Cardiothoracic Surgical Trials Network (CTSN) Linked Clinical Research Centers
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The National Heart, Lung, and Blood Institute (NHLBI) under the Department of Health and Human Services is issuing solicitation RFA-HL-27-002 to expand an international cardiac surgery research platform. This initiative aims to integrate interventional cardiology and peri-operative care with new research areas including dissemination and implementation science, circadian medicine, and mechanistic science. The platform is designed to foster collaborations between academia, small businesses, professional societies, foundations, and international entities to advance innovative technologies, devices, pharmaceutical products, and bioengineered solutions to improve health outcomes for adults with cardiovascular disease and neurologic complications. Additionally, the platform will serve as a hub for training future clinical trialists and implementation researchers. A specific component of this effort is the solicitation of a single-source U01 cooperative agreement to support the Cardiothoracic Surgical Trials Network (CTSN) Data Coordinating Center. This center will encompass a Data Management and Analytics Center and a Clinical Coordination Center, tasked with managing randomized clinical trials, data collection, statistical analysis, and regulatory support. The program emphasizes a public investment model to accelerate the integration of new medical strategies and techniques through a coordinated network of linked clinical research centers.
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Full Description
The NHLBI intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on expanding the scope of an international cardiac surgery research platform, which already includes interventional cardiology, and peri-operative care of cardiac patients. Other areas of HLBS research will be incorporated, including dissemination and implementation science, circadian medicine, and mechanistic science efforts. The predominantly public investment that created this platform will continue to utilize additional sources of funding that allow broad stakeholders, including academia, small businesses, professional societies, foundations and international research entities to collaborate and advance newer techniques, technologies, devices, and innovative pharmaceutical and bioengineered products, as well as strategies to accelerate their reach and integration, to improve the health of adults with cardiovascular disease and associated neurologic complications. Further, this enhanced platform will be used to train the next generation of clinical trialists and implementation researchers centrally.
Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into this area are encouraged to begin to consider applying for this NOFO.
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