This Government Contract opportunity from Department Of Defense was posted on July 20, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Co-Translational Protein Editing Systems

Closed

Federal

Submission Closed07/31/2026, 12:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541715

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FA2385 USAF Afmc Afrl Pzl Afrl Rskd

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U.S. Army Contracting Command – Sierra Army Depot (ACC-SIAD) Organic Industrial Base (OIB) Modernization Commercial Solutions Opening (CSO)

Solicitation # W912GY-25-S-C001

The U.S. Army Contracting Command – Sierra Army Depot (ACC-SIAD) has issued solicitation W912GY-25-S-C001 as a Commercial Solutions Opening (CSO) to modernize its Organic Industrial Base (OIB). The primary objective is to enhance the Speed of Battle through investments in producibility and advanced manufacturing, specifically targeting agile and flexible facilities, connected digital enterprises, digital twins, automation, and cybersecurity. This streamlined acquisition process, authorized under DFARS Subpart 212.70, allows the Department of Defense to competitively procure innovative commercial items, technologies, and services from both traditional and non-traditional defense contractors. The solicitation remains open until June 30, 2030, and utilizes a multi-phased evaluation process consisting of solution briefs, presentations or pitches, and commercial solution proposals. The program focuses on several continuously open Areas of Interest (AoI), including automation and robotics, logistics modernization, airfield maintenance, energy and environmental management, public-private partnerships, and advanced packaging manufacturing. Specific requirements may also be issued for equipment, such as the Roll Off Truck AoI. Awards will be made as fixed-price contracts, including fixed-price incentive fee, following FAR Part 12 Commercial Item Procedures. Eligible applicants must possess a Unique Entity ID, maintain active registration in the System for Award Management, and be registered in the PIEE invoicing system. Evaluation is based on technical adequacy, eligibility, and fair and reasonable pricing, with a particular focus on intellectual property and data rights assertions during the pitch phase.

W6QK Siad Contr Office

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Advanced Driver Assistance Systems (ADAS), on road networks at the Fish and Wildlife Service’s (FWS) National Wildlife Refuges (NWR)

Solicitation # 6913G626Q300038

The Department of Transportation's Volpe National Transportation Systems Center is soliciting a firm-fixed-price purchase order to conduct research on Advanced Driver Assistance Systems (ADAS) performance at U.S. Fish and Wildlife Service National Wildlife Refuges. The primary objective is to evaluate how SAE Level 1-2 automation performs in non-typical environments, specifically focusing on wildlife detection, visitor interaction, and unpaved road conditions. Field testing will occur at one or two selected sites, including the Desert, Neal Smith, and Parker River National Wildlife Refuges. The contractor is responsible for providing all vehicles, data-logging instruments, fuel, power, and software, as no government-furnished property will be provided. The period of performance extends from the date of award through August 15, 2028, though offerors may propose a timeline of up to 24 months. Key deliverables include a Data Management Plan, high-fidelity field data, operational logs, a final technical report, and an executive briefing. Award decisions will be based on the most advantageous offer, considering technical capability, past performance, and price, with technical and performance factors weighted approximately equal to cost. Proposals must include a safety component for risk mitigation and a procurement and instrumentation plan. Invoicing must be processed electronically through the iSupplier DELPHI system using login.gov authentication.

6913G6 Volpe National Transportation System Cntr

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Synthetic Training Environment (STE) Virtual Software (VSW)

Solicitation # STE-VSW-26-0006

The Army Contracting Command-Aberdeen Proving Grounds (ACC-APG) Orlando Division, on behalf of the Capability Program Executive Simulation, Training, Test & Threat, is issuing a Call for Solutions (CFS) under the Army Open Solicitation (AOS) for the Synthetic Training Environment (STE) Virtual Software (VSW). This initiative aims to modernize immersive virtual training by addressing gaps in the Reconfigurable Virtual Collective Trainer software baseline. The government is utilizing a Government-as-Integrator model divided into five capability lots, focusing on a platform and application architecture. The primary objectives are to deliver a doctrinal gate to live fire, a true combined arms environment, full mission command concurrency, and an open system architecture with published SDKs and APIs to facilitate rapid integration of future capabilities. The total combined value of all awarded lots is approximately 250 million dollars. The acquisition process follows a phased selection approach based on technical merit, schedule achievability, and relevant experience. Evaluation factors prioritize the technical schedule, specifically the speed to Initial Operating Capability, followed by the technical approach and recent performance within the last three years. The project is eligible for Other Transaction Agreements (OTA) per 10 U.S.C. 4022. A strict organizational conflict of interest firewall is enforced for Lot 5, prohibiting those vendors from participating in Lots 1, 2, or 4. Key milestones include a solution deadline of September 28, 2026, followed by down-select notifications on October 2, 2026, and anticipated awards for Lots 1 through 5 by November 13, 2026. Performance is managed on a sprint-to-sprint basis, requiring signed Certificates of Completion to proceed to subsequent funding milestones.

