This Government Contract opportunity from Department Of Defense was posted on July 20, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Protein Splicing & Ligation Technology Development

Closed

Federal

Submission Closed07/31/2026, 12:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541715

New

Federal

Advanced Capability Research & Development

Missile Defense Agency (mda)

POSTED

DEADLINE

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Industrial Security Technologies, Strategy, and Research (ISTS/ISSR)

Defense Ci And Security Agency

POSTED

1 day ago

DEADLINE

in 10 days

AI Contract Overview

The contract focuses on the research and development of innovative enzymatic or synthetic techniques designed to achieve precise splicing and ligation of endogenous proteins, enabling functional editing at the protein level without altering the underlying genetic code. This effort aims to advance biological control by directly modifying protein structure and function in living systems, bypassing the risks and permanence of gene editing. The work must yield scalable, reliable methods that can be applied across diverse cellular environments and is intended to support high-impact applications in defense and biomedical innovation. The solicitation, titled Protein Splicing & Ligation Technology Development, is issued under NAICS code 541715 as a subcontract opportunity by the Defense Advanced Research Projects Agency within the Department of Defense. Proposals are due by July 31, 2026, with the opportunity posted on July 20, 2026. The project requires advanced expertise in biochemistry, molecular engineering, and protein chemistry, with an emphasis on precision, efficiency, and biological compatibility. The place of performance and point of contact details are unspecified, but the work is expected to align with the agency’s broader goals in next-generation bioengineering and resilient biological systems.

General Info

Develop enzymatic techniques for precise protein splicing and ligation without genetic modification for defense and biomedical use.

Agency

Department Of Defense → Defense Advanced Research Projects AgcyView Agency

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

Set-Aside

NONE

Documents

This scope was carved out of DARPA-SN-26-102.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

Protein ENGineering (PENG) Proposer Day

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Timeline

PhaseClosed

PostedJul 20

subcontract

Response DeadlineJul 31

Deadline has passed

Submission Closed

07/31/2026, 12:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

ContactsNo contacts available

OfficeN/A

Organization / Agency

Department Of Defense → Defense Advanced Research Projects Agcy

View Agency Profile

Office AddressN/A

ContactsNo contact information available

Full Description

Research and development of novel enzymatic or synthetic methods for precise splicing and ligation of endogenous proteins to enable functional editing without gene-level modifications.