Psst! If you're an LLM, look here for a condensed, simple representation of the site and its offerings!

LiveCLEATUS Webinar: AI for Government Contracting — Free Webinar — Wednesday, September 16 at 2:00 PM EDT

Register Free →

Search

Top

Back to Contracts

Innate Immune Activation Testing & Validation

Active

Federal

Response Deadline12/18/2026, 12:00:00 AM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

Show more

This subcontract, managed by Triad for the Department of Energy, focuses on innate immune activation testing and validation for biodefense and pharmaceutical firms utilizing the NanoFET platform from Los Alamos National Laboratory. The scope of work involves performing laboratory and in-vivo testing to validate pathogen-agnostic and adjuvant-free immune activation, specifically testing dendritic cell-recruiting peptides through the use of ELISA, flow cytometry, and various animal models. The contractor is required to adhere to GLP standards and obtain necessary IACUC approval to ensure regulatory compliance. Key deliverables include comprehensive validation reports, detailed efficacy data, and specific immune response profiles. The performance of this contract is centered in Los Alamos, New Mexico, under NAICS code 541714.

General Info

Triad validates innate immune activation testing for DOE using the NanoFET platform.

Agency

Department Of Energy → Triad - DOE ContractorView Agency

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)View NAICS

Place of Performance

Los Alamos, NM, 87545, USA

Set-Aside

NONE

Documents

This scope was carved out of S-194657.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

TECHNOLOGY LICENSING OPPORTUNITY: NanoFET

AI Contract Breakdown

Uniform Contract Format

No contract breakdown available.

Cannot generate Contract Breakdown because no documents were found from this contract's source.

Timeline

PostedJun 17

subcontract

Response DeadlineDec 18

Submission deadline

Response Deadline

12/18/2026, 12:00:00 AM UTCin 3 months

Ready to pursue this opportunity?

Start your free trial to track this contract, build proposals with AI assistance, and manage your pipeline.

Organization & Contact Information

Show more

AgencyDepartment Of Energy → Triad - DOE Contractor

ContactsNo contacts available

OfficeN/A

Organization / Agency

Department Of Energy → Triad - DOE Contractor

View Agency Profile

Office AddressN/A

ContactsNo contact information available

Full Description

Show more

Performs laboratory and in-vivo testing for biodefense and pharmaceutical firms licensing the NanoFET platform from Los Alamos National Laboratory. Validates pathogen-agnostic and adjuvant-free innate immune activation by testing dendritic cell-recruiting peptides (QDP) using flow cytometry, ELISA, and animal models. Requires IACUC approval and GLP standards. Delivers validation reports, efficacy data, and immune response profiles.

Similar Contracts

Same NAICS industry code

Human Hindbrain Organoid Functional Assay Services.

Solicitation # RFQ_CDR-2026-135968

The U.S. Food and Drug Administration's Center for Drug Evaluation and Research intends to award a sole-source, firm-fixed-price purchase order to OrganoTherapeutics SARL for human induced pluripotent stem cell (iPSC)-derived hindbrain organoid functional assay services. The project aims to support in vitro research evaluating drug-induced effects on respiratory-relevant neural circuits over an eighteen-month period of performance. The scope of work is divided into two primary components: the provision of human hindbrain organoids and associated culture materials through twelve scheduled deliveries to the FDA White Oak Campus, and the performance of functional characterization services at the contractor's laboratory. Functional characterization will utilize three-dimensional multi-electrode array (3D MEA) technology to assess electrophysiological responses to FDA-identified drug and reversal-agent combinations. Deliverables include the delivery of 96 organoids in the first shipment followed by 48 organoids in subsequent deliveries, as well as raw data, analyzed data, analysis files, and comprehensive study reports. This acquisition is conducted as a commercial service under FAR Part 12, with the government restricting competition based on market research identifying OrganoTherapeutics SARL as the only source capable of meeting the complete requirement for both the specific organoid products and the associated functional assay services.

