Evaluation of Drug Efficacy in a Rodent Model of Neuropathic Pain

There is an unmet medical need for safer, less addictive, and more effective solutions for chronic pain management. Current methods involving the prescription of opioids to patients with chronic pain has led to an unsustainable and deadly epidemic of addiction. Alternative methods of treating pain are therefore required to mitigate opioid substance abuse and addiction. The object of this project is to establish the efficacy of the nanoparticle formulation by replicating previous research investigations that compared the nanoparticle formulation to a free drug formulation. The scope of this project is for the contractor to execute the neuropathic pain model in adult rodents, treat animals with the compounds, and evaluate drug efficacy at different doses by measuring evoked and spontaneous pain. Specifically, the contractor shall perform a Mouse SNS (Sural Nerve Spared) model of neuropathic pain with use of von Frey Hairs (vFH) for assessment of mechanical allodynia. See attached Request for Quotations, Statement of Work, and other attachments for complete requirement details.