Cellular Senescence Network (SenNet): SenNet Data Coordination, Integration and Organizational Center (U24 or UM1)
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The National Institutes of Health, including the National Institute on Aging and National Cancer Institute, is forecasting a Notice of Funding Opportunity for Stage 2 of the Cellular Senescence Network (SenNet) Program. This initiative focuses on understanding the biological consequences of senescent cell heterogeneity and identifying tissue-specific markers in human biospecimens to support the development of senotherapeutic strategies. A central component of this effort is the SenNet Data Coordination, Integration and Organizational Center (DCIOC), which will manage consortium activities and create Atlases of Senescence by integrating spatial biomarker distribution with functional data across various tissues and age-associated diseases. The program will utilize the U24 or UM1 activity codes and is seeking investigators with expertise in cellular senescence, innovative technology development, and computational tools for targeting senescent cells in vivo. While applications are not currently being accepted, this forecast is intended to give potential applicants time to establish collaborations. The opportunity is managed by the Department of Health and Human Services and is categorized under NAICS code 541715.
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The NIH Common Fund, National Institute on Aging, National Cancer Institute and additional NIH Institutes and Centers (ICs) intend to publish a Notice of Funding Opportunity (NOFO) to solicit applications for Stage 2 of the Cellular Senescence Network (SenNet) Program, which seeks to understand the biological consequences of senescent cell heterogeneity in health and disease, identify and characterize tissue-specific senescence markers in human biospecimens to facilitate the development of senotherapeutic strategies that improve health outcomes. The program’s SenNet Data Coordination, Integration and Organizational Center (DCIOC) will integrate tissue mapping efforts with Stage 2 data to generate Atlases of Senescence incorporating the spatial distribution of senescence biomarkers with biological and functional data across tissues in health, lifespan and age-associated diseases. The DCIOC will also serve as the organizational hub for SenNet in managing consortium and outreach activities. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 or UM1 activity code. Investigators with expertise and insights into the cellular senescence impact on human health, the development of innovative technologies and computational tools to identify and characterize senescent cells and inform novel approaches for the strategic targeting of senescent cells in vivo are encouraged to apply in response to these new NOFOs.
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