DoW Bone Marrow Failure, Investigator-Initiated Research Award
Contract Overview
Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.
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The Defense Health Agency Contracting Activity is soliciting applications for the FY26 Bone Marrow Failure Research Program Investigator-Initiated Research Award. This funding opportunity supports research aimed at advancing bone marrow failure studies and patient care, including translational and clinical research, preclinical models, and IND-enabling efforts. While clinical research is permitted, the award mechanism specifically excludes the support of clinical trials. The program is managed by the Congressionally Directed Medical Research Programs with a total FY26 appropriation of 7.50 million dollars. Approximately one award will be granted with a total cost cap of 1.25 million dollars over a maximum period of three years. The application process involves a two-tier review consisting of a peer review for technical merit and a programmatic review for relevance to FY26 priorities. Applicants must submit a pre-application by August 5, 2026, followed by a full application due November 4, 2026. The funding mechanism allows for a partnering Principal Investigator, though both the initiating and partnering PIs must submit separate application packages. Eligibility requires active registration in SAM.gov, eBRAP.org, and Grants.gov. Awardees are required to provide annual and final technical progress reports in accordance with Research Performance Progress Report standards and must comply with federal animal and human subjects protection requirements.
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Full Description
Summary: Supports studies that further develop mature ideas, expand upon key discoveries, and have the potential to make significant advances in bone marrow (BMF) failure research and/or patient care. Investigator-Initiated Research Award (IIRA) applications may involve translational and clinical research including studies in preclinical models, research with human data and/or anatomical substances, and research with human subjects, as well as correlative studies associated with a clinical trial(s); however, this award mechanism does not support clinical trials. IIRA applications may also support Investigational New Drug (IND)-enabling efforts such as lead compound characterization, and assessments of formulation and stability, absorption, distribution, metabolism and excretion, dose/response and toxicology.
Distinctive Features:
This funding mechanism allows for a partnering Principal Investigator (PI). Only the initiating PI will submit a pre-application, but both PIs will need to submit full applications. The partnering PI application is an abbreviated package specific to their distinct portion of the research project. Be advised, all associated applications for a research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn.
This award mechanism requires preliminary data relevant to the proposed project. Applications can support clinical research studies; however, this mechanism does not allow clinical trials.
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