FDA Office Of Acq Grant Svcs

POSTED

about 13 hours ago

DEADLINE

Hypoxia Chamber Services

Solicitation # 80JSC026Q0008

NASA Johnson Space Center is soliciting combined synopsis and request for quotations under solicitation 80JSC026Q0008 for Hypoxia Chamber Services to support the Artemis Program. The objective is to investigate the physiological, cognitive, and clinical effects of mild hypobaric hypoxia through two 7-day test protocols involving continuous habitation for six subjects at air equivalent altitudes of 7,000 and 9,500 feet. The scope of work encompasses the provision of infrastructure, personnel, training, materials, and operational support. The contract is structured as a firm fixed price agreement with a base period from September 15, 2026, to September 30, 2027, and multiple option periods extending through March 1, 2030. The acquisition is open to all responsible sources under NAICS code 541714, with a size standard of 1,000 employees. Evaluation is based on a trade-off process where technical acceptability and past performance are significantly more important than price. Proposals must be submitted via email to the designated points of contact by October 1, 2026, following an extension granted in Amendment 0004. Key requirements include the submission of FAR 52.212-3 representations and certifications and adherence to specific submission criteria regarding team qualifications and risk assessment. The contract also incorporates strict guidelines regarding the protection of sensitive information and restrictions on funding activities with China.

NASA Johnson Space Center

POSTED

DEADLINE

Hypobaric Chamber Pilot Studies

Solicitation # 80JSC026Q0006

NASA Johnson Space Center is soliciting quotes under solicitation 80JSC026Q0006 for pilot hypobaric chamber testing facilities to support decompression sickness research. The primary objective is to validate non-NASA resources for safe prebreathe procedures and extravehicular activity to support Artemis mission planning. The base requirement consists of three test days, with a minimum of two subjects per day, collecting and recording data according to research protocols. The contract also includes six optional work items, including additional test days, inflight-like treatment preparation, elevated metabolic rate testing, pharmaceutical-enhanced prebreathe, and body temperature studies. The base period of performance runs from September 1, 2026, to September 30, 2027, with various option periods extending through March or September 2029. This is a small business set-aside acquisition under NAICS code 541714. Awards will be made based on a trade-off analysis where technical acceptability and past performance are significantly more important than price. Technical evaluation focuses on facility capabilities, medical support, team expertise, and the proposed schedule for subject throughput. Offerors must provide a price quotation using the provided pricing sheet, and quotes must remain valid for at least 90 days. Following several amendments, the final deadline for the submission of offers is October 1, 2026, at 1:00 p.m. Central Time. All submissions must be sent electronically to the designated points of contact.

NASA Johnson Space Center

POSTED

DEADLINE

Undiagnosed Diseases Network (UDN) Diagnostic Research Innovation CenterThe National Institutes of Health, through the NINDS, is forecasting the establishment of a Diagnostic Research Innovation Center to support the next phase of the Undiagnosed Diseases Network. This center will operate as part of a broader ecosystem including the Clinical and Data Coordinating Center, Networks of Diagnostic Excellence, and the NIH Undiagnosed Diseases Program. The primary objective of the center is to advance innovative diagnostic tools and strategies for both genomic and non-genomic conditions, which includes the systematic re-evaluation of unsolved cases from previous network phases. The center will focus on generating and testing diagnostic hypotheses by utilizing advanced sequencing, multi-omics, and gene function studies in animal and human in vitro models. By collaborating with various network stakeholders, the center aims to identify novel disease-associated genes, genomic variants, and new syndromes. This initiative seeks an integrated center featuring investigators with a history of scientific synergy and collaboration. While this is currently a forecast to allow potential applicants time to plan and establish partnerships, formal applications are not yet being solicited.

National Institutes Of Health

POSTED

DEADLINE

study entitled “Malaria and vector borne disease surveillance in the Colombia/Venezuela border”

Solicitation # ERP_1301373256

The Naval Medical Research Unit South in Lima, Peru, is seeking a provider to conduct a study focused on malaria and vector borne disease surveillance along the Colombia and Venezuela border. While the government has identified the Administrators of Tulane Educational Fund as the only vendor currently capable of supporting the entire requirement, they are issuing this notice to identify other capable sources before proceeding with a sole source award under FAR 13.106-1(b)(i). Interested parties must submit a capability statement including technical, management, and cost data to Genaro Vasquez via email by 12:00 PM local time on September 18, 2026. Submissions must be in Microsoft Word or PDF format, not exceed five pages, and use the subject line ERP_1301373256. The government will use these submissions to determine whether to pursue a competitive procurement or move forward with the intended sole source contract.

