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NATIONAL CANCER INSTITUTE (NCI) SMALL BUSINESS INNOVATION RESEARCH (SBIR) INNOVATIVE CONCEPT PHASE I AWARD PROGRAM

Closed

75N98026R00109Federal

Submission Closed09/21/2026, 09:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 54171

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Federal

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Solicitation # RFX-2026-10008

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Llc - DOE Contractor Alliance For Energy Innovation

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Chain Reaction Innovations - Energy Technology Innovation

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Argonne National Labor - DOE Contractor

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Announcement for Partnership Proposals: Atmospheric Exploration Observatory

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Research Opportunities for International Space Station (ISS) Utilization

Solicitation # 80JSC026ISSNRA

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DEADLINE

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Solicitation # HQ0034259WHSCSO

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Washington Headquarters Services

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DEADLINE

Request for Information (RFI) for Advancing Critical and Emerging Microelectronics Technologies

Solicitation # 26_04

Issued by Sandia National Laboratories under the Department of Energy, solicitation 26_04 is a Request for Information aimed at advancing critical and emerging microelectronics technologies to secure U.S. global leadership and strengthen the domestic semiconductor manufacturing supply chain. The initiative focuses on four primary priority areas: advanced semiconductor research and prototyping, including power electronics and 3D packaging; the application of artificial intelligence for microelectronics R&D, such as AI-driven autonomous agents and edge computing; the development of quantum technologies, including scalable quantum computing and sensing; and the commercialization of federally funded scientific innovations. Interested parties must submit a response in PDF or Word format, not exceeding five pages, by September 30, 2029. Submissions will be evaluated based on the relevance and completeness of the information, the clarity of the response, the respondent's technical understanding of the project goals, and their overall experience and qualifications. Primary points of contact for this effort are Ken Dean and Lauren Kemme.

POSTED

DEADLINE

LPS Qubit Collaboratory (LQC)

Solicitation # W911NF21S0009

The LPS Qubit Collaboratory (LQC), a partnership between the U.S. Army Research Office and the NSA's Laboratory for Physical Sciences, is soliciting research proposals to advance disruptive fundamental research in quantum information science and technology. The program focuses on qubit development for quantum computing and sensing, aiming to solve long-term challenges in qubit device physics, such as material selection, gate fidelity, and the operation of superconducting qubits. The LQC operates as a center without walls, fostering collaborative partnerships between academia, industry, FFRDCs, and government laboratories to build a future quantum workforce and create pathways for technology transition. Proposals are accepted in three categories: Incubator opportunities for single investigators or small groups to develop concepts; Collaboratory proposals for multi-sector teams to pursue proof-of-concept experiments over one to three years; and QuaCR Research Fellowships for U.S. citizen graduate and postdoctoral researchers. Eligible applicants include domestic and foreign institutions of higher education, nonprofits, and for-profit businesses. Awards are evaluated based on scientific and technical merit, potential contribution to quantum computing feasibility, investigator qualifications, and cost reasonableness. The current response deadline for submissions is April 30, 2027.

POSTED

DEADLINE

AFRL/RX Functional Materials Open BAA

Solicitation # FA8650-22-S-5002

The Air Force Research Laboratory Materials and Manufacturing Directorate is soliciting white papers and full proposals under Broad Agency Announcement FA8650-22-S-5002 to advance functional materials technologies. The program focuses on the full maturity spectrum from scientific discovery through transition into components and systems, with specific interests in Photonic Materials, including Optical Materials and Processes and Hardened Materials and Processing. The objective is to exploit innovative materials from academia, defense, and commercial sectors to enhance warfighting capabilities, specifically improving size, weight, and power characteristics. Total program funding is approximately 500 million dollars, with individual contract awards capped at 75 million dollars. The solicitation utilizes a two-step process requiring an initial white paper followed by a technical and cost proposal for selected offerors. Awards are anticipated to be Cost Plus Fixed Fee contracts with periods of performance ranging from 12 to 72 months. Evaluation is based on peer or scientific review, agency importance, and funding availability, with technical merit as the primary priority. Due to the sensitive nature of the research, strict security requirements are in place, including a Security Risk Review to mitigate foreign influence, adherence to the AFRL Wright Research Site Security Requirements, and potential Secret level safeguarding as specified in DD Form 254. Deliverables include scientific and technical reports, proof-of-concepts, and prototype hardware or software.

FA8650 USAF Afmc Afrl Pzl Afrl/pzl

POSTED

8 months ago

DEADLINE

in about 2 years

AI Contract Overview

The National Cancer Institute (NCI) is soliciting research proposals from small business concerns for its Phase I Small Business Innovation Research (SBIR) Innovative Concept Award Program under solicitation 75N98026R00109. This high-risk, high-reward program focuses on developing transformative technologies for pediatric and rare cancers, specifically targeting those with a five-year survival rate of less than 50 percent. The scope is divided into two primary topics: the development of therapeutic or preventative technologies and the creation of devices, diagnostic technologies, or digital health tools. The program aims to demonstrate proof-of-concept and feasibility for game-changing R&D, and while preliminary data is not required, proposals must be based on a sound scientific premise and identify a clear development path toward a marketable product. The deadline for proposal submission is 5:00pm on September 21, 2026, via the electronic Contract Proposal Submission (eCPS) portal. Awards provide a base R&D budget of up to 300,000 dollars for up to 12 months, with an additional 6,500 dollars available for Technical and Business Assistance (TABA). Proposals are evaluated through a triage process and a peer review panel based on potential for innovation and impact (50 percent), scientific rationale and approach (20 percent), commercialization potential (20 percent), and personnel and resources (10 percent). Key requirements include registration in the System for Award Management (SAM) and the SBA Company Registry, as well as the submission of a signed SF30 Amendment. Notably, non-exempt human subjects research is not supported, and the requirement for a Data Management Sharing Plan was removed via Amendment 0002.

