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Biomarkers of Cognitive Decline and Dementias of Aging in Individuals within the Autism Spectrum

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Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institute on Aging, under the Department of Health and Human Services, is forecasting a Notice of Funding Opportunity to support observational studies on age-related neurodegeneration in individuals with Autism Spectrum Disorders. The primary objective is to characterize the manifestation of Alzheimer's disease and related dementias across the ASD spectrum to develop tailored precision-medicine strategies. Proposed research should focus on deep phenotyping of aging individuals and the validation or discovery of biomarkers associated with cognitive decline. This initiative will utilize the U01 activity code and specifically encourages collaborative partnerships between experts in autism and those specializing in aging and dementia. While applications are not currently being solicited, this forecast is intended to provide potential applicants time to establish necessary collaborations between neurodevelopmental and age-related cognitive decline research centers.

General Info

NIA invites U01 applications for ASD aging studies focusing on neurodegeneration and dementia biomarkers.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

0

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health
Contacts1 person available
OfficeUSA
Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health
Office AddressUSA
Contacts
Alessandra Rovescalli Ph.D. National Institute on Aging (NIA
contact@example.gov
+1 (555) 000-0000

Full Description

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The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to invite applications to conduct observational studies in individuals living with Autism Spectrum Disorders (ASD) along the lifespan. The overarching goal is to determine the occurrence of age-related neurodegeneration across the heterogeneities of the ASD spectrum, characterize the physiopathology and manifestation of Alzheimer's disease (AD) and AD-related dementias (ADRD) in ASD, and, ultimately, develop precision-medicine strategies tailored to this understudied population. It is expected that proposed studies pursue deep phenotyping of aging individuals across the ASD spectrum, along with the characterization/validation of existing biomarkers of age-related cognitive decline and/or dementia in this population, and/or the discovery of novel ones. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO intends to utilize the U01 activity code. This NOFO encourages collaborations between investigators with expertise in autism and those with expertise in aging and dementia, fostering interactions between established centers for neurodevelopmental research and centers studying age-related cognitive decline. 

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