POSTED

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Advanced Research Projects Agency for Health (ARPA-H) Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) Program

Solicitation # 7599226SN106

The Advanced Research Projects Agency for Health (ARPA-H) is soliciting proposals from small business concerns (SBCs) for its Fiscal Year 2026 Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. The program aims to stimulate technological innovation and increase private sector commercialization of federal research and development. Eligible participants must be for-profit businesses located in the United States with no more than 500 employees. The solicitation focuses on seven high-impact research topics: the development of an annual fertility test, versatile bioadhesives, a universal platform for living adaptive toxin-removal, non-surgical therapies for endometriosis, rapid diagnostics for multi-system autoimmune disease, a virtual human brain for neurosurgical robotics, and the ARPA-H Lineage topic for advancing previously funded technologies. The submission process is structured in two stages. Stage 1 requires a Solution Summary, SBA proof of registration, and various certifications. Stage 2 involves a more detailed submission including a technical presentation, a Task Description Document, a cost proposal, and a key personnel worksheet. Awards are based on technical merit, novelty, team experience, and the path to health outcomes, subject to funding availability and security risk assessments. The program utilizes fixed payment milestones and provides additional Technical and Business Assistance (TABA) funding of up to 6,500 dollars for Phase I and 50,000 dollars for Phase II projects. All proposers must maintain an active SAM.gov registration and adhere to strict marking requirements for proprietary technical data.

Advanced Research Projects Agency For Health (arpa-H)

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Connected Vehicle Data Subscription

Solicitation # 693JJ326Q000030

The Federal Highway Administration is seeking a comprehensive Connected Vehicle Dataset subscription to obtain anonymized, high-frequency vehicle telemetry from vehicles manufactured after 2019. This data must be delivered at intervals of one to three seconds across the continental United States to support safety analytics and operational performance evaluations at intersections and interchanges. The contract consists of a nine-month base subscription period with an option for one additional nine-month extension. The government intends to solicit this requirement as a single source from Compass IoT Pty Ltd, citing their proprietary platform and specialized data pipelines as the only means to achieve the required interval fidelity and geographical penetration. While this is not a request for competitive proposals, interested parties may submit capability statements to the primary point of contact, Amy Morrissette, to demonstrate their technical ability to meet these specific parameters.

693JJ3 Acquisition And Grants Mgt

POSTED

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Missile Defense Agency - Advanced Capability Concepts

Solicitation # HQ0860-25-S-C001

The Missile Defense Agency (MDA) has issued solicitation HQ0860-25-S-C001 for its Advanced Capability Concepts program, an ongoing opportunity open from May 9, 2025, to May 8, 2030. The agency seeks innovative concepts, scientific breakthroughs, and prototype demonstrations to enhance the robustness and effectiveness of all Missile Defense System elements. Key focus areas include kinetic and hypersonic defense, command and control battle management, integrated non-kinetic and electronic warfare, and disruptive technologies such as AI/ML, resilient networking, and advanced sensors. This is a two-step process where industry is invited to submit white papers on a rolling basis, which are then evaluated for potential negotiation and award. Submissions must follow strict formatting guidelines, including a 10-page limit for the combined executive summary and program description, and must include a Rough Order of Magnitude cost estimate and a program summary quad chart. Awards may be structured as either FAR-based procurement contracts or Other Transaction (OT) agreements, depending on the offeror's recommendation and eligibility. Evaluation is based on a trade-off process prioritizing technical achievement, research capabilities, and program management. Offerors must maintain active SAM.gov registration, disclose any organizational conflicts of interest, and comply with NIST SP 800-171 for safeguarding controlled unclassified information. Performance is centered in Huntsville, Alabama, though the agency emphasizes rapid development and compressed timelines for the transition of breakthroughs into acquisition programs.

Missile Defense Agency (mda)

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Disruptioneering Program Announcement

Solicitation # DARPA-PA-25-07

The DARPA Defense Sciences Office (DSO) Disruptioneering Program, under solicitation DARPA-PA-25-07, seeks to identify and leverage nascent scientific advances for national security through high-risk, high-payoff research. The program utilizes Disruption Opportunities (DOs) to rapidly investigate new concepts, enabling the initiation of unclassified efforts in less than 120 calendar days from inception. Awards are issued as Other Transaction (OT) agreements for prototype projects under 10 U.S.C. § 4022, focusing on proofs of concept, pilots, and the demonstration of technical or operational utility. Proposals are not submitted to the general program announcement but must be responded to via individual DOs. Selection is based on a weighted evaluation of overall scientific and technical merit, potential contribution to the DARPA mission, and price reasonableness, which serves as a mandatory pass/fail gate. Proposals are evaluated on their own individual merit rather than against each other. Awardees must comply with strict cybersecurity standards, including NIST SP 800-171 for safeguarding Controlled Unclassified Information (CUI) and reporting cyber incidents. Administrative requirements include registration in the Wide Area Workflow (WAWF) for electronic invoicing and the provision of SAM Unique Entity Identifiers. Payments are milestone-driven and contingent upon verification by the DARPA Agreements Officer's Representative.

