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Medicinal Chemistry Support for Therapeutic Development: Synthesis of HERV-K Protease Inhibitors

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75N98026Q00906Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institutes of Health is seeking commercial offerings for the synthesis of HERV-K protease inhibitors as part of medicinal chemistry support for therapeutic development, under solicitation number 75N98026Q00906. This is a competitive, firm-fixed-price acquisition conducted under FAR Subpart 12.6 as a streamlined solicitation for commercial items, with a projected value not exceeding $350,000. The government intends to award the contract to the offeror providing the best value based on technical capability, price, past performance, and delivery schedule. The work involves the design and synthesis of inhibitors targeting HERV-K protease, and responses must include full pricing details, delivery terms, F.O.B. point, product identifiers, and a clear timeline for completion after award. All offerors must be active in SAM.gov and provide their Unique Entity Identifier, Taxpayer Identification Number, and business size certification. The requirement is not set aside for small businesses, and the associated NAICS code is 541380. Proposals must be submitted electronically by August 10, 2026, at 9:00 AM Eastern Time to James Law at James.Law@nih.gov and must include the completed FAR 52.212-3 representations and certifications. The contract will be formed automatically upon written notice of award if submitted within the specified timeframe. Additional evaluation criteria may consider warranty, lifecycle costs, maintenance availability, and environmental efficiency. The place of performance is Bethesda, Maryland, and all terms and conditions are governed by FAR 52.212-4 and 52.212-5, incorporating applicable statutory and executive order requirements. Offerors are expected to demonstrate proven ability in medicinal chemistry, particularly in organic synthesis and protease inhibitor development, with the capability to deliver high-quality compounds on schedule.

General Info

NIH seeks commercial synthesis of HERV-K protease inhibitors under $350,000 firm-fixed-price contract with technical and pricing evaluation.

Agency

Department Of Health And Human Services → National Institutes Of Health OlaoView Agency

NAICS

541380 - Testing Laboratories and ServicesView NAICS

Place of Performance

Bethesda, MD, 20892, USA

Set-Aside

NONE

Documents

(0)

No documents available

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Timeline

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao
Contacts1 person available
OfficeBETHESDA, MD, 20892, USA
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health Olao
View Agency Profile
Office AddressBETHESDA, MD, 20892, USA
Contacts
LAW JAMES B
contact@example.gov

Full Description

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COMBINED SYNOPSIS / SOLICITATION


Title: Medicinal Chemistry Support for Therapeutic Development: Synthesis of HERV-K Protease Inhibitors


This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested, and a separate written solicitation will not be issued.


The solicitation number is 75N98026Q00906. This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition.


This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold of $350,000.00.


The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a Firm-Fixed-Price to the responsible offeror whose proposal represents the best value to the Government.


The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2026-01 March 13, 2026.


The associated NAICS code is 541380, and the small business size standard is N/A.


This requirement is NOT A SET-ASIDE for small businesses.


Description of Requirement:


Medicinal Chemistry


The provision at FAR 52.212-1, Instructions to Offerors—Commercial Items, applies to this acquisition. Add any agency-specific instructions as required.


The provision at FAR 52.212-2, Evaluation—Commercial Items, applies to this acquisition.


The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation represents the best value to the Government, price and other factors considered.


Evaluation Factors:


  • Technical capability
  • Price
  • Past performance
  • Delivery schedule

A written notice of award or acceptance of an offer, issued within the time specified in the offer, shall result in a binding contract without further action by either party. The Government reserves the right to accept any offer before the expiration date.


Offerors shall include a completed copy of FAR 52.212-3, Offeror Representations and Certifications—Commercial Items, with their offer.


FAR 52.212-4, Contract Terms and Conditions—Commercial Items, applies to this acquisition.


FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders—Commercial Items, applies to this acquisition.


Submission Requirements:
Responses must include sufficient information to demonstrate the offeror’s capability to provide the required product or service. Quotes shall include, at a minimum:


  • Unit and total price
  • Shipping and handling costs
  • Delivery timeframe after award
  • Delivery terms
  • F.O.B. point (destination)
  • Product or catalog numbers (if applicable)
  • Product/service description

Additional evaluation considerations may include past performance, warranty, lifecycle cost, maintenance availability, and environmental or energy efficiency.


Responses must include the Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification. All offerors must be actively registered in the System for Award Management (SAM) at www.sam.gov.


All responses must be received by August 10, 2026 at 9:00 AM and must reference solicitation number 75N98026Q00906. Responses may be submitted electronically to James.Law@nih.gov.