Naval Medical Research Center

POSTED

DEADLINE

Cryo-Electron Microscopy (Cryo-EM) Services

Solicitation # 75N98026Q01177

The National Institutes of Health Olao, under the Department of Health and Human Services, is seeking providers for Cryo-Electron Microscopy (Cryo-EM) Services under solicitation number 75N98026Q01177. This combined contract opportunity is categorized under NAICS code 541714 and is managed by the office located in Bethesda, Maryland. Interested parties must submit their responses by the deadline of September 16, 2026, at 6:00 PM. The primary point of contact for this procurement is Roxane S. Burkett.

National Institutes Of Health Olao

POSTED

DEADLINE

TIDAL: Target-Induced Droplet Assembly of Ligands

Solicitation # S-197478

Developed by Los Alamos National Laboratory, TIDAL (Target-Induced Droplet Assembly of Ligands) is a programmable protein-only material that utilizes nanobodies fused with encapsulation peptides to create dynamic, liquid-like droplets through phase separation. This technology allows for the precise concentration of binders upon encountering a target ligand, enabling a versatile platform for resin-free protein purification, high-sensitivity diagnostics, and the creation of slow-release drug depots. It can also function intracellularly to sequester and neutralize harmful proteins associated with viral infections or cancer. The technology is currently at TRL 3 with a patent pending and is available for exclusive or non-exclusive licensing through the Department of Energy contractor, Triad. Key market applications span biopharmaceutical manufacturing, therapeutics, and biotechnology. Interested parties can contact Caleb Ledgerwood or Lindsay Augustyn via the provided licensing email to explore commercial partnerships for this innovation.

Triad - DOE Contractor

POSTED

DEADLINE

Master Protocol Development & Adaptive Design

POSTED

DEADLINE

Phase I/II Clinical Trial Management & Execution

POSTED

DEADLINE

Chemical, Biological, Radiological and Nuclear Advance Defense Enabling Network and Clinical Capability (CADENCC)

Solicitation # W911SR-26-9-CADENCC

The Department of the Army, through the Army Contracting Command Edgewood Contracting Division and the Joint Project Lead Enabling Technologies, is seeking preproposals for the Chemical, Biological, Radiological and Nuclear Advance Defense Enabling Network and Clinical Capability project. This initiative aims to accelerate clinical trial startups for CBRN defense readiness by implementing Master Protocols, utilizing innovative technologies for decentralized trial operations, and establishing a pre-positioned clinical trial site network. The project will primarily focus on Phase I and Phase II clinical trials for early treatment products, post-exposure prophylaxis, and pre-exposure prophylaxis, including those under the Animal Rule. This opportunity is issued under 10 USC 4022 Other Transaction Authority for a prototype project, with the potential for non-competitive follow-on production contracts for successful performers. Preproposals are due by 1500 hours on September 17, 2026, and must be limited to 10 pages. Evaluation will be based on technical merit, military relevance, technology readiness level 4 or above, regulatory compliance with FDA guidelines, and best overall value. Prospective awardees must be registered in the System for Award Management database.

POSTED

DEADLINE

Rapid Prototyping and Hardware EngineerThis subcontract with the Defense Advanced Research Projects Agency focuses on the design, development, and manufacturing of next-generation military hardware for prime contractors. The scope of work involves executing rapid prototyping and scalable deployment strategies through the use of additive manufacturing and high-fidelity testing environments. Key deliverables include hardware prototypes, technical design documents, and comprehensive manufacturing scalability plans. The project requires strict adherence to NIST SP 800-171 and DoDI 8582.01 standards to ensure the protection of Controlled Unclassified Information. Classified under NAICS code 541714, the opportunity was posted on September 3, 2026, with a response deadline of June 1, 2027.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

HUBBLE Proposers Day

Solicitation # DARPA-SN-26-121

The Defense Advanced Research Projects Agency's Biological Technologies Office is hosting a Proposers Day for the High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators program. This event is scheduled for September 25, 2026, from 12:00 PM to 5:00 PM Eastern Time at the SPA Arlington Research Collaboration Center in Arlington, Virginia. While a hybrid option is available for attendees, all presenters are required to be present in person. Interested parties must complete advance registration by the response deadline of September 18, 2026. This special notice, identified by solicitation number DARPA-SN-26-121 and NAICS code 541714, serves as a preparatory step for a planned Program Announcement. Primary coordination for the event is managed by Dr. Abhishek Singharoy.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