General Info

NCI SBIR Phase I funding for transformative pediatric and rare cancer research technologies.

Agency

Department Of Health And Human Services → NIH Nci

NAICS

54171

Place of Performance

MD, USA

Set-Aside

SBA

Documents

Amendment 0001 to RFP 75N98026R00109 for NCI SBIR Innovative Concept Phase I Award Program

amendment

High

Amendment 0002 to RFP 75N98026R00109 for NCI SBIR Innovative Concept Phase I Award Program

amendment

High

Amendment 0003 to Solicitation 75N98026R00109 SBIR Phase I Innovative Concept Award

amendment

High

NCI SBIR FY25 Phase I Concept Award Technical Proposal Form

technical-proposal-form

High

NCI SBIR Innovative Concept Phase I Solicitation 75N98026R00109

rfp

High

AI Contract Breakdown

Uniform Contract Format

Timeline

3 updates

PhaseClosed

PostedJul 10

Solicitation

Notice updatedJul 10

Notice details unchanged. Attachments may have changed.

Notice updatedJul 24

The notice description changed.

Notice updatedAug 10

The notice description changed.

Response DeadlineSep 21

Deadline has passed

Submission Closed

09/21/2026, 09:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → NIH Nci

Contacts1 person available

OfficeBethesda, MD, 20892, USA

Organization / AgencyDepartment Of Health And Human Services → NIH Nci

Office AddressBethesda, MD, 20892, USA

Contacts

Kathleen Sears

contact@example.gov

Full Description

THIS EDIT IS TO POST AMENDMENT #3. AMENDMENT #3 IS TO provide key questions and answers received in writing by email.

Offerors are required to submit a signed copy of the SF30 Amendment (page 1 only) with their Business Proposal submission.

The deadline for receipt of proposals remains unchanged at 5:00pm, September 21, 2026.

All other terms and conditions of the solicitation remain unchanged.

PLEASE SEE ATTACHED AMENDMENT #3 PDF.

_______________________________________________________________________________________________________

THIS EDIT IS TO POST AMENDMENT #2. AMENDMENT #2 IS TO remove the Data Management Sharing Plan requirement and all references under Sections 5.9 Management and Sharing of Research Data, 6.1 Evaluation Process, Evaluation of Data Management and Sharing Plan, 8.5 Technical Proposal Content (I) Scientific Data Sharing.

The deadline for receipt of proposals remains unchanged at 5:00pm, September 21, 2026.

All other terms and conditions of the solicitation remain unchanged.

PLEASE SEE ATTACHED AMENDMENT #2 PDF.

________________________________________________________________________________________________________

ORIGINAL SOLICITATION DESCRIPTION:

The National Cancer Institute (NCI) invites small business concerns to submit research proposals under this Phase I Small Business Innovation Research (SBIR) contract solicitation. Firms with the capability to conduct research and development (R&D) in the health-related topic areas referred to below and described more fully in Section 11.0, and to commercialize the results of that R&D, are encouraged to participate.

The topic areas that are being sought under this solicitation are:

Topic 1: Development of therapeutic or preventative technologies for treatment or prevention of Pediatric Cancers and/or Rare Cancers.

For this solicitation rare cancers with a 5-year survival rate of less than 50% are encouraged.

Topic 2: Development of devices, diagnostic technologies, or digital health tools for treatment, detection, and diagnosis of Pediatric Cancers and/or Rare Cancers.

For this solicitation, rare cancers with a 5-year survival rate of less than 50% are encouraged.

The National Cancer Institute is soliciting proposals from small business concerns who are looking for an opportunity to perform a few key activities to demonstrate proof-of-concept and feasibility of untested but potentially transformative, game-changing research and development (R&D) technologies to help cancer patients, providers and caregivers, in conjunction with Small Business Innovation Research (SBIR) program objectives. The NCI has established a high-risk, high-reward SBIR “Innovative Concept Award” Program for this purpose.

Preliminary data is not required; however, the ideas should have sound scientific premise either based on the offeror’s own research or literature evidence. Proposals will need to identify an anticipated product that will be developed and clearly lay out the anticipated development path. Proposals will need to clearly identify the clinical problem and cancer type(s) that the proposal will focus on with adequate justification. In addition, the offerors should propose experiments to obtain initial de-risking and proof-of-concept data.

Note: Non-exempt Human subjects research will not be supported under this solicitation.

Phase I Concept Award contractors will be informed of the opportunity to apply for Phase II. Only one Phase II award may result from a single Phase I SBIR contract. The United States Department of Health and Human Services (HHS) is not obligated to make any awards under this solicitation. All awards are subject to the availability of funds. HHS is not responsible for any monies expended by the offeror before award of any contract.