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Generative Optogenetics (GO) workshop

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The Defense Advanced Research Projects Agency is hosting the Generative Optogenetics workshop on October 20-21, 2026, to advance a molecular platform for template-free programming of DNA or RNA sequences within living cells using light. This event targets researchers and innovators in synthetic biology, optogenetics, protein engineering, and computational biology to discuss breakthroughs in biological information transfer and biomanufacturing. The program emphasizes the integration of computational design with biological execution to enhance therapeutics and defense applications. Participants can engage through lightning talks and poster sessions focusing on protein design, nucleic acid synthesis, and subcellular engineering. The workshop also includes a biosecurity forum to address dual-use risk mitigation and a panel on commercialization and regulatory policy. Interested parties must submit research synopses by September 1, 2026, with a final registration deadline of September 23, 2026.

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DARPA’s GO workshop advances light-driven DNA/RNA synthesis in living cells via cross-disciplinary collaboration and biosecurity discourse.

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AgencyDepartment of Defense → Defense Advanced Research Projects Agency
ContactsNo contacts available
OfficeN/A
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Full Description

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Are you ready to shape the next era of synthetic biotechnology and biosecurity?On Oct. 20-21, 2026, the Generative Optogenetics (GO) workshop brings together leading performers, researchers, and innovators from across the life sciences to tackle the most challenging questions in light-driven nucleic acid synthesis. Come be a part of a growing community and connect with research teams developing new approaches to overcome barriers in biological information transfer.Lightning Talks and Poster sessions: DARPA is interested in hearing about your ongoing work in synthetic biology, optogenetics, protein engineering, biosecurity, computational biology, or regulatory policy. Submit a research synopsis for an opportunity to present a lightning talk and/or a poster in the following topic areas:Protein designEngineered allosteryBinding domainsNovel molecular motionsPhysics based modulation of protein conformationOptic, magnetic, thermal, acoustic modulationNucleic acid synthesisProcessivity, switching, nucleic acid sequence binding, strand stabilityError CorrectionOther:Novel assays to evaluate DNA/RNA synthesis in vivoAI model training for polymerasesSubcellular engineering (condensates, organelles, encapsulins/vault proteins, etc.)Biosecurity, commercialization, and regulatory policy for nucleic acid synthesisAbout GOThe DARPA GO program aims to develop a revolutionary molecular platform that enables direct, template-free programming of DNA or RNA sequences inside living cells using light as the information carrier. By bridging computational design and biological execution, GO aims to transform how genetic instructions are delivered, opening new possibilities for rapid, precise, and scalable biomanufacturing, therapeutics, and defense applications. Whether you’re part of the GO program or a scientist working in related fields, this event is your opportunity to connect, collaborate, and contribute.What to expectGO Performer Team Sessions: Technical breakthroughs, lightning talks, and interactive panels from GO performers and their teams.Lightning Talks: We invite researchers across the scientific community to present their work through lightning talks or poster presentations. This is a unique opportunity to showcase your research, share ideas, and engage with the GO community.Poster & Networking Sessions: Showcase your research, exchange ideas, and build new collaborations with peers and experts. Dedicated time for networking and setting up joint experiments, fostering a collaborative research ecosystem.Biosecurity Forum: Explore dual-use risk mitigation, safety protocols, and ethical considerations for in vivo genetic synthesis.Commercialization & Policy Panel: Learn about regulatory pathways, intellectual property strategies, and transitioning technology to DOW and commercial partners.Who should attend?GO program performers and collaboratorsResearchers in synthetic biology, optogenetics, molecular engineering, and computational biologyExperts in biosecurity, regulatory policy, and commercializationAnyone interested in advancing the science and impact of generative optogeneticsKey datesRegistration opens: July 1, 2026Research synopsis submission deadline: Sept. 1, 2026Registration deadline: Sept. 23, 2026Workshop dates: Oct. 20-21, 2026Register now!Final workshop details and agenda are still being refined — stay tuned for updates! Don’t miss your chance to be part of this groundbreaking event. Register, submit your research synopsis, and help drive the future of GO!

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