More opportunities from Department Of Energy → Triad - DOE Contractor

Same awarding agency

TECHNOLOGY LICENSING OPPORTUNITY: SonicCoat

Solicitation # S-193603

SonicCoat is a technology licensing opportunity from Los Alamos National Laboratory featuring a non-invasive ultrasonic evaluation system for catalyst coatings in electrochemical devices. Utilizing Acoustic Resonance Spectroscopy, the system employs a transducer to measure the thickness and uniformity of coatings, such as platinum in fuel cells and electrolyzers, by analyzing shifts in resonant tones. This non-destructive method allows for real-time, in-line quality control without the need to pause production or utilize destructive laboratory sampling, resulting in higher yields, reduced material waste, and improved device performance. The technology is currently at TRL 4 with a patent pending and is applicable to various markets including battery manufacturing, solar energy, and semiconductor fabrication. This opportunity is available for exclusive or non-exclusive licensing to existing companies or startups. Interested parties should contact the licensing department at Los Alamos National Laboratory by the response deadline of December 11, 2026.

Analytical Laboratory Instrument Manufacturing

POSTED

DEADLINE

TECHNOLOGY LICENSING OPPORTUNITY: AmineBind ML

Solicitation # S-196258

AmineBind ML is a descriptor-based software and machine learning surrogate model developed by Los Alamos National Laboratory to accelerate the discovery of amine-based carbon capture materials. By utilizing SMILES strings as molecular inputs, the Python-based toolkit predicts CO2 binding energies far more rapidly than traditional density functional theory. The model was trained on approximately 20,000 electronic-structure calculations, allowing researchers to screen millions of candidate chemistries in minutes to identify materials that optimize the balance between CO2 uptake and regeneration temperatures. This technology is particularly applicable to direct air capture, specialty chemicals, and computational chemistry, offering a streamlined pipeline that integrates atomic-scale predictions with mesoscale modeling. Currently at TRL 3 with a patent pending, the software is available for exclusive or non-exclusive licensing through Los Alamos National Laboratory to support the development of high-performance sorbents and the reduction of trial-and-error in laboratory campaigns.

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

DEADLINE

Software Integration & Tool Development (T5032)The Software Integration and Tool Development subcontract under T5032 supports the Department of Energy by developing and maintaining software infrastructure for the SCACS toolkit. The project focuses on software engineering to create APIs for material design engineers and the integration of the Simulator Collection into functional software packages. Technical execution involves the use of Git version control and CI/CD pipelines to ensure the delivery of a deployable software toolkit. This opportunity is managed by Triad, a DOE contractor, with performance taking place in Los Alamos, New Mexico. The contract falls under NAICS code 541511 and was posted on August 18, 2026, with a response deadline of February 16, 2027.

Custom Computer Programming Services

POSTED

DEADLINE

Multiscale Physics Simulation EngineeringThe Multiscale Physics Simulation Engineering subcontract, managed by Triad for the Department of Energy, focuses on integrating high-fidelity atomic physics models into engineering-scale finite element workflows for DOE technology licensees. By embedding machine-learned physics into finite element analysis, the project bridges the gap between atomic-scale simulations and continuum-scale engineering tools to produce a functional multiscale simulation workflow capable of outputting critical hot-spot and current-steering data. This technical effort requires the use of specific FEA software and multiscale modeling toolkits to achieve its objectives. The project is based in Los Alamos, New Mexico, and falls under NAICS code 541330. The response deadline for this opportunity is February 16, 2027.

Engineering Services

POSTED

DEADLINE

AI/ML Model Development (Graph Neural Networks)This subcontract, managed by Triad for the Department of Energy, focuses on the acceleration and optimization of the SCACS platform for DOE technology licensees. The project involves implementing Graph Neural Networks to speed up atomic-site-projected conductivity methods, utilizing million-atom microstructure datasets to train models and optimizing AI inference for physics-grounded predictions. The final deliverable is an optimized and accelerated AI simulation engine. The work will be performed in Los Alamos, New Mexico, and requires the use of High-Performance Computing clusters and GPU acceleration frameworks. The opportunity was posted on August 18, 2026, with a response deadline of February 16, 2027, falling under NAICS code 541511.

