Bioanalytical Assay Development and Quantification
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The contract requires the development and performance of liquid chromatography-tandem mass spectrometry assays to quantify plasma concentrations of three small-molecule inhibitors and their metabolite 1-MNA in mouse plasma samples. The work involves establishing validated methods for accurate and precise measurement of these compounds, ensuring reliability for preclinical pharmacokinetic studies. The assays must be capable of detecting low concentrations with appropriate sensitivity, specificity, and reproducibility across the expected concentration range in biological matrices. This subcontract is issued under the NAICS code 541380, indicating a focus on scientific and technical consulting services, and is associated with the National Institutes of Health under the Department of Health and Human Services. The solicitation was posted on August 7, 2026, with a response deadline of August 24, 2026. The place of performance and specific location details are not provided, and no set-aside provisions are specified. The work is intended to support biomedical research activities, likely aimed at evaluating drug metabolism and exposure profiles in mouse models.
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