issued by the National Institutes of Health under the Department of Health and Human Services. This award is designed to provide established clinician investigators with a sustained period of protected time, enabling them to deliver high-quality mentoring and guidance to early-career clinician research scientists. The program is managed by the Division of Biomedical Research Workforce, which serves as the primary point of contact for interested parties. While specific performance locations and set-aside details are not listed, the award aims to strengthen the pipeline of clinician researchers through structured mentorship support.

National Institutes Of Health

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Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)The National Institute on Aging is issuing a forecast for the Alzheimer's Drug-Development Program to support the pre-clinical and early-stage clinical Phase I development of novel biologic and small-molecule drug candidates. The program aims to identify treatments that prevent Alzheimer's disease, slow its progression, or address cognitive and behavioral symptoms. Funding is available for academic and biotech researchers to conduct development activities internally or through specialized contract research organizations. The initiative focuses on expanding the portfolio of investigational drug candidates for emerging therapeutic targets and diversifying the therapeutic pipeline to support mono-therapy, combination therapy, and precision medicine approaches. This opportunity will utilize the U01 activity code. While applications are not currently being accepted, this notice serves to allow potential applicants time to establish collaborations and design responsive projects.

National Institutes Of Health

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Online BAAS Hospitality Administration Degree Program Development

Solicitation # 754-TXST-2026-RFP-507-VPGOI

Texas State University is seeking a partner to develop a competitive and differentiated online Bachelor of Applied Arts and Science degree program in Hospitality Administration. The primary objective is to establish a high-quality academic offering where the total credit requirements are determined by the necessary standards to ensure the program remains distinct and competitive within the hospitality education market. This solicitation, identified by number 754-TXST-2026-RFP-507-VPGOI, was posted on August 12, 2026, with a response deadline of September 18, 2026. The project is managed by Texas State University in Texas, with Dan Alden serving as the primary point of contact for interested parties.

Texas State University

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in about 1 month

Artificial Intelligence (AI) System Integration and GovernanceThis subcontract, titled Artificial Intelligence (AI) System Integration and Governance, is issued by the Texas Health and Human Services Commission. The project focuses on the integration of AI tools designed for administrative automation and case analysis. All implementations are strictly subject to ethical governance standards and require prior written approval from the Department of Family and Protective Services. The opportunity was posted on August 12, 2026, with a response deadline of September 3, 2026. It is categorized under NAICS code 541714, reflecting a focus on customized computer programming services. Interested parties can find further details through the Texas SmartBuy portal.

Health and Human Services Commission

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FDA-Cleared AI-Based Contouring IntegrationThe Department of Veterans Affairs, through Network Contract Office 16, is seeking a subcontract for the integration of AutoContour, an FDA-cleared AI system. This technology is designed to provide automated anatomical structure delineation to enhance radiation oncology treatment planning. The project will be performed in Jackson, Mississippi, under NAICS code 541714. Interested parties must submit their responses by August 21, 2026, at 3:00 PM. The solicitation was officially posted on August 12, 2026, and focuses on implementing advanced artificial intelligence to streamline clinical workflows within the VA healthcare system.

256-NETWORK Contract Office 16 (36C256)

POSTED

DEADLINE

Medicinal Chemistry Support Program for Therapeutic Development (MCSP)

Solicitation # 75N98026R00144SB

This Small Business Sources Sought notice is issued by the National Institutes of Health to identify qualified small business sources capable of providing comprehensive medicinal chemistry services for the Medicinal Chemistry Support Program for Therapeutic Development. The government seeks a turn-key operation to support preclinical drug discovery efforts, including exploratory, hit-to-lead, and lead optimization phases. Required capabilities include SAR analysis and design, synthesis, in vitro ADMET studies, computational chemistry, and compound logistics. Vendors must demonstrate the capacity to manage one to ten concurrent projects and possess the necessary technical personnel and facilities to scale operations as needed. Interested small businesses under NAICS code 541715 must submit detailed responses by September 14, 2026, addressing their in-house capabilities, professional experience, and staffing qualifications. The government is using this notice to determine if the requirement can be set aside exclusively for small businesses and to evaluate whether the services should be classified as commercial or research and development. Responses should be emailed to the designated points of contact and must include the organization's Unique Entity Identifier and small business status. This notice is for research purposes only and is not a formal solicitation for proposals.