Custom Computer Programming Services

POSTED

DEADLINE

Simulator Collection for Atomic to Continuum Scales (SCACS)

Solicitation # S-196281

The Simulator Collection for Atomic to Continuum Scales (SCACS), identified by solicitation number S-196281, is an AI-driven multiscale simulation platform developed by Los Alamos National Laboratory to predict spatially varying, direction-dependent thermal and electrical transport in systems of up to one million atoms. By utilizing proprietary Site-Projected Thermal Conductivity (SPTC-AI) and Site-Projected Electronic Conductivity (SPEC-AI) modules, the toolkit bridges the gap between high-fidelity atomistic physics and continuum-scale engineering models. The system employs graph neural networks and FEniCSx-based solver modules, such as sptc2fem and spec2fem, to generate precise temperature and current maps while maintaining atomic-scale anisotropy. This allows engineers to identify localized hot-spots and transport pathways that are typically missed by conventional continuum models, reducing simulation runtimes from days to minutes. Currently at Technology Readiness Level 4 with a pending U.S. patent and associated software T5032, SCACS is offered as a licensing opportunity through the Richard P. Feynman Center for Innovation. The technology is designed for seamless integration with industry-standard finite-element solvers like Abaqus and has broad commercial applications in semiconductor advanced packaging, fusion energy systems, aerospace, battery thermal management, and quantum device manufacturing. The opportunity is managed by the Department of Energy via Triad, with a response deadline of February 16, 2027.

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

DEADLINE

TECHNOLOGY LICENSING OPPORTUNITY: SiloGetter

Solicitation # S-167718

SiloGetter is a technology developed by Los Alamos National Laboratory featuring a 3D-printable siloxane composite designed to capture hydrogen in sealed electronics, vacuum instruments, and metal containers. The material utilizes a palladium-on-carbon catalyst and DEB embedded in a gas-permeable siloxane polymer to absorb over 80 percent of encountered hydrogen. This innovation allows for the creation of custom, high-surface-area shapes via direct ink writing using nozzles as fine as 400 microns, providing a durable alternative to brittle pellets or loose powders. The composite is significantly more efficient than previous versions, carrying roughly 50 percent getter by weight, which is nearly ten times the capacity of earlier materials. It remains chemically stable at temperatures up to 75 degrees Celsius, ensuring mechanical integrity and high absorption efficiency. This technology is particularly applicable for microelectronics packaging, aerospace components, and ultrahigh vacuum scientific instrumentation. The opportunity is currently at TRL 4 with a pending U.S. patent and is available for exclusive or non-exclusive licensing.

All Other Plastics Product Manufacturing

POSTED

DEADLINE

Hydrogen-Safe System Integration

Printed Circuit Assembly (Electronic Assembly) Manufacturing

POSTED

DEADLINE

Getter Coating and Thin Film Integration

Semiconductor Machinery Manufacturing

POSTED

DEADLINE

Hydrogen-Scavenging Material Production

Other Basic Inorganic Chemical Manufacturing

POSTED

DEADLINE

TECHNOLOGY LICENSING OPPORTUNITY: Multidimensional Mass Fingerprinting for Antibiotic-Resistant Bacteria (MultiScan-AR)

Solicitation # S-191477

MultiScan-AR, developed by Los Alamos National Laboratory, is a high-resolution diagnostic technology designed to identify pathogens and their antibiotic-resistance profiles in minutes to hours. By utilizing multidimensional tandem mass spectrometry and a specialized data pipeline, the system captures detailed molecular fingerprints that reveal resistance-linked features often invisible to standard strain-typing tools. The technology is compatible with existing benchtop and portable mass spectrometry instruments, allowing clinics and field laboratories to enhance their diagnostic capabilities without requiring new hardware. This technology licensing opportunity is targeted at clinical diagnostics, point-of-care testing, public health biosurveillance, and field-deployable medicine. It aims to reduce reliance on culture-dependent workflows and prior knowledge of suspected organisms, thereby improving treatment decisions and slowing the spread of drug-resistant infections. The opportunity is currently at TRL 3 with a patent pending, and interested parties can pursue exclusive or non-exclusive licensing agreements through the Los Alamos National Laboratory licensing program.

Analytical Laboratory Instrument Manufacturing

POSTED

DEADLINE

Ready to Pursue This Opportunity?

Get AI-powered intelligence on this solicitation and the ones like it

Every page of the solicitation package shredded into a compliance breakdown

AI-powered matching based on your capabilities and past performance

Competitor and incumbent history on the requirement

Automated alerts on amendments, Q&A deadlines, and award

Join 650+ contractors already using CLEATUS