Defense Advanced Research Projects Agcy

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Solicitation # DARPA-PS-26-127

The Defense Advanced Research Projects Agency (DARPA) Multi X Office is soliciting innovative proposals under solicitation DARPA-PS-26-127, titled Perrseus, to develop microscale ultra-high-vacuum systems (uUHV). The program aims to enable compact cold-atom devices and environmentally-decoupled ultra-high Q microelectromechanical (MEMS) and photonics devices, specifically targeting manufacturable vacuum packages with pressures below 10^-10 mbar. The effort is structured as an Other Transaction for Prototype Agreement under 10 U.S.C. 4022, with an estimated period of performance of 42 months starting January 15, 2027. This includes a three-month Phase 0 for security set-up followed by technical development phases. Proposals are evaluated based on overall scientific and technical merit, potential contribution to the DARPA mission, and budget, price, and schedule. Key requirements include CMMC Level 2 self-assessment and strict adherence to Controlled Unclassified Information (CUI) handling guidelines. The program emphasizes low Size, Weight, and Power (SWaP) and high-volume manufacturability. Awardees must deliver ten functional prototypes and undergo in-person government validation of vacuum metrics. The submission process requires a technical and management volume, a detailed price volume, and an oral presentation, with a final proposal deadline of September 23, 2026.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Light Forces Enhancement

Solicitation # WS5642957262

Public Services and Procurement Canada is seeking industry feedback for the Light Forces Enhancement project on behalf of the Department of National Defence and the Canadian Armed Forces. The objective is to acquire new light tactical personnel and cargo carrying capabilities to transport soldiers and equipment across complex terrain that is currently only accessible on foot. This solution aims to reduce the individual combat burden on soldiers by carrying additional supplies and increasing the overall speed, range, and duration of operations. The required capabilities must be powerful and lightweight, suitable for both domestic and expeditionary deployments, including high threat environments. This solicitation, identified by number WS5642957262, was posted on September 11, 2026, with a response deadline of October 16, 2026. The project falls under NAICS code 541715 and is managed by the Department of Public Works and Government Services.

Department of Public Works and Government Services

POSTED

DEADLINE

R3PEATS Multi-Team Triangulation: Collaborative Cross-Method Approaches to Scientific Discovery (RM1)The R3PEATS Multi-Team Triangulation initiative, managed by the National Institutes of Health under the Department of Health and Human Services, focuses on collaborative cross-method approaches to scientific discovery. This program supports coordinated teams investigating central biomedical research questions using complementary populations, model systems, or methods. A primary objective is to enhance scientific excellence by identifying signal robustness and biological variability while integrating replication directly into the research design. This effort is part of the broader NIH Common Fund program dedicated to Rigor, Replicability, and Reproducibility to Promote Excellence, Accuracy, and Translation in Science. The opportunity is currently listed as a forecast with a posted date of September 11, 2026, and interested parties can contact the R3PEATS Program for further information.

National Institutes Of Health

POSTED

1 day ago

DEADLINE

N/A

AI Contract Overview

The contract seeks the development of innovative systems capable of modifying proteins during translation, enabling real-time, dynamic alterations to nascent polypeptide chains as they are synthesized. This initiative aims to establish technologies that can introduce functional changes—such as post-translational modifications, chemical tagging, or structural rearrangements—directly at the ribosome, fundamentally expanding the capabilities of synthetic biology and molecular engineering. The effort requires integration of biochemistry, molecular machinery, and precise control mechanisms to ensure site-specific and temporally coordinated edits without disrupting the natural folding or function of the emerging protein. The work is classified under NAICS code 541715 for research and development in biotechnology and is issued as a subcontract by the Defense Advanced Research Projects Agency under the Department of Defense. Proposals must be submitted by July 31, 2026, with the solicitation posted on July 20, 2026. While the exact location of performance is unspecified, the technology must be scalable, robust, and suitable for potential defense-related applications involving adaptive proteins, molecular sensors, or responsive therapeutics. Successful solutions will represent a breakthrough in controlling protein function at the time of synthesis, opening new avenues for precision bioengineering in high-stakes operational environments.