National Institutes Of Health Nida

POSTED

DEADLINE

Medicinal Chemistry Support Program for Therapeutic Development (MCSP)

Solicitation # 75N98026R00144

This Sources Sought notice is issued by the National Institutes of Health to identify qualified vendors capable of providing comprehensive medicinal chemistry services for the Medicinal Chemistry Support Program for Therapeutic Development. The government is seeking a full-service, turn-key operation to support preclinical drug discovery efforts, including exploratory, hit-to-lead, and lead optimization phases. Required capabilities include SAR analysis and design, synthesis, in vitro ADMET studies, computational chemistry, and compound logistics. Vendors must demonstrate the ability to manage between one and ten concurrent projects and provide detailed information regarding their staffing, facilities, and experience in advancing compounds toward Phase 1 clinical testing. The primary objective of this notice is to conduct market research to determine the availability of qualified sources and assess whether the requirement can be set aside for small businesses under NAICS code 541715. The government has preliminarily determined that these services are not commercial in nature, though vendors are encouraged to provide evidence if they believe the services are commercial. Interested parties must submit a detailed response by September 14, 2026, including their Unique Entity Identifier and business size status. This is not a solicitation for proposals, and the government is not responsible for any costs incurred during the response process.

National Institutes Of Health Nida

POSTED

DEADLINE

Bioinspired Anti-Icing Molecule Development

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Bioinformatics Integration & Data Pipeline SetupThis subcontract, titled Bioinformatics Integration and Data Pipeline Setup, is issued by the Department of the Interior through the Ibc Acq Svcs Directorate. The primary objective is to configure software and integrate the AVITI24 system with institutional data frameworks. This includes the development of automated export, backup, and analysis pipelines that must strictly adhere to NIH data policies. The opportunity was posted on August 11, 2026, with a response deadline of August 27, 2026. It is categorized under NAICS code 541714, focusing on specialized research and scholarly activities to ensure seamless data integration and compliance within the institutional environment.

Ibc Acq Svcs Directorate (00004)

POSTED

DEADLINE

Future Program: Intrinsic Market Resilience (IMR)

Solicitation # DARPA-SN-26-110

The Intrinsic Market Resilience (IMR) program, issued by the Defense Advanced Research Projects Agency under solicitation DARPA-SN-26-110, seeks to protect critical economic sectors from systemic risks and adversarial attacks targeting modern electronic market interfaces. While current regulations focus on profit-driven manipulation, this initiative addresses the gap in protecting markets from actors intending to cause general disruption and economic chaos. The program aims to ensure the stability of civilian and military resources by making market designs fundamentally more resilient to attack. To achieve this, the IMR program will integrate Large Language Model automation with rigorous mathematical modeling to identify and repair hidden market weaknesses. The technical approach involves creating formal notations from regulatory and technical specifications to develop machine-analyzable models. By formulating resilience conjectures, the program will prove market stability or generate counterexamples to identify vulnerabilities, ultimately recommending specific design repairs to safeguard the integrity of U.S. markets.

Defense Advanced Research Projects Agcy

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Hypoxia Chamber Services

Solicitation # 80JSC026Q0008

NASA Johnson Space Center is soliciting offers for Hypoxia Chamber Services under solicitation number 80JSC026Q0008 to support research on the physiological, cognitive, and clinical effects of mild hypobaric hypoxia as part of the Artemis Program. The contract requires comprehensive services including infrastructure, personnel, training, materials, food, supplies, and operational support necessary to conduct controlled hypoxia experiments. This is a combined synopsis and solicitation issued under FAR Subpart 12.6, with no written solicitation to follow, and all information is contained within the posted notice and attachments, particularly Attachment A for the Performance Work Statement and Attachment D for additional submission requirements. The NAICS code is 541714 with a size standard of 1,000 employees, and offerors must self-certify their size status. Evaluation will prioritize Technical Acceptability and Past Performance as significantly more important than Price, though Price becomes increasingly relevant when proposals are closely matched in technical merit. All submissions must include completed representations and certifications per FAR 52.212-3 and comply fully with FAR 52.212-1 and 52.212-4. Proposals must be submitted electronically via email to the designated NASA contacts no later than 1:00 PM CST on August 24, 2026, with questions due by July 29, 2026. The Government assumes no responsibility for electronic submission failures, and late submissions will be rejected per FAR provisions. The place of performance is Houston, Texas, and the Ombudsman clause is applicable for dispute resolution.

NASA Johnson Space Center

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