Point of Contact:
James Law


James.law@nih.gov

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Software Support & Data Analysis ConsultingThe contract seeks ongoing software support and expert consulting focused on flow cytometry data analysis, panel design, and interpretation specifically for cell therapy applications. The work involves providing specialized technical expertise to ensure accurate and efficient processing of complex cellular data, with an emphasis on practical implementation in therapeutic contexts. Consultants are expected to deliver sustained support that enhances data reliability, improves analytical workflows, and aligns with the latest scientific standards in immunology and cell therapy research. This subcontract is issued under NAICS code 541690 for other scientific and technical consulting services and is associated with the National Institutes of Health through the Department of Health and Human Services. Performance is required to be conducted in Bethesda, Maryland, with a response deadline of August 3, 2026. The solicitation was posted on July 29, 2026, and the nature of the engagement implies the need for deep domain knowledge in both flow cytometry methodologies and cell therapy development pipelines, requiring the contractor to deliver timely, high-quality advisory services that directly support ongoing biomedical research initiatives.
Other Scientific and Technical Consulting Services

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NAICS: 339113
New
Federal
Specialized Accessories SupplyThe contract titled Specialized Accessories Supply seeks the provision of Miltenyi-compatible accessories including a carrying case, sample rack, and tube holder to support seamless integration with an existing main system. These components are essential for ensuring proper handling, storage, and operational efficiency of laboratory equipment within the target workflow. The solicitation is open for responses until August 3, 2026, and is classified as a subcontract under NAICS code 339113, indicating it pertains to medical equipment and supplies manufacturing. Performance is required at Bethesda, Maryland, with the National Institutes of Health under the Department of Health and Human Services as the contracting entity. All submissions must be prepared to meet exact technical specifications for compatibility and durability to ensure full functionality with the Miltenyi platform.
Surgical Appliance and Supplies Manufacturing

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3 days ago

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NAICS: 611430
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Federal
On-Site Technical Training DeliveryThe contract requires the delivery of on-site technical training to National Institutes of Health staff at the Bethesda location with a zip code of 20892, focusing specifically on the operation of the MACSQuant Analyzer 10. Training content must cover software use, data acquisition procedures, and troubleshooting techniques to ensure NIH personnel can effectively and independently manage the instrument. The opportunity is classified as a subcontract under NAICS code 611430, indicating it is related to other schools and instruction services, and is issued by the Department of Health and Human Services through its agency, the National Institutes of Health Olao. The solicitation was posted on July 29, 2026, with a strict response deadline of August 3, 2026, at 9:00 p.m. Eastern Time, requiring timely submission of proposals. All training activities must be conducted in person at the designated federal facility in Bethesda.
Professional and Management Development Training

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3 days ago

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NAICS: 811212
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Federal
Flow Cytometry System Installation & Validation ServicesThe contract entails the on-site installation qualification and operational qualification of the MACSQuant Analyzer 10 system within a regulated laboratory setting, ensuring full compliance with industry and regulatory standards. The services must be performed at the designated location in Bethesda, Maryland, with all activities tailored to meet the rigorous validation requirements of a controlled environment. The work involves verifying that the instrument is correctly installed, functions as intended, and consistently produces reliable results under specified operating conditions, critical for maintaining data integrity and regulatory compliance in scientific research. This subcontract is issued under the NAICS code 811212 and is managed by the National Institutes of Health under the Department of Health and Human Services. The solicitation was posted on July 29, 2026, with a strict response deadline of August 3, 2026, requiring timely submission of proposals. The performance site is clearly defined, and all work must be executed in accordance with applicable quality systems and regulatory guidelines. Although no specific set-aside details or point of contact are provided, the scope is narrowly focused on validation services for diagnostic instrumentation in a high-compliance laboratory environment.
Computer and Office Machine Repair and Maintenance

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NAICS: 334516
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Federal
Notice of Intent: MACSQuant Analyzer 10 flow cytometer
Solicitation # 75N98026Q00901
The National Institutes of Health Office of Laboratory Animal Welfare is issuing a notice of intent to procure a MACSQuant Analyzer 10 flow cytometer under solicitation number 75N98026Q00901. This action is designated as a presolicitation, indicating an upcoming procurement process with no set-aside provisions, meaning the contract is open to all eligible vendors regardless of business size or status. The NAICS code 334516 identifies the procurement as related to laboratory equipment manufacturing, aligning the expected product with precision biomedical instrumentation. The notice was posted on July 29, 2026, with responses due by August 3, 2026, at 9:00 PM Eastern Time, providing a five-day window for interested parties to prepare submissions. The equipment will be delivered and installed at the agency's location in Bethesda, Maryland, with a ZIP code of 20892, ensuring alignment with federal research facility requirements. Primary point of contact for inquiries is David Shen, reachable via email at david.shen@nih.gov, and additional information can be found on the SAM.gov website through the provided UI link.
Analytical Laboratory Instrument Manufacturing

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